Sci Rep:检测类风湿性关节炎或骨关节炎患者培养阴性滑膜组织和液体样本中的细菌核酸

2018-09-25 xiangting MedSci原创

总的来说,该研究证实了RA和OA病变的SF和ST样本中存在细菌核酸,并揭示了与疾病程度的潜在相关性。

人体肠道微生物可以介导关节炎的发展。尽管其潜在机制尚不清楚,有研究表明某些细菌核酸可能存在于滑膜液(SF)中并参与关节炎。

为了表征潜在的SF细菌核酸,对来自125名类风湿性关节炎(RA)患者的15个滑膜组织(ST)和110个SF样本、以及58名骨关节炎(OA)患者的16个ST和42个SF样本,研究人员使用16S rRNA基因扩增子测序来评估中的细菌核酸群落。

研究结果显示这些临床样本中的细菌核酸多样性丰富,所有183个样本中均存在卟啉单胞菌和拟杆菌。类风湿性关节炎(STRA)滑膜组织中的农杆菌属、丛毛平胞菌属、考克氏菌属、亚栖热菌属和红游动菌属更为丰富。奇异菌属、考拉杆菌属、胶红酵母、单形拟杆菌、罗思氏菌属、巨球形菌属、苏黎世杆菌科、纤毛菌属、副流感嗜血杆菌、脆弱拟杆菌、卟啉单胞菌和链球菌属在骨关节炎滑膜组织(STOA)中更丰富。两异韦荣球菌、副流感嗜血杆菌、普氏菌和密螺旋体属在类风湿性关节炎的滑膜液中(SFRA)更为丰富,而粪拟杆菌在骨关节炎的滑膜液中(SFOA)更为丰富。

总的来说,该研究证实了RA和OA病变的SF和ST样本中存在细菌核酸,并揭示了与疾病程度的潜在相关性。

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    2018-12-02 lisa438
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    2019-09-05 zhzhxiang
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    2018-09-27 lmm397
  5. [GetPortalCommentsPageByObjectIdResponse(id=2026587, encodeId=8f23202658ef1, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sun Dec 02 07:43:00 CST 2018, time=2018-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669393, encodeId=835b1669393b5, content=<a href='/topic/show?id=9d7b620395d' target=_blank style='color:#2F92EE;'>#样本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62039, encryptionId=9d7b620395d, topicName=样本)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f33226554040, createdName=zhzhxiang, createdTime=Thu Sep 05 11:43:00 CST 2019, time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805434, encodeId=1e8f1805434e2, content=<a href='/topic/show?id=63dee81108d' target=_blank style='color:#2F92EE;'>#细菌核酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78110, encryptionId=63dee81108d, topicName=细菌核酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Wed Apr 17 00:43:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265804, encodeId=f79212658049e, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Sep 27 01:43:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334073, encodeId=f27f13340e321, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Sep 27 01:43:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483547, encodeId=4e5c148354e6e, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Thu Sep 27 01:43:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346558, encodeId=cab334655882, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Sep 25 12:00:33 CST 2018, time=2018-09-25, status=1, ipAttribution=)]
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    2018-09-25 kafei

    了解一下谢谢

    0

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