Hypertension:中年房颤患者血压控制与痴呆风险

2020-03-16 MedSci原创 MedSci原创

由此可见,在中年房颤患者中,血压与痴呆风险呈u型相关,而高血压负荷与痴呆风险呈对数线性相关。减轻房颤患者的高血压负担可能有助于预防痴呆。

即使没有明显的卒中,房颤也会增加认知障碍和痴呆的风险。高血压已成为痴呆的潜在可改变的危险因素,尤其在中年(<70岁)人群中。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在探究中年房颤患者血压(BP)和高血压负担与痴呆风险之间的关系。从韩国国民健康保险服务数据库中,研究人员招募了17228例年龄在50到69岁之间的无痴呆AF患者。

在平均6.6年的随访中,9909名患者首次被诊断为痴呆症。收缩压和舒张压与痴呆风险之间呈u型关系:收缩压从120mmHg开始升高或降低10mmHg分别与痴呆风险升高4.4% (95%CI为2.7%-6.0%)和4.6% (95%CI为0.1%-8.2%)有关。舒张压从80mmHg开始升高或降低也会增加痴呆的风险。在亚型分析中,阿尔茨海默病随血压降低而升高,血管性痴呆随血压升高而升高。当在时间更新模型中考虑血压随时间的变化时,血压在120至129/80至84mmHg之间的痴呆风险最低。增加的高血压负担(随访期间血压升高天数的比例)与更高的痴呆风险相关(每增加10%的风险比为1.10[95%CI为1.08-1.12])。

由此可见,在中年房颤患者中,血压与痴呆风险呈u型相关,而高血压负荷与痴呆风险呈对数线性相关。减轻房颤患者的高血压负担可能有助于预防痴呆。

原始出处:

Daehoon Kim.et al.Blood Pressure Control and Dementia Risk in Midlife Patients With Atrial Fibrillation.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14388

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    2020-07-10 feather89
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    2020-03-17 MYcat124

    戒烟刻不容缓

    0

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    2020-03-16 心介

    房颤,临床上碰到很多哦

    0

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    2020-03-16 junJUN

    老年人痴呆何药可用??

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