ARCH PATHOL LAB MED:低放大倍数下精细组织学特征的估计如何?

2018-11-15 MedSci MedSci原创

全幻灯片成像开创了一个新的技术时代,促进了计算图像分析在诊断中的应用,并且已经开始将分析幻灯片的功能转移到计算机监视器上。由于全幻灯片图像中包含可用的大量细节,分析程序-无论是计算还是视觉,通常在低于获取图像的放大率的放大倍数下操作。结果,图像分辨率相应会降低。目前还不清楚当放大倍数减少时会丢失多少信息,以及组织切片的丰富颜色属性是否有助于重建某些信息。本研究旨在分析整个幻灯片图像的颜色和空间属性

全幻灯片成像开创了一个新的技术时代,促进了计算图像分析在诊断中的应用,并且已经开始将分析幻灯片的功能转移到计算机监视器上。由于全幻灯片图像中包含可用的大量细节,分析程序-无论是计算还是视觉,通常在低于获取图像的放大率的放大倍数下操作。结果,图像分辨率相应会降低。目前还不清楚当放大倍数减少时会丢失多少信息,以及组织切片的丰富颜色属性是否有助于重建某些信息。本研究旨在分析整个幻灯片图像的颜色和空间属性之间的对应关系,以阐明分辨率降低对载玻片组织学属性的影响。
研究人员模拟图像分辨率降低并模拟其对基础组织结构分类的影响。通过利用测量的组织学特征和组织结构之间的内在空间关系,开发了一种预测模型,以超过图像分辨率的方式估计组织的组织结构组成。
研究表明,在放大倍数低于×10时,分辨率降低导致严重丧失了准确描述组织学成分的能力。通过利用像素颜色,这种能力在所有放大倍数下得到改善。组织学图像的多尺度分析需要充分了解图像分辨率所带来的限制。研究结果表明,计算建模可以克服其中一些限制。

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    2019-01-31 yb6560
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    2018-11-17 hb2008ye
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    2018-11-16 1dd8a7c5m95(暂无匿称)

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0