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ACS Appl Mater Interfaces：基于白蛋白的智能纳米平台可增强癌症疗法的效果

2018-03-17 MedSci MedSci原创

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近年来，药物联合疗法为增强癌症治疗做出了巨大贡献。然而，由于复合药物制剂的药代动力学复杂，大多数组合策略在高剂量和体内较差的生物分布中显示出严重的副作用。为了克服这些缺陷并实现增强的癌症治疗，我们提出了一种构建基于白蛋白的智能纳米平台的方法，表示为K237-HSA-DC，用于编码环加氧酶-2（COX-2）抑制剂（塞来昔布）和化学治疗剂（多柔比星，DOX）。体外和体内研究均表明，与其他制剂相比，K2

近年来，药物联合疗法为增强癌症治疗做出了巨大贡献。然而，由于复合药物制剂的药代动力学复杂，大多数组合策略在高剂量和体内较差的生物分布中显示出严重的副作用。为了克服这些缺陷并实现增强的癌症治疗，我们提出了一种构建基于白蛋白的智能纳米平台的方法，表示为K237-HSA-DC，用于编码环加氧酶-2（COX-2）抑制剂（塞来昔布）和化学治疗剂（多柔比星，DOX）。

体外和体内研究均表明，与其他制剂相比，K237-HSA-DC对肿瘤细胞表现出最佳的治疗效果。此外，与其他制剂相比，K237-HSA-DC对正常器官的副作用较少。为了深入理解改善药物疗效背后的机制，我们进行了细胞代谢组学的机制研究，发现塞来昔布可以增强阿霉素对葡萄糖向细胞内转运的抑制作用，进而导致随后明显的能量代谢抑制。

基于以上研究发现的K237-HSA-DC的优点，我们相信，基于白蛋白的智能纳米平台可以作为增强癌症治疗的一种有前景的药物递送系统。

原始出处：

Shi L, Xu L, et al., Celecoxib-Induced Self-Assembly of Smart Albumin-Doxorubicin Conjugate for EnhancedCancer Therapy. ACS Appl Mater Interfaces. 2018 Mar 14;10(10):8555-8565. doi: 10.1021/acsami.8b00875. Epub 2018 Mar 2.

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    2019-02-16 夏天与十三菇凉

    #FAC#

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    2019-01-19 shanyongle

    #ACE#

    0

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    2018-05-03 mnda

    #癌症疗法#

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    2018-03-19 yaanren

    #ACS#

    0

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    2018-03-19 珙桐

    #白蛋白#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1956683, encodeId=d1dd1956683b3, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Sat Feb 16 06:25:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655846, encodeId=5838165584621, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Sat Jan 19 02:25:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752908, encodeId=5f681e52908f7, content=<a href='/topic/show?id=b103e1424b2' target=_blank style='color:#2F92EE;'>#癌症疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71424, encryptionId=b103e1424b2, topicName=癌症疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1e236589107, createdName=mnda, createdTime=Thu May 03 12:25:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279245, encodeId=48f512e9245d3, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Mon Mar 19 03:25:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304614, encodeId=a390130461407, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Mon Mar 19 03:25:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297103, encodeId=597929e103d1, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Mar 17 12:42:51 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-17 清风拂面

    谢谢分享学习

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