Hepatology:美国男性和女性的饮食模式和肝细胞癌的风险

2018-12-30 万敏婕, 高普均 临床肝胆病杂志

虽然根据指南保持健康饮食与降低心血管疾病、2型糖尿病和某些癌症风险相关,但对饮食模式在肝细胞癌发展中的作用知之甚少。

虽然根据指南保持健康饮食与降低血管疾病、2型糖尿病和某些癌症风险相关,但对饮食模式在肝细胞癌发展中的作用知之甚少。

在卫生专业人员的随访研究(HPFS)和护理健康研究(NHS)2项大型前瞻性研究中,我们评估了3种常用的饮食模式:替代饮食健康指数-2010(AHEI-2010)、地中海饮食替代评分(AMED)和高血压防治计划饮食评分(DASH)与肝细胞癌发生风险的关系。每4年使用经过验证的食物频率问卷对饮食进行评估。使用Cox比例风险回归模型计算多变量风险比(HRs)和95%置信区间(95%CI)。

长达32年的随访期间,确诊160例肝细胞癌。在对大多数肝癌危险因素进行调整后,AHEI-2010中最高三分位组与最低三分位组相比,多变量风险比HR为0.61(95% CI: 0.39~0.95, Ptrend=0.03)。AMED(HR=0.75, 95%CI: 0.49~1.15, Ptrend=0.18)与肝细胞癌发生风险有提示性但无显着性负相关,DASH(HR= 0.90, 95% CI: 0.59~1.36, Ptrend=0.61)与肝细胞癌发生风险无相关性。

研究表明,在美国成人中,根据替代饮食健康指数-2010指导饮食或许可以降低肝细胞癌发生风险。未来的研究需要验证我们的结果,检验在其他人群中是否存在这种相关性,并阐明其潜在的机制。

原始出处:Yanan Ma Wanshui Yang Tracey G. Simon, et al. Dietary patterns and risk of hepatocellular carcinoma among US men and women. Hepatology. 01 December 2018.

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    2019-05-30 xjy02
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    2018-12-31 gwc384
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encryptionId=388a10124247, topicName=饮食模式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28de10689201, createdName=ms6519009802973839, createdTime=Mon Dec 31 16:47:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356740, encodeId=c805356e4036, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sun Dec 30 08:55:27 CST 2018, time=2018-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356738, encodeId=126e356e3818, content=中国和美国饮食习惯很不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, 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level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 30 08:26:53 CST 2018, time=2018-12-30, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1863416, encodeId=065e18634160e, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu May 30 18:47:00 CST 2019, time=2019-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978788, encodeId=f01d19e878809, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 30 08:27:03 CST 2018, time=2018-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356735, encodeId=6ac3356e3529, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 30 08:26:58 CST 2018, time=2018-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356734, encodeId=7901356e341f, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 30 08:26:53 CST 2018, time=2018-12-30, status=1, ipAttribution=)]
    2018-12-30 kafei

    了解一下谢谢

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 30 08:27:03 CST 2018, time=2018-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356735, encodeId=6ac3356e3529, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 30 08:26:58 CST 2018, time=2018-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356734, encodeId=7901356e341f, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 30 08:26:53 CST 2018, time=2018-12-30, status=1, ipAttribution=)]
    2018-12-30 flysky120

    中国和美国饮食习惯很不同

    0

  7. 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    2018-12-30 Y—xianghai

    学习了新知识

    0

  8. 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    2018-12-30 Y—xianghai

    学习了长知识

    0

  9. 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    2018-12-30 Y—xianghai

    学习了新知识

    0

  10. 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    2018-12-30 Y—xianghai

    学习了长知识

    0

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