Stroke:缺血性脑卒中患者偏头痛与脑血管动脉粥样硬化有啥关系?

2017-05-21 xing.T MedSci原创

由此可见,偏头痛与急性缺血性卒中患者大血管过度动脉粥样硬化无关。该研究的结果表明偏头痛导致的缺血性卒中的生物学机制与脑内大血管动脉粥样硬化无关。

偏头痛是缺血性卒中的一个已知的危险因素,但偏头痛也与其他血管疾病有关。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,该研究旨在探讨急性缺血性卒中患者偏头痛与脑血管动脉粥样硬化之间的相关性。

研究人员检索了荷兰急性中风研究(DUST)中缺血性卒中患者的数据。研究人员采用偏头痛筛查器评估了偏头痛病史,并根据ICHD(头痛疾病国际分类)标准经过电话采访来予以证实。研究人员评估了颅内和颅外动脉粥样硬化性变化,并且量化颈内动脉颅钙化水平,以作为非增强CT和CT血管造影的动脉粥样硬化负担指标。研究人员采用调整了可能混杂因素的多元泊松回归分析计算了风险比。

该研究共纳入656例患者,年龄为18-99岁,其中53例有偏头痛病史(29例有先兆)。偏头痛患者没有更频繁的颅内动脉(51% vs. 74%;调整后的风险比为0.82;95%可信区间为0.64-1.05)或颅外血管(62% vs. 79%;调整后的风险比为0.93;95%可信区间为0.77-1.12)粥样硬化改变,相比于没有偏头痛的患者,并且有相当的颈内动脉钙化体积(最大 vs. 中间以及最小体积三分位数分别为23%和35%;调整后的风险比为0.93;95%可信区间为0.57-1.52)。

由此可见,偏头痛与急性缺血性卒中患者大血管过度动脉粥样硬化无关。该研究的结果表明偏头痛导致的缺血性卒中的生物学机制与脑内大血管动脉粥样硬化无关。

原始出处:

Hendrikus J.A. van Os, et al. Migraine and Cerebrovascular Atherosclerosis in Patients With Ischemic Stroke.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.116.016133

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    2017-06-11 jyzxjiangqin

    缺血性脑卒中患者的治疗。

    0

  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201094, encodeId=a5bf20109418, content=缺血性脑卒中患者的治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon May 22 07:28:29 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201077, encodeId=8d4f2010e793, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon May 22 07:07:33 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201061, encodeId=68ca201061f2, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Mon May 22 06:31:59 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-22 大爰

    学习了谢谢分享!!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1892871, encodeId=fa0118928e153, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Nov 26 09:04:00 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720175, encodeId=c1ee1e20175d2, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=209225, encodeId=e64220922508, content=缺血性脑卒中患者的治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Jun 11 07:24:09 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201104, encodeId=bf762011040d, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon May 22 07:35:38 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201094, encodeId=a5bf20109418, content=缺血性脑卒中患者的治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon May 22 07:28:29 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201077, encodeId=8d4f2010e793, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon May 22 07:07:33 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201061, encodeId=68ca201061f2, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Mon May 22 06:31:59 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-22 jyzxjiangqin

    缺血性脑卒中患者的治疗。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1892871, encodeId=fa0118928e153, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Nov 26 09:04:00 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720175, encodeId=c1ee1e20175d2, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, 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May 22 07:07:33 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201061, encodeId=68ca201061f2, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Mon May 22 06:31:59 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-22 tanxingdoctor

    学习啦谢谢分享

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201094, encodeId=a5bf20109418, content=缺血性脑卒中患者的治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon May 22 07:28:29 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201077, encodeId=8d4f2010e793, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon May 22 07:07:33 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201061, encodeId=68ca201061f2, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Mon May 22 06:31:59 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-22 meiliwuxian

    厉害

    0

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Diabetes Care:甘油三酯和HDL-C血脂异常与冠心病和缺血性脑卒中风险分析!

高TG水平和低HDL水平成人,尤其是那些有糖尿病患者,其发生CHD和脑卒中风险增加。特别是,那些LDL-C水平≥130mg/dL的参与者可能发生脑卒中的风险增加。

Stroke:缺血性脑卒中患者缺血性病变体积与功能预后之间的关系!

由此可见,在脑卒中发病后24小时内ILV增长是很常见的。然而,24小时ILV证明是有价值的次要结局指标,它与发病后1周的ILV与功能预后之间的相关性一样强烈。

Nature Medicine:预防缺血性脑卒中后过度炎症的新机制!

研究人员的发现揭示了损伤相关分子模式清除的细胞机制,从而解决了组织损伤引发的无菌性炎症反应。

你必须了解的缺血性脑卒中相关研究进展

缺血性脑卒中是指由于脑的供血动脉(颈动脉和椎动脉)狭窄或闭塞、脑供血不足导致的脑组织坏死的总称。有四种类型的脑缺血:短暂性脑缺血发作(TIA);可逆性神经功能障碍(RIND);进展性卒中(SIE);完全性卒中(CS)。TIA无脑梗死存在,而RIND、SIE和CS有不同程度的脑梗死存在。本文小编就缺血性脑卒中相关研究进展进行汇总,与大家一起学习进步。【1】Stroke:胰岛素抵抗与非糖尿病的缺血

Stroke:胰岛素抵抗与非糖尿病的缺血性脑卒中患者预后相关吗?

由此可见,在非糖尿病的急性缺血性脑卒中患者中,胰岛素抵抗与死亡、卒中复发以及较差的预后风险增加相关,但与依赖性无关。