JACC:低水平耳屏刺激治疗ST段抬高心梗的缺血-再灌注损伤

2017-08-21 xiangting MedSci原创

LL-TS降低STEMI患者的心肌缺血再灌注损伤。

这项研究的目的是探讨低水平耳屏刺激(LL-TS)治疗是否可以减轻ST段抬高型心肌梗死(STEMI)患者的心肌缺血-再灌注损伤。此前已有研究表明,LL-TS可以减少由缺血引发的心肌损伤的大小。

症状发作12小时内的STEMI患者接受经皮冠脉介入治疗,被随机分为LL-TS组(n = 47)或对照组(假刺激[n = 48])。患者到达导管室即以比减慢窦速率的电流强度低50%的LL-TS刺激右侧耳屏,并在球囊扩张(再灌注)后持续2小时)。所有患者均随访7天。评估再灌注相关性心律失常,CK-MB、肌红蛋白、N-末端前B型利尿钠肽和炎症标志物的血液水平以及超声心动图特征。

LL-TS的前24 h的再灌注相关性室性心律失常的发生率明显降低。此外,LL-TS组CK-MB和肌红蛋白72小时的曲线下面积显著小于对照组。并且,LL-TS组炎症标志物血液水平降低。LL-TS显著改善由N末端前B型利尿钠肽水平代表的心功能,左心室射血分数和壁运动指数均显著改善。

LL-TS降低STEMI患者的心肌缺血-再灌注损伤。这项研究说明这种非侵入性的策略可能会被应用于PCI治疗的STEMI患者。

原始出处:

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    2018-03-10 hbwxf
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    2017-08-23 gdsun
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    2017-08-23 hyf035
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    2017-08-21 天涯183

    非常好的文章,学习了,很受益

    0

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