Arthritis Rheumatol:代谢综合征及其组分与骨关节炎:弗雷明汉骨关节炎研究

2017-06-03 xiangting MedSci原创

根据BMI调整后,代谢综合征及其组分均与偶发OA无关联。OA和高血压之间可能存在关联,仍需要进一步研究。

以前的研究表明,代谢综合征与骨关节炎(OA)相关。然而,分析通常不包括根据体重指数(BMI)调整,并没有解决代谢综合征成分的水平是否与OA相关。这项研究旨在探讨代谢综合征及其组分与影像学和症状性膝关节OA的关系。

弗雷明汉研究对象在1992-1995年和2002-2005年期间对OA进行了评估。基线访问,对受试者进行了代谢综合征成分评估。偶发影像学OA定义为基线时膝关节没有影像OA,在随访期间Kealgren / Lawrence等级≥2。偶发症状性OA定义为膝关节出现新的影像学OA和膝盖疼痛。在基线排除膝关节以前的OA后,根据二元回归与广义估计方程的比例计算出的BMI调整的前后,测试了根据国家胆固醇教育计划成人治疗组III标准的代谢综合征及其组成部分与偶发影像学OA和症状性OA的风险之间的关系。

共研究了991例患者(55.1%女性),平均年龄54.2岁。26.7%的男性,22.9%女性患有代谢综合征。代谢综合征及其许多组分与偶发影像学OA和症状性OA相关,但在根据BMI调整后,几乎所有这些关联都变弱并且不显著。高血压,特别是舒张压与OA的关联持续存在于男性和女性中。

根据BMI调整后,代谢综合征及其组分均与偶发OA无关联。OA和高血压之间可能存在关联,仍需要进一步研究。

原始出处:
Jingbo Niu, Margaret Clancy, Piran Aliabadi,et al. Metabolic Syndrome, Its Components, and Knee Osteoarthritis: The Framingham Osteoarthritis Study. Arthritis Rheumatol. June 2017.

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    2017-10-02 lisa438
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    2017-06-05 lmm397
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    2017-06-05 zhaojie88
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