Circulation:心力衰竭患者接受冠脉搭桥术的猝死危险因素

2017-02-11 MedSci MedSci原创

冠脉搭桥术(CABG)后的心力衰竭患者中发生心脏性猝死(SCD)的风险在目前的临床试验中没有相关研究。近期,一项发表在杂志Circulation上的研究分析描述了CABG后SCD的发生率、时间和临床预测因子。此项研究受试者为加入缺血性心力衰竭手术治疗(STICH)试验的人群,包括接受伴有或不伴有手术心室重建(SVR)的CABG患者。排除了先前ICD的患者和随机分配到药物治疗的患者。主要结果是由盲法

冠脉搭桥术(CABG)后的心力衰竭患者中发生心脏性猝死(SCD)的风险在目前的临床试验中没有相关研究。


近期,一项发表在杂志Circulation上的研究分析描述了CABG后SCD的发生率、时间和临床预测因子。

此项研究受试者为加入缺血性心力衰竭手术治疗(STICH)试验的人群,包括接受伴有或不伴有手术心室重建(SVR)的CABG患者。排除了先前ICD的患者和随机分配到药物治疗的患者。主要结果是由盲法委员会裁定的SCD。Cox模型用于检查和识别SCD的预测因子。使用Fine和Gray方法来估计SCD对其他死亡的竞争风险的发生率。

研究结果显示:中位随访时间为46个月,接受不伴有(n = 934)或伴有SVR(n = 477)的1411例CABG患者中,有113例患者发生SCD;311名患者死于其他原因。

入选时的平均LVEF为28±9%。SCD的5年累积发病率为8.5%。患有SCD和未死亡的患者年龄较小,且与因SCD以外的原因死亡的患者相比,共患病症较少。

在CABG后的前30天,SCD(n = 5)占所有死亡的7%。 发生SCD的月最大值在31-90天时间段内。在包括基线人口统计学、风险因素、冠状动脉解剖和LV功能的多变量分析中,ESVI和BNP与SCD强烈关联。

此项研究结果表明:在第一个月和第三个月之间,低LVEF患者接受CABG后发生SCD的月风险最高,表明SCD的风险分层可能在术后早期发生,特别是在术前ESVI和/或BNP增加的患者中。

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    2017-02-15 1771ae4158m

    学习一下很不错

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1682071, encodeId=bd2c16820e19e, content=<a href='/topic/show?id=202b309688b' target=_blank style='color:#2F92EE;'>#冠脉搭桥术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30968, encryptionId=202b309688b, topicName=冠脉搭桥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41e27933971, createdName=ZGMFX33A, createdTime=Sun Feb 19 04:05:00 CST 2017, time=2017-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663900, encodeId=cf1216639001c, content=<a href='/topic/show?id=03a35691e2e' target=_blank style='color:#2F92EE;'>#搭桥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56917, encryptionId=03a35691e2e, topicName=搭桥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=557f25711234, createdName=12498b3em16(暂无昵称), createdTime=Wed Sep 20 14:05:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176177, encodeId=d50f1e6177f2, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Wed Feb 15 00:19:03 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492357, encodeId=9afc149235efb, content=<a href='/topic/show?id=a251569194f' target=_blank style='color:#2F92EE;'>#搭桥术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56919, encryptionId=a251569194f, topicName=搭桥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32a28924986, createdName=zzc2214, createdTime=Mon Feb 13 06:05:00 CST 2017, time=2017-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552900, encodeId=0f19155290046, content=<a href='/topic/show?id=696730966a0' target=_blank style='color:#2F92EE;'>#冠脉搭桥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30966, encryptionId=696730966a0, topicName=冠脉搭桥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=710114309336, createdName=yese, createdTime=Mon Feb 13 06:05:00 CST 2017, time=2017-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175685, encodeId=c64b1e5685b8, content=学习一下,涨知识!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Feb 12 06:56:52 CST 2017, time=2017-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175626, encodeId=6b0e1e56268f, content=值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Sat Feb 11 18:48:32 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175625, encodeId=08691e562514, content=这篇文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Sat Feb 11 18:47:54 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175622, encodeId=c8a51e562277, content=很好的学习资料,感谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Sat Feb 11 18:26:16 CST 2017, time=2017-02-11, status=1, ipAttribution=)]
    2017-02-13 zzc2214
  5. [GetPortalCommentsPageByObjectIdResponse(id=1682071, encodeId=bd2c16820e19e, content=<a href='/topic/show?id=202b309688b' target=_blank style='color:#2F92EE;'>#冠脉搭桥术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30968, encryptionId=202b309688b, topicName=冠脉搭桥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41e27933971, createdName=ZGMFX33A, createdTime=Sun Feb 19 04:05:00 CST 2017, time=2017-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663900, encodeId=cf1216639001c, content=<a href='/topic/show?id=03a35691e2e' target=_blank style='color:#2F92EE;'>#搭桥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56917, encryptionId=03a35691e2e, topicName=搭桥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=557f25711234, createdName=12498b3em16(暂无昵称), createdTime=Wed Sep 20 14:05:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176177, encodeId=d50f1e6177f2, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Wed Feb 15 00:19:03 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492357, encodeId=9afc149235efb, content=<a href='/topic/show?id=a251569194f' target=_blank style='color:#2F92EE;'>#搭桥术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56919, encryptionId=a251569194f, topicName=搭桥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32a28924986, createdName=zzc2214, createdTime=Mon Feb 13 06:05:00 CST 2017, time=2017-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552900, encodeId=0f19155290046, content=<a href='/topic/show?id=696730966a0' target=_blank style='color:#2F92EE;'>#冠脉搭桥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30966, encryptionId=696730966a0, topicName=冠脉搭桥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=710114309336, createdName=yese, createdTime=Mon Feb 13 06:05:00 CST 2017, time=2017-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175685, encodeId=c64b1e5685b8, content=学习一下,涨知识!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Feb 12 06:56:52 CST 2017, time=2017-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175626, encodeId=6b0e1e56268f, content=值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Sat Feb 11 18:48:32 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175625, encodeId=08691e562514, content=这篇文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Sat Feb 11 18:47:54 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175622, encodeId=c8a51e562277, content=很好的学习资料,感谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Sat Feb 11 18:26:16 CST 2017, time=2017-02-11, status=1, ipAttribution=)]
    2017-02-13 yese
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    2017-02-12 老段

    学习一下,涨知识!!

    0

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    2017-02-11 milkshark

    值得收藏

    0

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    2017-02-11 milkshark

    这篇文章不错

    0

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    2017-02-11 1e15b6fem30(暂无匿称)

    很好的学习资料,感谢了。

    0

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