BMJ:重度抑郁症初次治疗时使用二代抗抑郁药和认知行为疗法的利与弊(meta)

2015-12-09 sunshine译 MedSci原创

重度抑郁症成人患者使用二代抗抑郁药以及认知行为疗法(CBTs)的利与弊是怎样的?

重度抑郁症成人患者使用二代抗抑郁药以及认知行为疗法(CBTs)的利与弊是怎样的?

该系统性回顾使用随机和固定效应模型进行了定性分析和meta分析。研究人员检索了以下电子数据库:Medline、 Embase、 Cochrane图书馆、联合补充医学数据库、 PsycINFO以及护理和联合卫生文献累积索引,检索日期限制为1990年1月至2015年1月。共纳入了11项对比了二代抗抑郁药CBT应用的随机对照试验。10项试验对比了仅使用CBT与仅使用抗抑郁药的治疗效果;三项试验对比了仅使用抗抑郁药与使用抗抑郁药联合CBT的治疗效果。

Meta分析发现,二代抗抑郁药与CBT在治疗结果上并无统计学差异。同样,由于缺乏有效性,整体研究的停药率也无统计学差异。虽然越来越多的患者接受二代抗抑郁药治疗而不是接受CBT治疗,但是差异并无统计学意义。由于证据不足,不能得出其他的结果。由于大部分结果的证据力度不足,故该分析结果经谨慎对待。本次审查的范围有限,纳入的成年重度抑郁症患者并对比了二代抗抑郁药物与CBT的治疗效果,审查的许多试验存在方法上的缺陷,这些可能限制了分析结果的可信性。

循证医学证明了二代抗抑郁药和CBT治疗重度抑郁症的利与弊。目前并没有可用的证据表明两种治疗效果的差异,无论是单独使用还是联合使用。

原始出处:

H R Amick,et al. Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis. BMJ.2015

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    2016-07-21 wetgdt
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    2016-04-12 gaoxiaoe
  4. 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encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Feb 28 23:30:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887487, encodeId=4457188e48745, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Jan 14 03:30:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709808, encodeId=d4bc1e09808af, content=<a href='/topic/show?id=d6d591262e9' target=_blank style='color:#2F92EE;'>#认知行为#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91262, encryptionId=d6d591262e9, topicName=认知行为)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=250931794284, createdName=ms4468361851264128, createdTime=Sat Oct 01 00:30:00 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48594, encodeId=b74f4859422, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:39:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075986, encodeId=d78b20e598660, content=<a href='/topic/show?id=b1329003e13' target=_blank style='color:#2F92EE;'>#行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90037, encryptionId=b1329003e13, topicName=行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Fri Mar 25 03:30:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337690, encodeId=ac4d133e690a5, content=<a href='/topic/show?id=bf019126469' target=_blank style='color:#2F92EE;'>#认知行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91264, encryptionId=bf019126469, topicName=认知行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Fri Dec 11 05:30:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492141, encodeId=da16149214142, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Fri Dec 11 05:30:00 CST 2015, time=2015-12-11, status=1, ipAttribution=)]
    2016-02-28 一闲
  5. [GetPortalCommentsPageByObjectIdResponse(id=1722425, encodeId=36c51e224250a, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Thu Jul 21 16:30:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771354, encodeId=d9ea1e713548b, content=<a href='/topic/show?id=a6b123866c4' target=_blank style='color:#2F92EE;'>#二代抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23866, encryptionId=a6b123866c4, topicName=二代抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Apr 08 07:30:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847801, encodeId=b11f184e8015f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Apr 12 17:30:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895861, encodeId=791f189586172, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Feb 28 23:30:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887487, encodeId=4457188e48745, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Jan 14 03:30:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709808, encodeId=d4bc1e09808af, content=<a href='/topic/show?id=d6d591262e9' target=_blank style='color:#2F92EE;'>#认知行为#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91262, encryptionId=d6d591262e9, topicName=认知行为)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=250931794284, createdName=ms4468361851264128, createdTime=Sat Oct 01 00:30:00 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48594, encodeId=b74f4859422, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:39:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075986, encodeId=d78b20e598660, content=<a href='/topic/show?id=b1329003e13' target=_blank style='color:#2F92EE;'>#行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90037, encryptionId=b1329003e13, topicName=行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Fri Mar 25 03:30:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337690, encodeId=ac4d133e690a5, content=<a href='/topic/show?id=bf019126469' target=_blank style='color:#2F92EE;'>#认知行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91264, encryptionId=bf019126469, topicName=认知行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Fri Dec 11 05:30:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492141, encodeId=da16149214142, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Fri Dec 11 05:30:00 CST 2015, time=2015-12-11, status=1, ipAttribution=)]
    2016-01-14 guojianrong
  6. [GetPortalCommentsPageByObjectIdResponse(id=1722425, encodeId=36c51e224250a, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Thu Jul 21 16:30:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771354, encodeId=d9ea1e713548b, content=<a href='/topic/show?id=a6b123866c4' target=_blank style='color:#2F92EE;'>#二代抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23866, encryptionId=a6b123866c4, topicName=二代抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Apr 08 07:30:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847801, encodeId=b11f184e8015f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Apr 12 17:30:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895861, encodeId=791f189586172, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Feb 28 23:30:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887487, encodeId=4457188e48745, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Jan 14 03:30:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709808, encodeId=d4bc1e09808af, content=<a href='/topic/show?id=d6d591262e9' target=_blank style='color:#2F92EE;'>#认知行为#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91262, encryptionId=d6d591262e9, topicName=认知行为)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=250931794284, createdName=ms4468361851264128, createdTime=Sat Oct 01 00:30:00 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48594, encodeId=b74f4859422, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:39:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075986, encodeId=d78b20e598660, content=<a href='/topic/show?id=b1329003e13' target=_blank style='color:#2F92EE;'>#行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90037, encryptionId=b1329003e13, topicName=行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Fri Mar 25 03:30:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337690, encodeId=ac4d133e690a5, content=<a href='/topic/show?id=bf019126469' target=_blank style='color:#2F92EE;'>#认知行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91264, encryptionId=bf019126469, topicName=认知行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Fri Dec 11 05:30:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492141, encodeId=da16149214142, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Fri Dec 11 05:30:00 CST 2015, time=2015-12-11, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1722425, encodeId=36c51e224250a, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Thu Jul 21 16:30:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771354, encodeId=d9ea1e713548b, content=<a href='/topic/show?id=a6b123866c4' target=_blank style='color:#2F92EE;'>#二代抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23866, encryptionId=a6b123866c4, topicName=二代抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Apr 08 07:30:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847801, encodeId=b11f184e8015f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Apr 12 17:30:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895861, encodeId=791f189586172, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Feb 28 23:30:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887487, encodeId=4457188e48745, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Jan 14 03:30:00 CST 2016, time=2016-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709808, encodeId=d4bc1e09808af, content=<a href='/topic/show?id=d6d591262e9' target=_blank style='color:#2F92EE;'>#认知行为#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91262, encryptionId=d6d591262e9, topicName=认知行为)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=250931794284, createdName=ms4468361851264128, createdTime=Sat Oct 01 00:30:00 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48594, encodeId=b74f4859422, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:39:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075986, encodeId=d78b20e598660, content=<a href='/topic/show?id=b1329003e13' target=_blank style='color:#2F92EE;'>#行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90037, encryptionId=b1329003e13, topicName=行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Fri Mar 25 03:30:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337690, encodeId=ac4d133e690a5, content=<a href='/topic/show?id=bf019126469' target=_blank style='color:#2F92EE;'>#认知行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91264, encryptionId=bf019126469, topicName=认知行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Fri Dec 11 05:30:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492141, encodeId=da16149214142, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Fri Dec 11 05:30:00 CST 2015, time=2015-12-11, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

  8. 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  9. 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