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肺动脉高压治疗捷报：OPSUMIT显著改善右心室功能和肺血管阻力

2019-03-17 不详 网络

OPSUMIT肺动脉高压肺血管阻力
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Actelion制药公司近日宣布，通过对REPAIR研究的中期分析，发现OPSUMIT®（macitentan）治疗肺动脉高压（PAH）患者时，显著改善了右心室（RV）功能，包括RV重塑的逆转和肺血管阻力（PVR）的降低。这些数据将在第68届美国心脏病学会年度会议上公布。

Actelion制药公司近日宣布，通过对REPAIR研究的中期分析，发现OPSUMIT®（macitentan）治疗肺动脉高压（PAH）患者时，显著改善了右心室（RV）功能，包括RV重塑的逆转和肺血管阻力（PVR）的降低。这些数据将在第68届美国心脏病学会年度会议上公布。

REPAIR研究是一项为期52周，开放标签的多中心研究，评估OPSUMIT对心脏磁共振成像（MRI）和右心导管检查确定的RV重塑和功能的影响。对42例PAH患者的中期分析显示，两个主要终点均有显著改善，包括RV卒中量（RVSV）平均增加15.2 mL（p <0.0001），在第26周PVR从基线减少37％（p <0.0001）。科隆大学肺科高血压中心主任兼心血管研究中心（CCRC）负责人Stephan Rosenkranz说：“REPAIR研究的中期结果为OPSUMIT治疗这种严重和进展性疾病提供了更好的理论支撑”。


原始出处：

http://www.firstwordpharma.com/node/1629914#axzz5iPvQruud

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    2019-04-29 gracezdd

    #MIT#

    0

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    2019-08-13 jklm09

    #动脉高压#

    0

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    2019-10-16 shijzhiewnjhch

    #高压治疗#

    0

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    2019-11-24 smlt2008

    #肺血管阻力#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1900861, encodeId=e7c8190086168, content=<a href='/topic/show?id=5f9b119599d' target=_blank style='color:#2F92EE;'>#MIT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11959, encryptionId=5f9b119599d, topicName=MIT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Mon Apr 29 08:02:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925274, encodeId=44da19252e41b, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Aug 13 08:02:00 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822256, encodeId=38591822256fb, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Wed Oct 16 08:02:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951068, encodeId=6e04195106880, content=<a href='/topic/show?id=03b98232137' target=_blank style='color:#2F92EE;'>#肺血管阻力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82321, encryptionId=03b98232137, topicName=肺血管阻力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Nov 24 22:02:00 CST 2019, time=2019-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935829, encodeId=93bc193582975, content=<a href='/topic/show?id=39b5386288c' target=_blank style='color:#2F92EE;'>#右心室功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38628, encryptionId=39b5386288c, topicName=右心室功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3fb2500073, createdName=124987cdm26暂无昵称, createdTime=Sun Jun 23 22:02:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543759, encodeId=9f9c1543e5999, content=<a href='/topic/show?id=52d93862e06' target=_blank style='color:#2F92EE;'>#右心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38627, encryptionId=52d93862e06, topicName=右心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18d13610637, createdName=124988c7m99暂无昵称, createdTime=Tue Mar 19 09:02:00 CST 2019, time=2019-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050837, encodeId=ab7f105083e93, content=肺动脉高压表面是罕见病，事实上临床上并不少见，治疗药物虽然有一些，但是整体仍然不理解，可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Mar 17 21:02:00 CST 2019, time=2019-03-17, status=1, ipAttribution=)]
    2019-06-23 124987cdm26暂无昵称

    #右心室功能#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1900861, encodeId=e7c8190086168, content=<a href='/topic/show?id=5f9b119599d' target=_blank style='color:#2F92EE;'>#MIT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11959, encryptionId=5f9b119599d, topicName=MIT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Mon Apr 29 08:02:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925274, encodeId=44da19252e41b, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Aug 13 08:02:00 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822256, encodeId=38591822256fb, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Wed Oct 16 08:02:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951068, encodeId=6e04195106880, content=<a href='/topic/show?id=03b98232137' target=_blank style='color:#2F92EE;'>#肺血管阻力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82321, encryptionId=03b98232137, topicName=肺血管阻力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Nov 24 22:02:00 CST 2019, time=2019-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935829, encodeId=93bc193582975, content=<a href='/topic/show?id=39b5386288c' target=_blank style='color:#2F92EE;'>#右心室功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38628, encryptionId=39b5386288c, topicName=右心室功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3fb2500073, createdName=124987cdm26暂无昵称, createdTime=Sun Jun 23 22:02:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543759, encodeId=9f9c1543e5999, content=<a href='/topic/show?id=52d93862e06' target=_blank style='color:#2F92EE;'>#右心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38627, encryptionId=52d93862e06, topicName=右心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18d13610637, createdName=124988c7m99暂无昵称, createdTime=Tue Mar 19 09:02:00 CST 2019, time=2019-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050837, encodeId=ab7f105083e93, content=肺动脉高压表面是罕见病，事实上临床上并不少见，治疗药物虽然有一些，但是整体仍然不理解，可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Mar 17 21:02:00 CST 2019, time=2019-03-17, status=1, ipAttribution=)]
    2019-03-19 124988c7m99暂无昵称

    #右心室#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1900861, encodeId=e7c8190086168, content=<a href='/topic/show?id=5f9b119599d' target=_blank style='color:#2F92EE;'>#MIT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11959, encryptionId=5f9b119599d, topicName=MIT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Mon Apr 29 08:02:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925274, encodeId=44da19252e41b, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Aug 13 08:02:00 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822256, encodeId=38591822256fb, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Wed Oct 16 08:02:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951068, encodeId=6e04195106880, content=<a href='/topic/show?id=03b98232137' target=_blank style='color:#2F92EE;'>#肺血管阻力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82321, encryptionId=03b98232137, topicName=肺血管阻力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Nov 24 22:02:00 CST 2019, time=2019-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935829, encodeId=93bc193582975, content=<a href='/topic/show?id=39b5386288c' target=_blank style='color:#2F92EE;'>#右心室功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38628, encryptionId=39b5386288c, topicName=右心室功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3fb2500073, createdName=124987cdm26暂无昵称, createdTime=Sun Jun 23 22:02:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543759, encodeId=9f9c1543e5999, content=<a href='/topic/show?id=52d93862e06' target=_blank style='color:#2F92EE;'>#右心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38627, encryptionId=52d93862e06, topicName=右心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18d13610637, createdName=124988c7m99暂无昵称, createdTime=Tue Mar 19 09:02:00 CST 2019, time=2019-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050837, encodeId=ab7f105083e93, content=肺动脉高压表面是罕见病，事实上临床上并不少见，治疗药物虽然有一些，但是整体仍然不理解，可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Mar 17 21:02:00 CST 2019, time=2019-03-17, status=1, ipAttribution=)]
    2019-03-17 明天jing

    肺动脉高压表面是罕见病，事实上临床上并不少见，治疗药物虽然有一些，但是整体仍然不理解，可能未来需要采用综合治疗措施。

    0