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Nanomed：多功能MBCS可有效抗肿瘤并促进骨再生

2018-01-24 MedSci MedSci原创

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为了有效治疗肿瘤相关骨缺损，设计并制备多功能生物材料仍然是一个巨大的挑战。本研究中，研究人员制备了磁性SrFe12O19纳米粒子修饰的介孔生物玻璃（BG）/壳聚糖（CS）多孔支架（MBCS），具有优异的骨再生和抗肿瘤功能。 实验分析显示，MBCS产生的磁场促进成骨相关基因（OCN、COL1、Runx2和ALP）的表达，并可通过活化BMP-2/Smad/Runx2通路促进新骨再生。而且，MBCS中的

为了有效治疗肿瘤相关骨缺损，设计并制备多功能生物材料仍然是一个巨大的挑战。本研究中，研究人员制备了磁性SrFe12O19纳米粒子修饰的介孔生物玻璃（BG）/壳聚糖（CS）多孔支架（MBCS），具有优异的骨再生和抗肿瘤功能。

实验分析显示，MBCS产生的磁场促进成骨相关基因（OCN、COL1、Runx2和ALP）的表达，并可通过活化BMP-2/Smad/Runx2通路促进新骨再生。而且，MBCS中的SrFe12O19纳米颗粒改善了光热转换性能。在近红外（NIR）激光照射下，与MBCS共培养的肿瘤温度升高引发肿瘤细胞的凋亡和消融。与纯支架组相比，MBCS/NIR通过热疗消融具有良好的抗骨肉瘤作用。

综上所述，该研究结果表明，多功能MBCS具有优异的骨再生和光热疗功能，在治疗肿瘤相关性骨缺损方面具有很大的应用价值。

原始出处：

Lu JW, Yang F, et al., Magnetic Nanoparticles Modified-Porous Scaffolds for Bone Regeneration and Photothermal Therapy against Tumors. Nanomedicine. 2018 Jan 12. pii: S1549-9634(18)30012-1. doi: 10.1016/j.nano.2017.12.025. 

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    2018-01-26 lsj630

    #骨再生#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1472108, encodeId=01ea14e210886, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Jan 26 00:40:00 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608474, encodeId=51d116084e40c, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jan 26 00:40:00 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281525, encodeId=2fe7281525a8, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jan 24 09:51:56 CST 2018, time=2018-01-24, status=1, ipAttribution=)]
    2018-01-26 ms3994565386320060

    #Med#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1472108, encodeId=01ea14e210886, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Jan 26 00:40:00 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608474, encodeId=51d116084e40c, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jan 26 00:40:00 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281525, encodeId=2fe7281525a8, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jan 24 09:51:56 CST 2018, time=2018-01-24, status=1, ipAttribution=)]
    2018-01-24 龙胆草

    学习谢谢分享

    0