直播:秦钧:蛋白组学如何助力精准医学?

2017-10-28 佚名 生物探索

2017年10月27-28日,西安全球硬科技创新大会首场论坛——第四届中国药物基因组学学术大会暨首届中国个体化用药-精准医学科学产业联盟大会在西安曲江凯悦酒店拉开帷幕。期间,来自于军事医学科学院国家蛋白质科学中心、军事医学科学院、美国贝勒医学院的秦钧教授在此次大会上进行了“蛋白质组学和精准医学”的主题报告。

2017年10月27-28日,西安全球硬科技创新大会首场论坛——第四届中国药物基因组学学术大会暨首届中国个体化用药-精准医学科学产业联盟大会在西安曲江凯悦酒店拉开帷幕。本次大会以“药物基因组助力未来健康”为主题,吸引国内生命科学领域的多名院士、专家齐聚西安,就药物基因组学的前沿技术与产业落地进行研讨与交流。

期间,来自于军事医学科学院国家蛋白质科学中心、军事医学科学院、美国贝勒医学院的秦钧教授在此次大会上进行了“蛋白质组学和精准医学”的主题报告。

秦钧教授是世界上少数几位将质谱仪设计、蛋白质组学方法开发、生物信息学、生物学及临床应用纳入同一个研究项目的学者之一。在蛋白质复合体研究方面,建立了国际领先的蛋白质复合体纯化和鉴定方法;在蛋白质网络研究方面,建立了世界上最大的内源性人蛋白质复合体数据集;在DNA损伤修复方面,开展了大量卓有成效的研究工作。

以下为主题报告概要:

今天我分享的是蛋白质组学,共同探讨这一组学在精准医疗领域的应用机遇和挑战。

2010年,我回国参加了“凤凰工程”(PHOENIX),联合几位专家耗时7、8年建成国家蛋白质科学中心,坐落于北京中关村生命科学园。这个中心有什么特点?它是一个平台,让我们有机会尝试开拓一些先创性的东西。

我们专注于检测蛋白,开发了一套技术,让蛋白质组学研究在速度上占得优势,可以大批量实现蛋白检测。我们还有一台超级计算机,支撑我们的一站式蛋白质组学云平台,被命名为“梧桐树”。在这样一个体系下,我们每天可以完成10-20个蛋白质组分析。

我们从蛋白质表达量、翻译后修饰还有活性3个层面进行检测,并将其应用于弥散性肿瘤的诊断中。

临床上很少会有新鲜的样本,我们需要在蜡块里面测蛋白,并为肿瘤分型提供依据,指导治疗。这一技术难关现在已经解决。针对不同患者,蛋白质组学检测可以了解他们携带的标志物,从而为药物选择和剂量提供指导

最有意思的是做尿蛋白,尿液富集简单,但是尿蛋白丰度变化较大,受当日饮食、身体状态等多种因素影响。所以,尿蛋白有一个变化范围。我们需要借助大量样本,制定这一范围。

蛋白组学如何助力精准医学?这需要构建大数据,获取不同肿瘤患者的蛋白质信息,将其与表型、药物反应等数据结合,实现个性化治疗。

备注:内容根据速记整理,未经嘉宾本人审核。

大会信息:

名称:中国药物基因组学学术大会暨首届中国个体化用药-精准医学科学产业联盟大会

时间:10月27日至28日,上午9:00-12:00,下午1:45-6:00

地点:西安曲江凯悦酒店大宴会厅

主办:中共西安市委、西安市人民政府、中国药理学会药物基因组专业委员会、中国个药联盟

承办: 西北大学、国家微检测系统工程技术研究中心、陕西基因检测精准医学示范中心、陕西佰美基因股份有限公司、陕西省国际医学交流促进会、西咸新区科统办

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2038101, encodeId=b646203810175, content=<a href='/topic/show?id=82aa886807b' target=_blank style='color:#2F92EE;'>#蛋白组学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88680, encryptionId=82aa886807b, topicName=蛋白组学)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/385F510BDFE0F55A4FFDFDFFD9892943/100, createdBy=a3262500163, createdName=siiner, createdTime=Sun Oct 07 19:12:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260536, encodeId=f7bf260536c5, content=好文章大家共同分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Nov 11 13:37:13 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258355, encodeId=52d42583556c, content=非常实用.经常可以用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 03 13:48:20 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257271, encodeId=055625e2710c, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Oct 30 18:56:43 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1403232, encodeId=18b21403232d8, content=<a href='/topic/show?id=ebbde6353be' target=_blank style='color:#2F92EE;'>#精准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76353, encryptionId=ebbde6353be, topicName=精准)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epQX9hfEIBiaPg0e9KvLYVBCSGYydH6K6OQxBh3RaOC0TYP9HYy2v0XdHib1LFnZNU5Siak0P8oh8Aqw/132, createdBy=acd92440184, createdName=shijzhiewnjhch, createdTime=Mon Oct 30 03:12:00 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
    2017-11-11 虈亣靌

    好文章大家共同分享

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2038101, encodeId=b646203810175, content=<a href='/topic/show?id=82aa886807b' target=_blank style='color:#2F92EE;'>#蛋白组学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88680, encryptionId=82aa886807b, topicName=蛋白组学)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/385F510BDFE0F55A4FFDFDFFD9892943/100, createdBy=a3262500163, createdName=siiner, createdTime=Sun Oct 07 19:12:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260536, encodeId=f7bf260536c5, content=好文章大家共同分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Nov 11 13:37:13 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258355, encodeId=52d42583556c, content=非常实用.经常可以用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 03 13:48:20 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257271, encodeId=055625e2710c, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Oct 30 18:56:43 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1403232, encodeId=18b21403232d8, content=<a href='/topic/show?id=ebbde6353be' target=_blank style='color:#2F92EE;'>#精准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76353, encryptionId=ebbde6353be, topicName=精准)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epQX9hfEIBiaPg0e9KvLYVBCSGYydH6K6OQxBh3RaOC0TYP9HYy2v0XdHib1LFnZNU5Siak0P8oh8Aqw/132, createdBy=acd92440184, createdName=shijzhiewnjhch, createdTime=Mon Oct 30 03:12:00 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
    2017-11-03 虈亣靌

    非常实用.经常可以用的到

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2038101, encodeId=b646203810175, content=<a href='/topic/show?id=82aa886807b' target=_blank style='color:#2F92EE;'>#蛋白组学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88680, encryptionId=82aa886807b, topicName=蛋白组学)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/385F510BDFE0F55A4FFDFDFFD9892943/100, createdBy=a3262500163, createdName=siiner, createdTime=Sun Oct 07 19:12:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260536, encodeId=f7bf260536c5, content=好文章大家共同分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Nov 11 13:37:13 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258355, encodeId=52d42583556c, content=非常实用.经常可以用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 03 13:48:20 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257271, encodeId=055625e2710c, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Oct 30 18:56:43 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1403232, encodeId=18b21403232d8, content=<a href='/topic/show?id=ebbde6353be' target=_blank style='color:#2F92EE;'>#精准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76353, encryptionId=ebbde6353be, topicName=精准)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epQX9hfEIBiaPg0e9KvLYVBCSGYydH6K6OQxBh3RaOC0TYP9HYy2v0XdHib1LFnZNU5Siak0P8oh8Aqw/132, createdBy=acd92440184, createdName=shijzhiewnjhch, createdTime=Mon Oct 30 03:12:00 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
    2017-10-30 虈亣靌

    学习了谢谢作者分享!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2038101, encodeId=b646203810175, content=<a href='/topic/show?id=82aa886807b' target=_blank style='color:#2F92EE;'>#蛋白组学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88680, encryptionId=82aa886807b, topicName=蛋白组学)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/385F510BDFE0F55A4FFDFDFFD9892943/100, createdBy=a3262500163, createdName=siiner, createdTime=Sun Oct 07 19:12:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260536, encodeId=f7bf260536c5, content=好文章大家共同分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Nov 11 13:37:13 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258355, encodeId=52d42583556c, content=非常实用.经常可以用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 03 13:48:20 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257271, encodeId=055625e2710c, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Oct 30 18:56:43 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1403232, encodeId=18b21403232d8, content=<a href='/topic/show?id=ebbde6353be' target=_blank style='color:#2F92EE;'>#精准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76353, encryptionId=ebbde6353be, topicName=精准)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epQX9hfEIBiaPg0e9KvLYVBCSGYydH6K6OQxBh3RaOC0TYP9HYy2v0XdHib1LFnZNU5Siak0P8oh8Aqw/132, createdBy=acd92440184, createdName=shijzhiewnjhch, createdTime=Mon Oct 30 03:12:00 CST 2017, time=2017-10-30, status=1, ipAttribution=)]