DIABETOLOGIA:使用碳水化合物计数和灵活的胰岛素治疗的1型糖尿病妇女夜间母乳喂养很少发生低血糖症

2019-04-03 不详 网络

<span lang="EN-US" style="font-size:9.0pt;mso-bidi-font-size: 11.0pt">1<span style="font-size:9.0pt;mso-bidi-font-size:11.0pt; font-family:宋体;mso-ascii-font-family:Calibri;mso-ascii-theme-font:minor

1糖尿病母亲担心与母乳喂养相关的低血糖症疾病。因此,尽管缺乏证据,但常建议在每次母乳喂养时,特别是在晚上摄入常规的碳水化合物。本研究的目的是评估母乳喂养期间的葡萄糖水平,研究重点关注夜间母乳喂养是否会引起1糖尿病母亲的低血糖

在单胎分娩后1个月,研究人员前瞻性纳入连续43例患有1糖尿病的母亲中33例(77%)。26名母亲(平均[SD]年龄30.7 [5.8]年,平均[SD]糖尿病持续时间18.6 [10.3]年)是母乳喂养和7名母亲(平均[SD]年龄31.7 [5.6]年,平均[SD]糖尿病的持续时间为20.4 [6.2]年)用配方奶喂养。使用胰岛素类似物进行单独定制的胰岛素治疗(胰岛素泵为45%,每日多次注射为55%),所有人都有碳水化合物计数经验。将321型糖尿病女性,年龄±1岁,BMI±1 kg / m 2在前一年没有分娩或母乳喂养的人作为对照组。在产后1个月,2个月和6个月对在每个CGM期记录母乳喂养和碳水化合物摄入量的母乳喂养母亲施加盲法连续葡萄糖监测(CGM6天。产后1个月应用CGM对配方奶喂养的母亲进行治疗,对照组应用一次。在每个CGM期后,单独定制胰岛素剂量。

结果显示,CGM <4.0 mmol / l时夜间花费的百分比较低(母乳喂养母亲每个CGM期间为4.6%,3.1%和2.7%,对照组为1.6%,p  = 0.77),母乳喂养的母亲在目标范围4.0-10.0 mmol / lp  = 0.01)中花费了更大比例的夜间时间。在产后母亲和对照妇女中,症状性低血糖在产后1个月,2个月和6个月每周发生两次或三次。一名母亲(3%)在产后6个月和一名对照女性(3%)报告了严重的低血糖(p  = 0.74)。在1个月的母乳喂养母亲中,胰岛素剂量比怀孕前低18%(-67%至+ 48%)(p = 0.04)。总共,与438个记录的夜间母乳喂养相比,碳水化合物没有被消耗,并且在这些母乳喂养的20个(4.6%)之后3小时内CGM <4.0mmol / l

结论表明,患有1型糖尿病的母乳喂养母亲夜间发生低血糖的比例较低,而对照组妇女夜间发生低血糖的比例也很相似。夜间母乳喂养很少引起低血糖。以往建议在夜间母乳喂养时常规摄入碳水化合物的建议,对于适当减少胰岛素剂量、摄入足够碳水化合物的1型糖尿病母亲来说,此类建议可能已经过时。

原始出处:

Lene RingholmAnn B. Roskjær,Breastfeeding at night is rarely followed by hypoglycaemia in women with type 1 diabetes using carbohydrate counting and flexible insulin therapy

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2019-04-22 智慧医人
  4. [GetPortalCommentsPageByObjectIdResponse(id=1906412, encodeId=15121906412de, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Wed Aug 21 21:25:00 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639037, encodeId=d9d7163903efe, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Feb 11 18:25:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761048, encodeId=3bdd1e61048f6, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Apr 22 13:25:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665074, encodeId=64d716650e46a, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, 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objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457799, encodeId=0111145e7999e, content=<a href='/topic/show?id=b63926366a2' target=_blank style='color:#2F92EE;'>#低血糖症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26366, encryptionId=b63926366a2, topicName=低血糖症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b0b5986082, createdName=appleandpeer, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464379, encodeId=4bb314643e9eb, content=<a href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514655, encodeId=a0b215146555d, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042337, encodeId=a08b104233e5f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Apr 03 22:25:00 CST 2019, time=2019-04-03, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1906412, encodeId=15121906412de, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Wed Aug 21 21:25:00 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639037, encodeId=d9d7163903efe, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, 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objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457799, encodeId=0111145e7999e, content=<a href='/topic/show?id=b63926366a2' target=_blank style='color:#2F92EE;'>#低血糖症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26366, encryptionId=b63926366a2, topicName=低血糖症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b0b5986082, createdName=appleandpeer, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464379, encodeId=4bb314643e9eb, content=<a href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514655, encodeId=a0b215146555d, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042337, encodeId=a08b104233e5f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Apr 03 22:25:00 CST 2019, time=2019-04-03, status=1, ipAttribution=)]
    2019-06-12 baoya
  6. [GetPortalCommentsPageByObjectIdResponse(id=1906412, encodeId=15121906412de, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Wed Aug 21 21:25:00 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639037, encodeId=d9d7163903efe, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, 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objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457799, encodeId=0111145e7999e, content=<a href='/topic/show?id=b63926366a2' target=_blank style='color:#2F92EE;'>#低血糖症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26366, encryptionId=b63926366a2, topicName=低血糖症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b0b5986082, createdName=appleandpeer, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464379, encodeId=4bb314643e9eb, content=<a href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514655, encodeId=a0b215146555d, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042337, encodeId=a08b104233e5f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Apr 03 22:25:00 CST 2019, time=2019-04-03, status=1, ipAttribution=)]
    2019-04-05 villahu
  7. [GetPortalCommentsPageByObjectIdResponse(id=1906412, encodeId=15121906412de, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Wed Aug 21 21:25:00 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639037, encodeId=d9d7163903efe, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, 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content=<a href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514655, encodeId=a0b215146555d, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Apr 05 10:25:00 CST 2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042337, encodeId=a08b104233e5f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Apr 03 22:25:00 CST 2019, time=2019-04-03, status=1, ipAttribution=)]
  8. 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2019, time=2019-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042337, encodeId=a08b104233e5f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Apr 03 22:25:00 CST 2019, time=2019-04-03, status=1, ipAttribution=)]
    2019-04-05 yuanming9
  9. 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    2019-04-03 misszhang

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