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CLIN CANCER RES：AZD4547治疗晚期鳞状细胞肺癌患者

2017-09-20 MedSci MedSci原创

鳞状细胞肺癌AZD4547临床试验
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鳞状细胞肺癌约占非小细胞肺癌的25%，此类患者预后较差，可选择的治疗方式有限。FGFR1过表达是鳞状细胞肺癌最常见的致癌原因之一，约在20%的患者中存在。AZD4547是选择性FGFR1-3抑制剂，在鳞状细胞肺癌细胞系及异种移植模型中具有抗肿瘤活性。CLIN CANCER RES近期发表了一篇文章， 报道了AZD4547治疗鳞状细胞肺癌患者的临床试验结果。

鳞状细胞肺癌约占非小细胞肺癌的25%，此类患者预后较差，可选择的治疗方式有限。FGFR1过表达是鳞状细胞肺癌最常见的致癌原因之一，约在20%的患者中存在。AZD4547是选择性FGFR1-3抑制剂，在鳞状细胞肺癌细胞系及异种移植模型中具有抗肿瘤活性。CLIN CANCER RES近期发表了一篇文章， 报道了AZD4547治疗鳞状细胞肺癌患者的临床试验结果。研究纳入的患者为接受过治疗的Ⅳ期FGFR1过表达鳞状细胞肺癌患者。使用FISH法鉴定FGFR1过表达（FGFR1：CEP8≥2）。主要的研究终点为安全性/耐受性。次要的研究终点包括抗肿瘤活性，药代动力学，药效学和分子分析。研究共纳入15例FGFR1过表达患者。最常见的治疗相关不良反应为胃肠道和皮肤反应。3例患者出现3级及以上不良反应。13例患者可以进行影像学治疗反应评估。总反应率为8%。15例患者中2例患者在12周出现无病情进展，平均总生存期为4.9周。分子检测，包括二代测序，基因表达分析和FGFR1免疫组化分析表明基因扩增与表达，潜在的疗效基因修饰和8p11扩增异质性关系不明显。文章最后认为，AZD4547在剂量为80mg口服每天2

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1990608, encodeId=088e19906086c, content=<a href='/topic/show?id=5739822223f' target=_blank style='color:#2F92EE;'>#肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82222, encryptionId=5739822223f, topicName=肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Wed Apr 11 11:28:00 CST 2018, time=2018-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1714749, encodeId=e25c1e1474932, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Sat Apr 07 18:28:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246207, encodeId=d94224620ef6, content=文章很好.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 21 06:51:23 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245973, encodeId=f7802459e366, content=肺癌的发病率高.希望能彻底治愈, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Sep 20 10:28:00 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2018-04-11 gds2009

    #肺癌患者#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1990608, encodeId=088e19906086c, content=<a href='/topic/show?id=5739822223f' target=_blank style='color:#2F92EE;'>#肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82222, encryptionId=5739822223f, topicName=肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Wed Apr 11 11:28:00 CST 2018, time=2018-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1714749, encodeId=e25c1e1474932, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Sat Apr 07 18:28:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246207, encodeId=d94224620ef6, content=文章很好.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 21 06:51:23 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245973, encodeId=f7802459e366, content=肺癌的发病率高.希望能彻底治愈, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Sep 20 10:28:00 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2018-04-07 12498e5fm22(暂无昵称)

    #AZ#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1990608, encodeId=088e19906086c, content=<a href='/topic/show?id=5739822223f' target=_blank style='color:#2F92EE;'>#肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82222, encryptionId=5739822223f, topicName=肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Wed Apr 11 11:28:00 CST 2018, time=2018-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1714749, encodeId=e25c1e1474932, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Sat Apr 07 18:28:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246207, encodeId=d94224620ef6, content=文章很好.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 21 06:51:23 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245973, encodeId=f7802459e366, content=肺癌的发病率高.希望能彻底治愈, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Sep 20 10:28:00 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-21 1e10c84am36(暂无匿称)

    文章很好.值得分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1990608, encodeId=088e19906086c, content=<a href='/topic/show?id=5739822223f' target=_blank style='color:#2F92EE;'>#肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82222, encryptionId=5739822223f, topicName=肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Wed Apr 11 11:28:00 CST 2018, time=2018-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1714749, encodeId=e25c1e1474932, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Sat Apr 07 18:28:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246207, encodeId=d94224620ef6, content=文章很好.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 21 06:51:23 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245973, encodeId=f7802459e366, content=肺癌的发病率高.希望能彻底治愈, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Sep 20 10:28:00 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 flysky120

    肺癌的发病率高.希望能彻底治愈

    0

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