JACC:严重主动脉瓣狭窄和冠脉疾病患者TAVR术后的冠脉血流动力学

2018-10-16 xiangting MedSci原创

TAVR术后收缩期和充血冠脉血流显著增加。

这项研究中,对接受经导管主动脉瓣置换术(TAVR)的严重主动脉瓣狭窄(AS)和冠脉病患者的阶段性冠脉内压和血流速度进行了系统分析,以确定AS如何影响:1)阶段性冠脉血流; 2)充血冠脉血流; 3)临床上最常用的冠脉狭窄程度指标、瞬时无波比和血流储备分数。

严重主动脉瓣狭窄(AS)患者中很大一部分伴有冠脉病。目前尚未研究瓣膜对冠脉压力、血流量和已知狭窄严重程度侵入性临床指标的影响。

研究纳入28例严重AS和冠脉疾病患者(30个病灶,50.0%为男性,平均年龄82.1±6.5岁)。在TAVR术前即刻和术后静息时和充血期间进行冠脉内压力和血流量评估。

TAVR术后舒张期无波期间的血流量没有变化(29.78±14.9cm/s vs. 30.81±19.6cm/s;p=0.64)。TAVR术后整个周期充血流量显著增加(TAVR术前33.44±13.4cm/s vs. TAVR术后40.33±17.4cm/s;p=0.006);这继发于TAVR术后收缩期充血流量的显著增加(TAVR术前27.67±12.1cm/s vs. TAVR术后34.15±17.5 cm/s;p=0.02)。瞬时无波比值在TAVR术后没有变化(TAVR术前0.88±0.09 vs. TAVR术后0.88±0.09;p=0.73),而TAVR术后血流储备分数显著下降(TAVR术前0.87±0.08  vs. TAVR术后0.85±0.09;p=0.001)。

TAVR术后收缩期和充血冠脉血流显著增加;因此,包括收缩期的充血指标低估了严重AS患者的冠脉狭窄严重程度。舒张期无波期间的血流在TAVR术后没有变化,这表明在此期间计算的指标不易受到狭窄主动脉瓣的混杂影响。

原始出处:

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392019, encodeId=f897139201995, content=<a href='/topic/show?id=3704891621c' target=_blank style='color:#2F92EE;'>#血流动力学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89162, encryptionId=3704891621c, topicName=血流动力学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Thu Oct 18 07:34:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415388, encodeId=3ddc1415388f4, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Oct 18 07:34:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1572984, encodeId=64e915e298440, content=<a href='/topic/show?id=805d3098599' target=_blank style='color:#2F92EE;'>#冠脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30985, encryptionId=805d3098599, topicName=冠脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb3e15794072, createdName=huangshifeng, createdTime=Thu Oct 18 07:34:00 CST 2018, time=2018-10-18, status=1, ipAttribution=)]
    2019-05-07 hbwxf
  5. 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  6. 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  7. 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该分析显示在这个队列中,基线右束支传导阻滞和TAVR后PR长度增加数量是TAVR后需要进行PPM置换的晚期(≥48h)高度传导障碍独立预测因子。

Circulation:严重主动脉瓣狭窄患者心肌瘢痕与死亡率

由此可见,在严重AS患者中,心肌瘢痕与死亡率独立相关;它的存在与后期死亡率增加2倍有关。

Circulation:蛋白质组学生物标志物可预测需瓣膜置换的主动脉瓣狭窄

主动脉瓣狭窄(AS)是心脏瓣膜手术最常见的适应证,若不治疗死亡率非常高。目前,AS的病因学尚不清楚。既往相关人体研究通常为病例对照研究,开展前瞻性研究探寻可预测需瓣膜置换的AS生物标志物有望为我们认识AS的机制提供新见解。

JACC:经导管主动脉瓣置换术后早期放电与标准放电的比较

在出院至30天死亡率或出院后PPI需求方面,无并发症TAVR后的ED是安全的。

JACC:使用Edwards Sapien 3瓣膜的超大瓣环TAVR中主动脉根部解剖和几何形状对瓣周漏的影响

通过过度膨胀使用超过推荐范围的29-mm S3瓣膜进行TAVR是安全的,PVL和起搏器植入率在可接受范围。