JACC:长QT综合征的预后较以往有明显改善!

2017-07-24 MedSci MedSci原创

长QT综合征(LQTS)是一种潜在致命性心脏病,患有LQTS的患者每年有1%-5%的概率出现晕厥、心跳骤停或心脏性猝死。近日,在国际心血管权威杂志JACC上发表了一篇旨在评估当代LQTS对患者预后影响的临床研究。本研究回顾分析了1999年1月至2015年10月至梅奥诊所就诊的606例LQTS患者(LQT1占47%,LQT2占34%,LQT3占9%)。突发的心脏不良事件(BCEs)定义为由LQTS引

长QT综合征(LQTS)是一种潜在致命性心脏病,患有LQTS的患者每年有1%-5%的概率出现晕厥、心跳骤停或心脏性猝死。近日,在国际心血管权威杂志JACC上发表了一篇旨在评估当代LQTS对患者预后影响的临床研究。

本研究回顾分析了1999年1月至2015年10月至梅奥诊所就诊的606例LQTS患者(LQT1占47%,LQT2占34%,LQT3占9%)。突发的心脏不良事件(BCEs)定义为由LQTS引起的晕厥或癫痫、心脏骤停、室颤和突发的心源性死亡。研究结果表明,共有166名(27%)患者至梅奥诊所初次就诊时即表现出LQTS症状,首发症状的平均年龄为12岁。在治疗方面,有47名患者(8%)没有积极接受治疗,有350名(58%)患者仅接受了β受体阻滞剂治疗,接受植入型心律转复除颤器的仅有25(4%)例,18例(3%)接受左心交感神经切除术,166例(27%)接受了联合治疗。随着平均长达6.7年的随访,有556例(92%)患者没有出现LQTS引起的BCE。在原来无症状的440名患者中,仅8名(2%)出现有一次BCE。相比之下,在原来有症状的166名患者中,有42名(25%)出现有≥1次的BCE。在30名出现有≥2次BCE的患者中,2名患者死亡,3名患者接受了心脏移植。

研究结果显示,现代的LQTS结局预后有明显改善,但是有四分之一既往有症状的患者出现过至少一次的突发心脏不良事件。LQTS的治疗策略仍需进一步优化。

原始出处:


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    2018-03-01 hbwxf
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    2017-07-24 1e0f8808m18(暂无匿称)

    好文章,实用研究

    0

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