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Heart：肾脏去神经降压幅度与试验设计相关

2013-09-18 高晓方 译 医学论坛网

动态血压肾脏去神经
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英国一项研究表明，在实施双盲安慰剂对照的药物试验中，诊室和动态血压降低差异趋向于消失；肾脏去神经试验亦有可能随试验设计改进而出现类似表现。论文9月15日在线发表于《心脏》（Heart）。 肾脏去神经试验报告诊室收缩压降低30 mmHg，但动态血压降低远逊于此。上述差异可能具有生理学偏倚，并且在降压药物试验中亦可能出现。此项研究通过药物和肾脏去神经试验荟萃分析评估了诊室-动态血压

英国一项研究表明，在实施双盲安慰剂对照的药物试验中，诊室和动态血压降低差异趋向于消失；肾脏去神经试验亦有可能随试验设计改进而出现类似表现。论文9月15日在线发表于《心脏》（Heart）。

肾脏去神经试验报告诊室收缩压降低30 mmHg，但动态血压降低远逊于此。上述差异可能具有生理学偏倚，并且在降压药物试验中亦可能出现。此项研究通过药物和肾脏去神经试验荟萃分析评估了诊室-动态血压差异，共有包括4121例患者的31项药物试验以及包括720例患者的23项肾脏去神经试验符合纳入标准。

结果显示，在无随机或设盲的药物试验中，诊室血压降低幅度较动态血压增大5.6 mmHg（P<0.0001）。与之相反，在随机和设盲试验中，诊室与动态血压降低幅度基本一致（差异-0.88 mmHg）。肾脏去神经无随机设盲试验，其中诊室血压较治疗前和无干预对照组分别降低27.6和26.6 mmHg，动态血压则平均降低15.7 mmHg。

原文下载

Howard JP, Nowbar AN, Francis DP.Size of blood pressure reduction from renal denervation: insights from meta-analysis of antihypertensive drug trials of 4121 patients with focus on trial design: the CONVERGE report.Heart. 2013 Sep 15. doi: 10.1136/heartjnl-2013-304238.


       

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1291801, encodeId=3820129180139, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri Sep 20 01:17:00 CST 2013, time=2013-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355800, encodeId=3ee01355800f5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Sep 20 01:17:00 CST 2013, time=2013-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562192, encodeId=f990156219234, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Sep 20 01:17:00 CST 2013, time=2013-09-20, status=1, ipAttribution=)]
    2013-09-20 经常头晕

    #降压#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1291801, encodeId=3820129180139, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri Sep 20 01:17:00 CST 2013, time=2013-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355800, encodeId=3ee01355800f5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Sep 20 01:17:00 CST 2013, time=2013-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562192, encodeId=f990156219234, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Sep 20 01:17:00 CST 2013, time=2013-09-20, status=1, ipAttribution=)]
    2013-09-20 zhaojie88

    #ART#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1291801, encodeId=3820129180139, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri Sep 20 01:17:00 CST 2013, time=2013-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355800, encodeId=3ee01355800f5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Sep 20 01:17:00 CST 2013, time=2013-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562192, encodeId=f990156219234, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Sep 20 01:17:00 CST 2013, time=2013-09-20, status=1, ipAttribution=)]
    2013-09-20 slcumt

    #HEART#

    0