Obesity:儿童肥胖与母亲产前接触全氟烃基类物质有关

2015-11-24 MedSci MedSci原创

一项前瞻性队列研究显示如果母亲在产前暴露于较高浓度PFOA(perfluorooctanoic acid,全氟辛酸铵酸),儿童在儿童早期的总体肥胖率会增大,BMIz评分(BMIz)增加的更快。这项研究在 Obesity在线发表。

一项前瞻性队列研究显示如果母亲在产前暴露于较高浓度PFOA(perfluorooctanoic acid,全氟辛酸铵酸),儿童在早期的总体肥胖率会增大,BMIz评分(BMIz)增加的更快。这项研究在Obesity在线发表。

Brown大学公共卫生学院Joseph M Braun博士介绍,PFAS(Perfluoroalkyl substances,全氟烃基类物质)被用于制作油和防水纺织涂料、不粘炊具、食品容器涂料、地板蜡、消防泡沫和工业表面活性剂。PFAS类物质具有生物蓄积性,一旦进入环境,极不容易被分解。PFAS是一大类疑似的肥胖原,并且在环境中和人类体内持久存在。

PFAS可以保护你的地毯不被弄脏,可以让食物不粘在包装纸或平底锅上,还可以让外套防雨。如果你下午茶喝咖啡的时候吃一块点心,用来包装点心的蜡纸上就可能覆盖一层PFAS物质。

一些啮齿动物实验和体外研究表明PFAS暴露可以扰乱体内葡萄糖代谢平衡,增加体重,改变脂肪细胞的分化。

这个研究中纳入在家的受试者,采用前瞻性队列研究检查早期暴露于环境中普遍存在的化学物质的影响。研究表明PFAS暴露与致胖之间存在剂量—反应关系,而且存在阈值效应。

是不是辛辛那提饮用水被污染的原因?

2003年3月—2003年1月,研究人员在辛辛那提9个产前诊所测量468名妊娠16 - 26周的女性产前血清样本中PFOA、PFOS(perfluorooctane
sulfonic,全氟辛烷磺酸)、PFNA(perfluorononanoic,全氟壬酸)和PFHxS(perfluorohexane sulfonic,全氟己烷磺酸)的含量。绝大多数(87%)的样品是在受试者妊娠16周时收集的。

研究人员排除多胎、死产和研究失访后,仍然有309例有效的单胎妊娠的活产儿童。研究人员比较了285例年龄在2-8岁的儿童(原始队列的73%)和204例(原始队列的73%52%)8岁儿童的体内PFAS浓度和BMIz分数、腰围、体脂肪。

数据来自于1021次研究随访,其中包括2岁儿童243例,3岁儿童219例,4岁儿童167例,5岁儿童188例,8岁儿童204例。

研究人员调整社会人口学协变量(孕产妇种族、年龄、教育、婚姻状况、就业以及家庭收入)和产前因素(产妇抑郁症状、在妊娠16周时孕产妇BMI、围产期和暴露于吸烟的产妇的血清尼古丁浓度)。研究还调查了产妇产前维生素的使用量和使用频率、怀孕期间。水果、蔬菜和鱼的消费量。

血清PFAS浓度分析前还调整产前尿BPA(bisphenol A,双酚A)的浓度,因为BPA是疑似的致胖原。

研究结果显示研究队列受试者体内PFOA平均浓度是参与2003-2004年和2005-2006年NHANES(National Health and Nutrition
Examination Surveys ,国家健康和营养调查)的孕妇NHANES检查结果的两倍多。

研究队列中的妇女血清PFOA浓度增高的原因可能是摄入被PFOA污染的饮用水,西弗吉尼亚州附近有杜邦公司的帕克斯堡工厂排放PFOA,这个工厂位于辛辛那提的俄亥俄河上游大约250英里。

杜邦公司报告说2000年以来这个工厂每年排放超过80000磅的PFOA到环境中。沿着俄亥俄河流淌的污染可能影响其他社区,包括辛辛那提市,因为居民的生活用水来源于俄亥俄河。

剂量反应关系

PFOA浓度与测量肥胖的三个措施(BMIz分数、腰围、体脂)之间的关联在PFOS浓度的50%时最明显,超过PFOS浓度的50%,这种关联性降低。检查PFOA三分位数和儿童肥胖数据,研究人员观察到类似的剂量—反应关系。

与孕母PFOA浓度处于第一个三分位数区间的儿童相比较,孕母PFOA浓度处于第二个三分位数区间(3.6%)和第三个三分位数区间 (1.5%)的儿童体脂增加的更迅速。

与孕母PFOA浓度处于第一个三分位数区间的儿童相比较,孕母PFOA浓度处于第二个三分位数区间的儿童在8岁时超重或肥胖的可能性增加了84%(RR 1.84),孕母PFOA浓度处于第三个三分位数区间的儿童在8岁时超重或肥胖的可能性增加了54%(RR
1.54)。

与孕母PFOA浓度处于第一个三分位数区间的儿童相比较,孕母PFOA浓度处于第二个三分位数区间的儿童的腰围增加了4.3cm。与孕母PFOA浓度处于第一个三分位数区间的儿童相比较,孕母PFOA浓度处于第三个三分位数区间的儿童的腰围增加了2.2cm。

与孕母PFOA浓度处于第一个三分位数区间的儿童相比较,孕母PFOA浓度处于第二个和第三个三分位数区间儿童从2岁到8岁增加的BMIz分数也更大。

调整尿BPA浓度、母乳喂养持续时间和产妇妊娠期体重增加后,研究结果仍然存在。

然而还需要进行更多的研究。其他纵向分析和包含儿童肥胖具体措施的前瞻性队列研究可以进一步证实这些发现。

研究由美国国立环境健康科学研究所提供资助。儿童铅中毒的公害案件的原告支付给布劳恩博士报酬,以报答布劳恩博士进行有关再分析儿童铅暴露的研究。合著者之间没有相关的财务关系。

监管部门的建议

2010年3月17日欧盟委员会发布2010/161/EU号议案,建议对食品中的全氟烷基物质(PFAS)进行监测。2010/161/EU建议欧盟成员国应在2010年和2011年间对食品中存在的全氟烷基物质进行监测。监测范围应包括反映消费习惯的各类食品,包括动物源性食品,如鱼、肉、蛋、奶及其制品和植物食品,以确保可精确评估全氟烷基物质的暴露量。

不粘锅涂层是由聚四氟乙烯加上其他助剂烧结而成,PFOA(全氟辛酸铵)是生产特富龙不粘锅使用的一种加工助剂,PFOA在生产过程中遇高温分解。

中国国家质量管理标准对不粘锅使用作了两个限制,一是不粘锅不能制作酸性食品,二是使用温度要限制在250℃以下。酸性食物包括各种肉类、蛋、白糖、大米等。

聚四氟乙烯结合强度不高,聚四氟乙烯涂层不能完全覆盖不粘锅,有些部位金属表面裸露在外。酸性物质容易腐蚀金属,金属锅体被腐蚀会膨胀,把涂层胀开,导致涂层大面积脱落。涂层只喷较薄的一层,结合有时并不牢靠,不可使用铁铲炒菜。

原始出处:

1.Childhood Obesity Link to Prenatal Exposure to Perfluoroalkyls. Medscape. November 23, 2015.

2.Joseph M Braun1, Aimin Chen, Megan E Romano. Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study. Obesity.Published online November 11,2015.

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createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52215, encodeId=db705221569, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461735, encodeId=dd121461e353a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502466, encodeId=82f015024665a, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552838, encodeId=af1f15528386b, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, 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    2017-06-08 卡圣

    学习了,谢谢

    0

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    2016-12-14 1e137bdcm70(暂无匿称)

    那我们应该用哪种锅呢

    0

  3. 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GetPortalCommentsPageByObjectIdResponse(id=1910474, encodeId=69b219104e487, content=<a href='/topic/show?id=faf7163606a' target=_blank style='color:#2F92EE;'>#SIT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16360, encryptionId=faf7163606a, topicName=SIT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102854, encodeId=a576102854fe, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Aug 24 10:16:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102853, encodeId=d82c10285372, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Aug 24 10:15:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52214, encodeId=abbb5221457, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52215, encodeId=db705221569, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461735, encodeId=dd121461e353a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502466, encodeId=82f015024665a, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552838, encodeId=af1f15528386b, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06814304969, createdName=windight, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=)]
    2016-03-30 智慧医人
  4. [GetPortalCommentsPageByObjectIdResponse(id=208268, encodeId=798c2082688a, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Thu Jun 08 21:32:18 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162833, encodeId=be0c16283379, content=那我们应该用哪种锅呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Wed Dec 14 20:56:38 CST 2016, time=2016-12-14, status=1, ipAttribution=), 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createdName=doctorJiangchao, createdTime=Wed Aug 24 10:16:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102853, encodeId=d82c10285372, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Aug 24 10:15:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52214, encodeId=abbb5221457, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52215, encodeId=db705221569, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461735, encodeId=dd121461e353a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502466, encodeId=82f015024665a, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552838, encodeId=af1f15528386b, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06814304969, createdName=windight, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=)]
    2016-08-24 doctorJiangchao

    继续关注

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=208268, encodeId=798c2082688a, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Thu Jun 08 21:32:18 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162833, encodeId=be0c16283379, content=那我们应该用哪种锅呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Wed Dec 14 20:56:38 CST 2016, time=2016-12-14, status=1, ipAttribution=), 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createdName=doctorJiangchao, createdTime=Wed Aug 24 10:16:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102853, encodeId=d82c10285372, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Aug 24 10:15:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52214, encodeId=abbb5221457, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52215, encodeId=db705221569, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461735, encodeId=dd121461e353a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502466, encodeId=82f015024665a, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552838, encodeId=af1f15528386b, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06814304969, createdName=windight, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=)]
    2016-08-24 doctorJiangchao

    继续学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=208268, encodeId=798c2082688a, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Thu Jun 08 21:32:18 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162833, encodeId=be0c16283379, content=那我们应该用哪种锅呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Wed Dec 14 20:56:38 CST 2016, time=2016-12-14, status=1, ipAttribution=), 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createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52215, encodeId=db705221569, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461735, encodeId=dd121461e353a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502466, encodeId=82f015024665a, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552838, encodeId=af1f15528386b, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06814304969, createdName=windight, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=)]
    2016-01-05 xyfg98

    值得关注

    0

  7. 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createdName=doctorJiangchao, createdTime=Wed Aug 24 10:16:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102853, encodeId=d82c10285372, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Aug 24 10:15:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52214, encodeId=abbb5221457, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52215, encodeId=db705221569, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461735, encodeId=dd121461e353a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502466, encodeId=82f015024665a, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552838, encodeId=af1f15528386b, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, 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    2016-01-05 xyfg98

    赞一个

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=208268, encodeId=798c2082688a, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Thu Jun 08 21:32:18 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162833, encodeId=be0c16283379, content=那我们应该用哪种锅呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Wed Dec 14 20:56:38 CST 2016, time=2016-12-14, status=1, ipAttribution=), 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createdName=doctorJiangchao, createdTime=Wed Aug 24 10:16:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102853, encodeId=d82c10285372, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Aug 24 10:15:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52214, encodeId=abbb5221457, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52215, encodeId=db705221569, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461735, encodeId=dd121461e353a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502466, encodeId=82f015024665a, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552838, encodeId=af1f15528386b, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06814304969, createdName=windight, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=)]
    2015-11-26 lingaifan
  9. [GetPortalCommentsPageByObjectIdResponse(id=208268, encodeId=798c2082688a, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Thu Jun 08 21:32:18 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162833, encodeId=be0c16283379, content=那我们应该用哪种锅呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82351961337, createdName=1e137bdcm70(暂无匿称), createdTime=Wed Dec 14 20:56:38 CST 2016, time=2016-12-14, status=1, ipAttribution=), 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createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52215, encodeId=db705221569, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 18:40:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461735, encodeId=dd121461e353a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502466, encodeId=82f015024665a, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552838, encodeId=af1f15528386b, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06814304969, createdName=windight, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=)]
    2015-11-26 qilu_qi
  10. 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13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502466, encodeId=82f015024665a, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Thu Nov 26 13:53:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552838, encodeId=af1f15528386b, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, 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肥胖已经成为儿童和成年人的严重疾病负担,因此备受公共卫生的关注。过去的研究表明,婴儿时期接触的环境因素可能对肥胖的发病风险有长期影响,而研究发病因素可能对降低肥胖的发病风险提供思路。为了研究婴儿期使用抗生素对幼儿肥胖的影响,费城儿童医院的Bailey LC医生对费城、宾夕法尼亚及其周边地区的儿童展开队列研究。该研究发表在近日的JAMA Pediatr上。研究者检索了2001-2013年的电子病历系

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成人中脂肪细胞的肥大或增生导致肥胖者体内脂肪量的增加,还常与脂肪组织的功能异常有关。本项研究中我们对171名0-18岁的正常和肥胖儿童进行全面综合的研究及临床特征的记录,并评估他们的脂肪组织样本在生物学及功能方面出现了哪些早期改变。 我们的研究发现,从儿童早期即可观察到肥胖者与正常组相比脂肪细胞体积和数量的增加。肥胖儿童脂肪组织组成的改变还伴随着体外实验中基础脂解水平的下降以及基质血管细胞增