Dev Cell:科学家找到彻底消灭癌细胞的“新武器”

2017-06-20 Heather_z727 来宝网

最新研究详细阐述了,死亡细胞如何被取代,如何利用微生物杀死癌细胞,基于这一发现,研究人员找到减少癌变肿瘤的新方法。



研究揭示微生物如何消灭癌细胞】最新研究详细阐述了,死亡细胞如何被取代,如何利用微生物杀死癌细胞,基于这一发现,研究人员找到减少癌变肿瘤的新方法。

研究人员表示“我相信我们的此次研究对于癌症生物学和抗癌药物的开发都是至关重要的,多年来,我们始终致力于研究铜绿假单胞菌,这是一种可以致命的细菌,因为这种细菌可以分泌一些引起感染的毒素ExoT,所分泌的毒素抑制细胞分裂,阻碍伤口愈合,但是同时也可以杀死癌细胞。

研究人员找出了ExoT解锁时的机制,发现竟与癌症机制是完全相同的,这是一个偶然的情况吗?在将近20年的研究中,研究人员始终试图厘清细胞的正常生命周期以及死亡的过程。

研究人员发现,闪亮的铜绿假单胞菌的致命性实际上是“补偿性增殖信号”(CPS)的过程。

在观察CPS的过程中,研究人员发现死亡细胞释放包含CRKL蛋白质的“微泡”,前往邻近的细胞,使它们接触创造取代死亡细胞的新细胞。

细胞凋亡是细胞周期的一部分,人类每秒钟大约有一百万细胞死亡,细胞凋亡并不是唯一类型的细胞死亡,在此期间,基因或ExoT毒素可以阻止细胞代偿增生冷,这是铜绿假单胞菌利用受损组织完成的过程,这也为疾病的提供了可能性。

原始出处:

Kajal H. Gupta, Josef W. Goldufsky, Stephen J. Wood, et al. Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles. Developmental Cell, 2017. Vol. 41, Issue 6, p674–684.e5.

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    2018-01-06 维他命
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    2017-07-10 fzwish20000
  4. 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encodeId=7946213298cc, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Wed Jun 21 03:37:52 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-06-22 yxch36
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encodeId=7946213298cc, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Wed Jun 21 03:37:52 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-06-21 fztmed

    好文,不知理论与实践及临床应用的距离会有多久

    0

  6. 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encodeId=7946213298cc, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Wed Jun 21 03:37:52 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-06-21 honghongwuwu

    好文章,学习了

    0

  7. 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encodeId=7946213298cc, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Wed Jun 21 03:37:52 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-06-21 日月生辉

    新机理,学习了

    0

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encodeId=7946213298cc, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Wed Jun 21 03:37:52 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-06-21 Julie W

    要理论联系实际,学习了,感谢分享

    0

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encodeId=7946213298cc, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Wed Jun 21 03:37:52 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-06-21 1e0d2fb7m34(暂无匿称)

    理论距离实践还是有遥远的距离的

    0

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