Cell撤稿丨噬菌体溶源化造成的人为假象

2018-03-03 佚名 BioArt

2月22日出版的Cell杂志中,有一篇题为“(p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity”的文章被撤稿,原因是过去论文中报道的表型是由于噬菌体溶源化造成的人为假象,文章中的结论将不再成立。

这篇Cell文章2013年8月发表,由英国纽卡斯尔大学(Newcastle University)Kenn Gerdes课题组完成,目前被引次数超过300次。

2013年的这篇论文主要描述的是,报道了一种呈指数生长的野生型大肠杆菌群体产生的少量随机转换为生长缓慢的持留菌(persisters),这些持留菌具有多重药物耐受性。而产生的上述表型的分子机制被认为是依赖于一连串的信号分子,包括鸟苷四磷酸(p)ppGpp、Lon蛋白酶、无机物多磷酸盐和毒素-抗毒素模块(toxin-antitoxin modules,TA模块),认为鸟苷四磷酸(p)ppGpp水平的高低是调控持留菌的主要因素,(p)ppGpp可以通过无机多磷酸盐和Lon蛋白激酶启动TA模块。

研究人员基于这篇论文进行其它新的系列实验的时候发现,用于感染的突变大肠杆菌菌株产生的系列表型是由于噬菌体溶源化造成的假象得到的。该文由作者主动撤稿

注:持留菌这一概念于1944年由Joseph Bigger教授提出。阿莫西林加入葡萄球菌忠后,大部分菌株死亡,但是仍有少数存活的菌株,这些菌株被称为持留菌。

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    2018-12-11 维他命
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    2018-03-03 1dd8c52fm63(暂无匿称)

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