Am J Psychiatry:ADHD药物与药物相关障碍之间的关系

2017-07-15 MedSci MedSci原创

药物使用障碍是导致注意缺陷多动障碍(ADHD)患者过度死亡的主要原因,但药物ADHD治疗与药物相关问题之间的关联尚不清楚。本研究探讨ADHD药物治疗与药物相关事件之间当前和长期的关联。研究人员分析了2993887名(47.2%名女性)青少年和成人ADHD患者,来自2005 - 2014商业健康索赔。校正了混杂因素后,结果发现,与未接受ADHD药物的时间相比,接受药物治疗的男性患者药物相关事件的发生

药物使用障碍是导致注意缺陷多动障碍(ADHD)患者过度死亡的主要原因,但药物ADHD治疗与药物相关问题之间的关联尚不清楚。本研究探讨ADHD药物治疗与药物相关事件之间当前和长期的关联。

研究人员分析了2993887名(47.2%名女性)青少年和成人ADHD患者,来自2005 - 2014商业健康索赔。校正了混杂因素后,结果发现,与未接受ADHD药物的时间相比,接受药物治疗的男性患者药物相关事件的发生几率降低35%(比值比= 0.65,95% CI = 0.64-0.67),女性患者则降低31%(比值比= 0.69,95% CI = 0.67-0.71)。

此外,男性患者服药后2年的药物相关事件的发生率降低19%(比值比= 0.81,95% CI = 0.78 -0.85),女性患者则降低14%(比值比= 0.86,95% CI = 0.82-0.91)。敏感性分析支持大多数调查结果,但是女性用药后的长期效果一致性较差。

总而言之,该研究结果表明,服用ADHD药物不太可能与青少年或成年人药物相关问题发生风险增加有关。相反,ADHD与较低的药物相关事件的发生相关,至少在男性中结果如此,且未来药物相关事件的长期风险较低。

原始出处:

Patrick D. Quinn, Zheng Chang, et al., ADHD Medication and Substance-Related Problems. American Journal of Psychiatry, doi: 10.1176/appi.ajp.2017.16060686, published online 29 June 2017.

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    2018-02-13 zz70
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    2017-07-17 lg.zhao
  5. [GetPortalCommentsPageByObjectIdResponse(id=1779363, encodeId=63991e7936377, content=<a href='/topic/show?id=1a0819e9a0' target=_blank style='color:#2F92EE;'>#ADHD药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1979, encryptionId=1a0819e9a0, topicName=ADHD药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Tue Feb 13 12:32:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800623, encodeId=cf311800623c8, content=<a href='/topic/show?id=3371e2546b4' target=_blank style='color:#2F92EE;'>#相关障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72546, encryptionId=3371e2546b4, topicName=相关障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=shuangle, createdTime=Tue Dec 26 10:32:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792068, encodeId=6b131e92068b2, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Feb 05 17:32:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307600, encodeId=ba4a130e600b4, content=<a href='/topic/show?id=459f19e855' target=_blank style='color:#2F92EE;'>#ADHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1978, encryptionId=459f19e855, topicName=ADHD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Jul 17 10:32:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222692, encodeId=78082226920c, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jul 15 22:25:52 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222676, encodeId=5f912226e6d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170715/IMG596A358F8E1E86717.jpg, createdBy=91a41605601, createdName=任浩, createdTime=Sat Jul 15 21:31:43 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222663, encodeId=95dc222663cd, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Jul 15 19:49:32 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 明月清辉

    谢谢分享,学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1779363, encodeId=63991e7936377, content=<a href='/topic/show?id=1a0819e9a0' target=_blank style='color:#2F92EE;'>#ADHD药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1979, encryptionId=1a0819e9a0, topicName=ADHD药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Tue Feb 13 12:32:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800623, encodeId=cf311800623c8, content=<a href='/topic/show?id=3371e2546b4' target=_blank style='color:#2F92EE;'>#相关障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72546, encryptionId=3371e2546b4, topicName=相关障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=shuangle, createdTime=Tue Dec 26 10:32:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792068, encodeId=6b131e92068b2, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Feb 05 17:32:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307600, encodeId=ba4a130e600b4, content=<a href='/topic/show?id=459f19e855' target=_blank style='color:#2F92EE;'>#ADHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1978, encryptionId=459f19e855, topicName=ADHD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Jul 17 10:32:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222692, encodeId=78082226920c, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jul 15 22:25:52 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222676, encodeId=5f912226e6d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170715/IMG596A358F8E1E86717.jpg, createdBy=91a41605601, createdName=任浩, createdTime=Sat Jul 15 21:31:43 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222663, encodeId=95dc222663cd, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Jul 15 19:49:32 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 任浩

    学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1779363, encodeId=63991e7936377, content=<a href='/topic/show?id=1a0819e9a0' target=_blank style='color:#2F92EE;'>#ADHD药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1979, encryptionId=1a0819e9a0, topicName=ADHD药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Tue Feb 13 12:32:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800623, encodeId=cf311800623c8, content=<a href='/topic/show?id=3371e2546b4' target=_blank style='color:#2F92EE;'>#相关障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72546, encryptionId=3371e2546b4, topicName=相关障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=shuangle, createdTime=Tue Dec 26 10:32:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792068, encodeId=6b131e92068b2, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Feb 05 17:32:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307600, encodeId=ba4a130e600b4, content=<a href='/topic/show?id=459f19e855' target=_blank style='color:#2F92EE;'>#ADHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1978, encryptionId=459f19e855, topicName=ADHD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Jul 17 10:32:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222692, encodeId=78082226920c, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jul 15 22:25:52 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222676, encodeId=5f912226e6d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170715/IMG596A358F8E1E86717.jpg, createdBy=91a41605601, createdName=任浩, createdTime=Sat Jul 15 21:31:43 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222663, encodeId=95dc222663cd, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Jul 15 19:49:32 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0