Hepatology: 酒精摄入对非酒精性脂肪性肝病患者死亡率的影响

2019-08-17 不详 MedSci原创

非酒精性脂肪性肝病(NAFLD)在美国是主要的慢性肝病患者,酒精摄入对NAFLD患者生存的影响尚不清楚。因此本项研究旨在探究二者之间的关系。

背景:
非酒精性脂肪性肝病(NAFLD)在美国是主要的慢性肝病患者,酒精摄入对NAFLD患者生存的影响尚不清楚。因此本项研究旨在探究二者之间的关系。

方法:
研究人员搜索了1988年至2010年美国国家健康和营养检查数据库,并将其与国家死亡指数联系起来,以便对患者的生存进行随访。同时使用多变量Cox比例风险模型来评估酒精消费对NAFLD患者生存的影响。排除有大量饮酒,病毒性肝炎或转铁蛋白饱和度增加的参与者后,共有4568名NAFLD参与者被纳入本项研究。在根据年龄,性别和吸烟史调整的Cox模型中,与不饮酒相比。每天饮用≥1.5次饮酒表现出肝脏有害的趋势(HR = 1.16,95%CI 0.99-1.36,P = 0.119)。在进一步调整种族,体力活动,受教育程度,糖尿病,纤维和多不饱和脂肪酸摄入量后,每天饮用0.5-1.5份饮料显示出显着的保护作用(HR = 0.64,95%CI 0.42-0.97,P = 0.035),每天饮用≥1.5饮料对死亡率有显着的危害(HR = 1.45,95%CI 1.01-2.10,P= 0.047)。

结论:
在NAFLD患者中,适度饮酒与全因死亡率显着降低有关,而每天饮用≥1.5次饮酒则与死亡率增加有关。这些结果有助于讨论NAFLD患者饮酒的潜在风险和益处。

原始出处:

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    2020-05-11 qjddjq
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    2019-09-21 liujie6118

    酒精摄入对NAFLD患者生存的影响尚不清楚

    0

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    2019-08-19 gwc384

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