Chest:COVID-19与H1N1所致急性呼吸窘迫综合征住院患者的比较

2020-03-28 MedSci原创 MedSci原创

COVID-19与H1N1所致的ARDS在临床表现上存在诸多差异。与H1N1相比,COVID-19所致的ARDS患者在就诊时的疾病严重程度评分较低,经SOFA评分调整的死亡率较低。

自2019年12月,爆发2019年冠状病毒病(COVID-19)以来,对阐明其来源和表现引起了广泛关注。然而,临床医生和流行病学家将COVID-19与其他呼吸道传染病(如流感病毒)区分开来也很重要。近日,呼吸领域权威杂志chest上发表了一篇研究文章,该研究旨在探讨COVID-19与甲型H1N1流感肺炎所致的急性呼吸窘迫综合征(acute respiratory distress syndrome, ARDS)患者不同的临床表现。

这是一项回顾性的病例对照研究,研究人员比较了两组分别感染COVID-19 (n=73)和H1N1 (n=75)的ARDS患者,并分析比较了他们的临床表现、影像学特点、治疗方法和预后。

COVID-19患者的中位年龄高于H1N1患者,且COVID-19患者中男性比例较高(p<0.05)。COVID-19患者无痰干咳、疲劳和胃肠道症状所占比例高于H1N1患者(p<0.05)。H1N1患者的序贯器官衰竭估计评分(SOFA)评分高于COVID-19患者(p<0.05)。COVID-19患者的PaO2/FiO2 (1980.2 mmHg)明显高于H1N1患者的PaO2/FiO2 (107.0 mmHg) (p<0.001)。与H1N1患者相比,COVID-19患者CT上毛玻璃样混浊更常见(p<0.001)。与H1N1患者相比,COVID-19患者有更多种类的抗病毒治疗。COVID-19患者的住院死亡率为28.8%,而H1N1患者的住院死亡率为34.7% (p=0.483)。SOFA评分调整后的死亡率H1N1患者明显高于COVID-19患者,其比率为2.009 (95%CI为[1.563, 2.583],p<0.001)。

由此可见,COVID-19与H1N1所致的ARDS在临床表现上存在诸多差异。与H1N1相比,COVID-19所致的ARDS患者在就诊时的疾病严重程度评分较低,经SOFA评分调整的死亡率较低。

原始出处:

Xiao Tang,et al.Comparison of Hospitalized Patients with Acute Respiratory Distress Syndrome Caused by COVID-19 and H1N1.chest.2020.https://journal.chestnet.org/article/S0012-3692(20)30558-4/fulltext

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1053069, encodeId=36981053069c4, content=<a href='/topic/show?id=b0082e3590' target=_blank style='color:#2F92EE;'>#ARDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2735, encryptionId=b0082e3590, topicName=ARDS)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Sep 19 18:46:41 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051540, encodeId=b3e42051540aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Sep 06 15:27:32 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929624, encodeId=6e29192962441, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Fri Apr 17 06:27:32 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431801, encodeId=cf7b14318017a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469536, encodeId=d0411469536fc, content=<a href='/topic/show?id=d46a83e3d8' target=_blank style='color:#2F92EE;'>#H1N1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8373, encryptionId=d46a83e3d8, topicName=H1N1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ee77038498, createdName=TZF0806, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582269, encodeId=f7f5158226961, content=<a href='/topic/show?id=e46f396832b' target=_blank style='color:#2F92EE;'>#呼吸窘迫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39683, encryptionId=e46f396832b, topicName=呼吸窘迫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22be16898890, createdName=12498cf9m40(暂无昵称), createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=)]
    2021-09-19 病毒猎手
  2. [GetPortalCommentsPageByObjectIdResponse(id=1053069, encodeId=36981053069c4, content=<a href='/topic/show?id=b0082e3590' target=_blank style='color:#2F92EE;'>#ARDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2735, encryptionId=b0082e3590, topicName=ARDS)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Sep 19 18:46:41 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051540, encodeId=b3e42051540aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Sep 06 15:27:32 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929624, encodeId=6e29192962441, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Fri Apr 17 06:27:32 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431801, encodeId=cf7b14318017a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469536, encodeId=d0411469536fc, content=<a href='/topic/show?id=d46a83e3d8' target=_blank style='color:#2F92EE;'>#H1N1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8373, encryptionId=d46a83e3d8, topicName=H1N1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ee77038498, createdName=TZF0806, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582269, encodeId=f7f5158226961, content=<a href='/topic/show?id=e46f396832b' target=_blank style='color:#2F92EE;'>#呼吸窘迫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39683, encryptionId=e46f396832b, topicName=呼吸窘迫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22be16898890, createdName=12498cf9m40(暂无昵称), createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1053069, encodeId=36981053069c4, content=<a href='/topic/show?id=b0082e3590' target=_blank style='color:#2F92EE;'>#ARDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2735, encryptionId=b0082e3590, topicName=ARDS)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Sep 19 18:46:41 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051540, encodeId=b3e42051540aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Sep 06 15:27:32 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929624, encodeId=6e29192962441, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Fri Apr 17 06:27:32 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431801, encodeId=cf7b14318017a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469536, encodeId=d0411469536fc, content=<a href='/topic/show?id=d46a83e3d8' target=_blank style='color:#2F92EE;'>#H1N1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8373, encryptionId=d46a83e3d8, topicName=H1N1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ee77038498, createdName=TZF0806, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582269, encodeId=f7f5158226961, content=<a href='/topic/show?id=e46f396832b' target=_blank style='color:#2F92EE;'>#呼吸窘迫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39683, encryptionId=e46f396832b, topicName=呼吸窘迫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22be16898890, createdName=12498cf9m40(暂无昵称), createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=)]
    2020-04-17 Smile2680
  4. [GetPortalCommentsPageByObjectIdResponse(id=1053069, encodeId=36981053069c4, content=<a href='/topic/show?id=b0082e3590' target=_blank style='color:#2F92EE;'>#ARDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2735, encryptionId=b0082e3590, topicName=ARDS)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Sep 19 18:46:41 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051540, encodeId=b3e42051540aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Sep 06 15:27:32 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929624, encodeId=6e29192962441, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Fri Apr 17 06:27:32 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431801, encodeId=cf7b14318017a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469536, encodeId=d0411469536fc, content=<a href='/topic/show?id=d46a83e3d8' target=_blank style='color:#2F92EE;'>#H1N1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8373, encryptionId=d46a83e3d8, topicName=H1N1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ee77038498, createdName=TZF0806, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582269, encodeId=f7f5158226961, content=<a href='/topic/show?id=e46f396832b' target=_blank style='color:#2F92EE;'>#呼吸窘迫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39683, encryptionId=e46f396832b, topicName=呼吸窘迫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22be16898890, createdName=12498cf9m40(暂无昵称), createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1053069, encodeId=36981053069c4, content=<a href='/topic/show?id=b0082e3590' target=_blank style='color:#2F92EE;'>#ARDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2735, encryptionId=b0082e3590, topicName=ARDS)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Sep 19 18:46:41 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051540, encodeId=b3e42051540aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Sep 06 15:27:32 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929624, encodeId=6e29192962441, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Fri Apr 17 06:27:32 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431801, encodeId=cf7b14318017a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469536, encodeId=d0411469536fc, content=<a href='/topic/show?id=d46a83e3d8' target=_blank style='color:#2F92EE;'>#H1N1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8373, encryptionId=d46a83e3d8, topicName=H1N1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ee77038498, createdName=TZF0806, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582269, encodeId=f7f5158226961, content=<a href='/topic/show?id=e46f396832b' target=_blank style='color:#2F92EE;'>#呼吸窘迫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39683, encryptionId=e46f396832b, topicName=呼吸窘迫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22be16898890, createdName=12498cf9m40(暂无昵称), createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=)]
    2020-03-30 TZF0806
  6. [GetPortalCommentsPageByObjectIdResponse(id=1053069, encodeId=36981053069c4, content=<a href='/topic/show?id=b0082e3590' target=_blank style='color:#2F92EE;'>#ARDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2735, encryptionId=b0082e3590, topicName=ARDS)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Sep 19 18:46:41 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051540, encodeId=b3e42051540aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Sep 06 15:27:32 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929624, encodeId=6e29192962441, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Fri Apr 17 06:27:32 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431801, encodeId=cf7b14318017a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469536, encodeId=d0411469536fc, content=<a href='/topic/show?id=d46a83e3d8' target=_blank style='color:#2F92EE;'>#H1N1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8373, encryptionId=d46a83e3d8, topicName=H1N1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ee77038498, createdName=TZF0806, createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582269, encodeId=f7f5158226961, content=<a href='/topic/show?id=e46f396832b' target=_blank style='color:#2F92EE;'>#呼吸窘迫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39683, encryptionId=e46f396832b, topicName=呼吸窘迫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22be16898890, createdName=12498cf9m40(暂无昵称), createdTime=Mon Mar 30 03:27:32 CST 2020, time=2020-03-30, status=1, ipAttribution=)]

相关资讯

Small:新型广谱抗流感病毒黏膜纳米疫苗

日前,全球多地流感肆虐,死亡人数持续攀升,防控形势严峻。接种疫苗是预防流感最有效的途径。但流感病毒有多种亚型,变异快,现有灭活疫苗需要针对流行毒株变化每年更新。开发广谱性流感疫苗对流感病毒防治具有重要意义。近期,中国科学院武汉病毒研究所研究员崔宗强与副研究员陈建军合作,成功研制了一种新型广谱性抗流感病毒黏膜纳米疫苗。

Int J Nanomed:金刚烷胺官能化硒纳米颗粒可抑制H1N1流感病毒诱导的细胞凋亡

作为治疗性抗病毒药物,金刚烷胺(AM)的临床应用受限于耐药病毒的出现。为了克服耐药病毒并满足日益增长的临床诊断需求,亟需开发新型抗流感药物,越来越多的研究人员使用生物纳米颗粒(NPs)开发新型抗流感药物。硒纳米粒子的低毒性和优异活性的抗病毒活性使得其在生物医学中的应用变得越来越广泛。 在本研究中,研究人员通过AM修饰硒纳米粒子表面(Se@AM)旨在逆转由流感病毒感染引起的耐药性。结果显示,毒

Crit Care:血浆代谢组学对H1N1流感肺炎的诊断和预后如何?

这项研究的结果表明,H1N1肺炎可以产生一个相当不同的血浆代谢谱,并且使其在病程早期基于入院24小时内的血浆样本,将其从细菌培养阳性肺炎和ICU中机械通气的对照者中进行区分出来。

紧急!安徽已确诊5名H1N1甲流重症患者,专家正全力救治!市卫计委说...

1月24日至今亳州市人民医院共收治5例重症肺炎患者经该市疾控中心核酸检测确诊为H1N1甲型流感属丙类传染病。

“广谱”流感疫苗动物实验成功

美国佐治亚大学29日报告说,该校研究人员与法国赛诺菲巴斯德公司合作,开发出了一种对多种毒株的甲型H1N1流感病毒都具有防护作用的流感疫苗,在实验鼠身上显示可以提供有效防护。 甲型H1N1流感病毒最初被称为“猪流感”。目前这种新型流感已经成为季节性流感。疫苗开发小组在最新一期美国《病毒学杂志》上介绍说,他们分析了多种流感病毒毒株的基因序列,利用名为“计算优化广泛反应抗原(COBRA)”的技术

ANN RHEUM DIS:干燥综合征H1N1疫苗接种引起多克隆B细胞活化并促进自身抗体产生

这篇关于自身免疫患者对外源性刺激免疫反应的综合分析确定了干燥综合征B细胞活化的机制基础。