Kidney Int:骨细胞中表达的klotho参与调控骨代谢和骨形成

2017-04-30 lishiting MedSci原创

矿化骨基质中的骨细胞通过调节成骨细胞和破骨细胞的活性进而调控着骨骼重建。研究发现,骨细胞中表达衰老抑制因子-klotho蛋白,但是这种蛋白对维持骨骼的动态平衡起到什么样的作用还未可知。这篇研究的目的是为了探讨骨细胞中的klotho基因是否参与调节了骨累积和骨形成。

矿化骨基质中的骨细胞通过调节成骨细胞和破骨细胞的活性进而调控着骨骼重建。研究发现,骨细胞中表达衰老抑制因子-klotho蛋白,但是这种蛋白对维持骨骼的动态平衡起到什么样的作用还未可知。这篇研究的目的是为了探讨骨细胞中的klotho基因是否参与调节了骨累积和骨形成。

结果显示,靶向删除骨细胞中的klotho基因可以明显促进骨形成和骨体积的增加,并且还可以显著提高成骨细胞的活性,但是却与在klotho亚等位基因(kl/kl)小鼠中观察到的结果截然相反。另外,在体外培养的成骨细胞中过表达klotho基因会抑制骨细胞分化过程中的矿化和成骨活性。进一步诱导小鼠慢性肾脏疾病的发生和发展并伴随肾性骨营养障碍的高转归致使骨细胞中klotho蛋白表达明显下降,这样看起来可以补偿因骨细胞靶向删除klotho基因而带来的骨影响。结果证实,骨细胞中的klotho表达是骨形成和骨累积有力的调控因子。

结论:这项研究表明,骨细胞中表达的klotho基因对于调节骨代谢起到至关重要的作用。同时,它也揭示了骨细胞调控骨形成可能存在的新机制。

原始出处:

Komaba H, Kaludjerovic J, et al. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. Kidney Int. 2017 Apr 8. pii: S0085-2538(17)30120-5. doi: 10.1016/j.kint.2017.02.014.

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRgMGrTMsyFTbqjY4eUCxaibAKa7YUIicpZOwFHzaupNKsgQz54PjE9ib7In7ndwpkppOSl9A8tBgDO9/0, createdBy=05222015381, createdName=1e1fd2a0m08(暂无匿称), createdTime=Mon May 01 20:39:31 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192597, encodeId=cf0919259edb, content=新。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwkLhxcwicLBb8936K4ooFu0qBSZ8tjY8TvILDLWWnxtSia9ib41D8DficwEicXSwfv8NCib0BFpyRibn2W/0, createdBy=1a4c2053791, createdName=136****4335, createdTime=Mon May 01 20:21:06 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192417, encodeId=15d919241e68, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Mon May 01 07:31:19 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192385, encodeId=ebed192385d8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Mon May 01 07:12:15 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192352, encodeId=c7861923520d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon May 01 06:41:45 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
    2017-05-02 gwc389
  5. 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GetPortalCommentsPageByObjectIdResponse(id=192352, encodeId=c7861923520d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon May 01 06:41:45 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
    2017-05-02 圣艮山

    这个东西越来越热了

    0

  6. 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content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Mon May 01 07:31:19 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192385, encodeId=ebed192385d8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Mon May 01 07:12:15 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192352, encodeId=c7861923520d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon May 01 06:41:45 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
    2017-05-01 1e1fd2a0m08(暂无匿称)

    该蛋白测定的试剂盒难买

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRgMGrTMsyFTbqjY4eUCxaibAKa7YUIicpZOwFHzaupNKsgQz54PjE9ib7In7ndwpkppOSl9A8tBgDO9/0, createdBy=05222015381, createdName=1e1fd2a0m08(暂无匿称), createdTime=Mon May 01 20:39:31 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192597, encodeId=cf0919259edb, content=新。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwkLhxcwicLBb8936K4ooFu0qBSZ8tjY8TvILDLWWnxtSia9ib41D8DficwEicXSwfv8NCib0BFpyRibn2W/0, createdBy=1a4c2053791, createdName=136****4335, createdTime=Mon May 01 20:21:06 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192417, encodeId=15d919241e68, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Mon May 01 07:31:19 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192385, encodeId=ebed192385d8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Mon May 01 07:12:15 CST 2017, time=2017-05-01, status=1, ipAttribution=), 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    2017-05-01 136****4335

    新。

    0

  8. 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    2017-05-01 医艺依意

    学习了谢谢分享

    0

  9. 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content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Mon May 01 07:31:19 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192385, encodeId=ebed192385d8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Mon May 01 07:12:15 CST 2017, time=2017-05-01, status=1, ipAttribution=), 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    2017-05-01 刘煜

    学习了谢谢分享

    0

  10. 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    2017-05-01 龙胆草

    学习了,谢谢分享

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