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J Dent Res：研究揭示牙周韧带适应软硬食物咀嚼变化的机制

2019-03-24 不详 网络

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软食饮食会导致牙周韧带（PDL）的变化，其原因在于机械负载的改变。尽管这些适应性反应已被充分表征，但这些变化背后的分子、细胞和机械机制却尚未明了。本研究中，我们将PDT信号传递到PDL对欠载的响应的病理学中。结果表明，PDL空间中的Wnt响应细胞及其后代在咀嚼时表现出增殖突变。如果动物从断奶时开始喂食软饮食，那么这种Wnt反应性细胞增殖的爆发就会被平息；结果，PDL和周围的牙槽骨都发生萎缩 将这些

软食饮食会导致牙周韧带（PDL）的变化，其原因在于机械负载的改变。尽管这些适应性反应已被充分表征，但这些变化背后的分子、细胞和机械机制却尚未明了。

本研究中，我们将PDT信号传递到PDL对欠载的响应的病理学中。结果表明，PDL空间中的Wnt响应细胞及其后代在咀嚼时表现出增殖突变。如果动物从断奶时开始喂食软饮食，那么这种Wnt反应性细胞增殖的爆发就会被平息；结果，PDL和周围的牙槽骨都发生萎缩 将这些动物返回到硬食食物中可恢复PDL中的Wnt信号传导。

总之，该研究结果首次提供了PDL对加载的自适应响应的潜在分子机制。

原始出处：

Zhang X, Yuan X, et al., Molecular Basis for Periodontal Ligament Adaptation to In Vivo Loading. J Dent Res. 2019 Mar;98(3):331-338. doi: 10.1177/0022034518817305. Epub 2019 Jan 5.

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    2020-02-22 Boyinsh

    #咀嚼#

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    2020-02-21 w363522458

    #牙周韧带#

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    2019-03-26 yhy100201

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    2019-03-26 医者仁心

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    2019-03-26 juliusluan81

    #韧带#

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