Obstet Gynecol:卵巢静脉血栓患者复发性静脉血栓栓塞的发生率和生存率如何?

2017-10-22 xing.T MedSci原创

卵巢静脉血栓形成是一种罕见的血栓性疾病,与下肢DVT相比,发病率要低60倍。癌症与卵巢静脉血栓形成患者的总生存率呈显著的相关性,并对其产生不利影响。静脉血栓栓塞复发率与直接口服抗凝剂或维生素K拮抗剂抗凝有关,尤其是既往有静脉血栓栓塞史者。

近日,妇产科权威杂志Obstetrics and Gynecology上发表了一篇研究文章,研究人员旨在明确卵巢静脉血栓患者静脉血栓栓塞复发、大出血和死亡的风险,以便更好地确定最佳的治疗策略。

研究人员对卵巢静脉血栓形成患者(1990年-2015年)和年龄以及性别匹配的下肢深静脉血栓(DVT)患者进行了病例对照研究,评估了病因、静脉血栓栓塞复发和生存率的差异。

在该研究期间,有219例卵巢静脉血栓病例和13417例下肢DVT患者被纳入研究。随访时间的中位数为1.23年(四分位间距为0.25-4.14)。卵巢静脉血栓患者发生肺栓塞为6%,DVT患者发生肺栓塞的为16%(P=001)。卵巢静脉血栓形成的常见原因包括癌症、激素刺激、手术和住院。卵巢静脉血栓患者中癌症发生率加倍(44% vs. 21%,P<01)。尽管抗凝治疗后发生率较少(卵巢静脉血栓形成为54% vs. DVT为98%,P<001),静脉血栓栓塞复发率组间相似(卵巢静脉血栓形成为2.3 vs. DVT为1.8例每100人,P=0.49)。静脉血栓栓塞病和既往手术的疾病史被认为是接受抗凝治疗患者发生静脉血栓栓塞复发的独立危险因素(分别有风险比为6.7,P=0.04和风险比为13.6,P=0.03)。这些患者的总生存率无显著差异。

由此可见,卵巢静脉血栓形成是一种罕见的血栓性疾病,与下肢DVT相比,发病率要低60倍。癌症与卵巢静脉血栓形成患者的总生存率呈显著的相关性,并对其产生不利影响。静脉血栓栓塞复发率与直接口服抗凝剂或维生素K拮抗剂抗凝有关,尤其是既往有静脉血栓栓塞史者。

原始出处:

Lenz, Charles J, et al. Ovarian Vein Thrombosis: Incidence of Recurrent Venous Thromboembolism and Survival.Obstetrics & Gynecology.2017. http://journals.lww.com/greenjournal/Abstract/publishahead/Ovarian_Vein_Thrombosis__Incidence_of_Recurrent.98250.aspx

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    2018-05-01 xue8602
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2044014, encodeId=916e20440149a, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Wed Jul 04 18:19:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037992, encodeId=2e58203e99278, content=<a href='/topic/show?id=3b364256225' target=_blank style='color:#2F92EE;'>#复发性静脉血栓栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42562, encryptionId=3b364256225, topicName=复发性静脉血栓栓塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33b92500139, createdName=12498b37m72暂无昵称, createdTime=Sun Mar 04 20:19:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826385, encodeId=74b0182638548, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Oct 04 18:19:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955317, encodeId=808b195531e54, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue May 01 17:19:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909672, encodeId=3e0f19096e294, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sat May 12 11:19:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697555, encodeId=af99169e55542, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Mon Jul 02 05:19:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011344, encodeId=b1422011344ff, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Sun Aug 05 07:19:00 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256604, encodeId=bb23125660477, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Tue Oct 24 06:19:00 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255119, encodeId=c2b4255119a7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sun Oct 22 16:06:44 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
    2018-07-02 fusion
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    2018-08-05 yhy100200
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  9. [GetPortalCommentsPageByObjectIdResponse(id=2044014, encodeId=916e20440149a, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Wed Jul 04 18:19:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037992, encodeId=2e58203e99278, content=<a href='/topic/show?id=3b364256225' target=_blank style='color:#2F92EE;'>#复发性静脉血栓栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42562, encryptionId=3b364256225, topicName=复发性静脉血栓栓塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33b92500139, createdName=12498b37m72暂无昵称, createdTime=Sun Mar 04 20:19:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826385, encodeId=74b0182638548, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Oct 04 18:19:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955317, encodeId=808b195531e54, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue May 01 17:19:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909672, encodeId=3e0f19096e294, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sat May 12 11:19:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697555, encodeId=af99169e55542, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Mon Jul 02 05:19:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011344, encodeId=b1422011344ff, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Sun Aug 05 07:19:00 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256604, encodeId=bb23125660477, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Tue Oct 24 06:19:00 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255119, encodeId=c2b4255119a7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sun Oct 22 16:06:44 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
    2017-10-22 衣带渐宽

    学习

    0