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Nature：模拟肿瘤生长，以及肿瘤内部异质性的3D计算机模型问世

2015-08-28 MedSci MedSci原创

3D肿瘤异质性
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近期，来自哈佛大学、爱丁堡大学和约翰•霍普金斯大学的科学家们合作完成了首个实体瘤3D计算机模型。该模型不仅刻画了一种致命肿瘤的形状，还展现了它的生长、突变以及演变的过程。这个模型有助于人们对肿瘤内部异质性的理解，以及肿瘤的生长转移机制，以及治疗效果的评价。 a, b, A spherical lesion in the absence of dispersal (M 

近期，来自哈佛大学、爱丁堡大学和约翰•霍普金斯大学的科学家们合作完成了首个实体瘤3D计算机模型。该模型不仅刻画了一种致命肿瘤的形状，还展现了它的生长、突变以及演变的过程。这个模型有助于人们对肿瘤内部异质性的理解，以及肿瘤的生长转移机制，以及治疗效果的评价。

Short-range dispersal affects size, shape and growth rate of tumours.

a, b, A spherical lesion in the absence of dispersal (M = 0) (a) and a conglomerate of lesions (b), each initiated by a cell that has migrated from a previous lesion, for low but non-zero migration (M = 10−6). 

 






科学家称，该模型将帮助他们理解肿瘤是如何产生抗药性的。此前，大多数科学家仅通过平面模型研究肿瘤的演变过程，无法了解到实体瘤的空间特征。而该新3D模型则解决了这一难题。该模型目前最重大的成果在于发现了癌细胞的局部移动能力。在使用新药物之后，大部分癌细胞被杀死，但可能有少量具有抗药能力的细胞存活下来。它们进行快速复制，从而导致癌症复发。这些细胞通过移动，与同类细胞共享一套突变机制，从而加速扩散这种抗药能力的基因。这是癌细胞快速产生抗药性的原因之一。科学家也进一步猜测，这种局部移动性有可能是导致癌细胞转移，最终使病人死亡的原因。该研究已在《自然》杂志上发表

原始出处：
Waclaw B, Bozic I, Pittman ME, Hruban RH, Vogelstein B, Nowak MA.A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity. Nature. 2015 Aug 26. doi: 10.1038/nature14971

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  1. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150904/IMG55E8DB68F05883098.jpg, createdBy=e00a1631985, createdName=fengzhigu, createdTime=Fri Sep 04 00:25:00 CST 2015, time=2015-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36231, encodeId=de5a3623106, content=强大, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51a41609947, createdName=jiaoaoxiaoxu, createdTime=Sun Aug 30 11:26:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335880, encodeId=b214133588064, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Aug 30 07:43:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36226, encodeId=60ec3622688, content=研究很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd59104596, createdName=ghamdi2, createdTime=Sun Aug 30 07:42:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36211, encodeId=df7f3621192, content=学习了，。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2016-04-30 jiekemin

    #计算机模型#

    0

  2. 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attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Aug 30 07:43:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36226, encodeId=60ec3622688, content=研究很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd59104596, createdName=ghamdi2, createdTime=Sun Aug 30 07:42:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36211, encodeId=df7f3621192, content=学习了，。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Aug 29 23:46:00 CST 2015, time=2015-08-29, status=1, ipAttribution=)]
    2016-01-26 doctording1

    这篇文章有一定深度

    0

  3. 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    2016-03-01 liye789132251

    #Nat#

    0

  4. 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createdBy=def632217870, createdName=bioon14, createdTime=Fri Oct 23 04:43:00 CST 2015, time=2015-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38982, encodeId=2b843898244, content=不知道这个系统的运行速度怎么样，是否能用于抗肿瘤药物的筛选, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Fri Oct 16 10:13:00 CST 2015, time=2015-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36379, encodeId=542e363e957, content=很厉害啊！, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150904/IMG55E8DB68F05883098.jpg, createdBy=e00a1631985, createdName=fengzhigu, createdTime=Fri Sep 04 00:25:00 CST 2015, time=2015-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36231, encodeId=de5a3623106, content=强大, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51a41609947, createdName=jiaoaoxiaoxu, createdTime=Sun Aug 30 11:26:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335880, encodeId=b214133588064, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Aug 30 07:43:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36226, encodeId=60ec3622688, content=研究很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd59104596, createdName=ghamdi2, createdTime=Sun Aug 30 07:42:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36211, encodeId=df7f3621192, content=学习了，。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Aug 29 23:46:00 CST 2015, time=2015-08-29, status=1, ipAttribution=)]
    2015-10-23 bioon14

    #计算机#

    0

  5. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150904/IMG55E8DB68F05883098.jpg, createdBy=e00a1631985, createdName=fengzhigu, createdTime=Fri Sep 04 00:25:00 CST 2015, time=2015-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36231, encodeId=de5a3623106, content=强大, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51a41609947, createdName=jiaoaoxiaoxu, createdTime=Sun Aug 30 11:26:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335880, encodeId=b214133588064, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Aug 30 07:43:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36226, encodeId=60ec3622688, content=研究很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd59104596, createdName=ghamdi2, createdTime=Sun Aug 30 07:42:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36211, encodeId=df7f3621192, content=学习了，。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Aug 29 23:46:00 CST 2015, time=2015-08-29, status=1, ipAttribution=)]
    2015-10-16 lixh1719

    不知道这个系统的运行速度怎么样，是否能用于抗肿瘤药物的筛选

    0

  6. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150904/IMG55E8DB68F05883098.jpg, createdBy=e00a1631985, createdName=fengzhigu, createdTime=Fri Sep 04 00:25:00 CST 2015, time=2015-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36231, encodeId=de5a3623106, content=强大, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51a41609947, createdName=jiaoaoxiaoxu, createdTime=Sun Aug 30 11:26:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335880, encodeId=b214133588064, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Aug 30 07:43:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36226, encodeId=60ec3622688, content=研究很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd59104596, createdName=ghamdi2, createdTime=Sun Aug 30 07:42:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36211, encodeId=df7f3621192, content=学习了，。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Aug 29 23:46:00 CST 2015, time=2015-08-29, status=1, ipAttribution=)]
    2015-09-04 fengzhigu

    很厉害啊！

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Aug 30 07:43:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36226, encodeId=60ec3622688, content=研究很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd59104596, createdName=ghamdi2, createdTime=Sun Aug 30 07:42:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36211, encodeId=df7f3621192, content=学习了，。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Aug 29 23:46:00 CST 2015, time=2015-08-29, status=1, ipAttribution=)]
    2015-08-30 jiaoaoxiaoxu

    强大

    0

  8. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150904/IMG55E8DB68F05883098.jpg, createdBy=e00a1631985, createdName=fengzhigu, createdTime=Fri Sep 04 00:25:00 CST 2015, time=2015-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36231, encodeId=de5a3623106, content=强大, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51a41609947, createdName=jiaoaoxiaoxu, createdTime=Sun Aug 30 11:26:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335880, encodeId=b214133588064, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Aug 30 07:43:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36226, encodeId=60ec3622688, content=研究很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd59104596, createdName=ghamdi2, createdTime=Sun Aug 30 07:42:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36211, encodeId=df7f3621192, content=学习了，。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Aug 29 23:46:00 CST 2015, time=2015-08-29, status=1, ipAttribution=)]
    2015-08-30 ms9833124466084992

    #3D#

    0

  9. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150904/IMG55E8DB68F05883098.jpg, createdBy=e00a1631985, createdName=fengzhigu, createdTime=Fri Sep 04 00:25:00 CST 2015, time=2015-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36231, encodeId=de5a3623106, content=强大, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51a41609947, createdName=jiaoaoxiaoxu, createdTime=Sun Aug 30 11:26:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335880, encodeId=b214133588064, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Aug 30 07:43:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36226, encodeId=60ec3622688, content=研究很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd59104596, createdName=ghamdi2, createdTime=Sun Aug 30 07:42:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36211, encodeId=df7f3621192, content=学习了，。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Aug 29 23:46:00 CST 2015, time=2015-08-29, status=1, ipAttribution=)]
    2015-08-30 ghamdi2

    研究很厉害

    0

  10. 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authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Aug 29 23:46:00 CST 2015, time=2015-08-29, status=1, ipAttribution=)]
    2015-08-29 lecoo

    学习了，。

    0

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