J Colloid Interface Sci:混合水凝胶不仅可载药还可抗菌

2017-12-04 MedSci MedSci原创

水凝胶是一种很有应用前景的3D材料,越来越多的研究发现其可作为药物和细胞载体及递送进行应用。本研究中,我们报告了一个可注射的胶体水凝胶,直接由氧化石墨烯(GO)和热敏纳米凝胶(tNG)制备。羧基和氧乙基之间的pH依赖性氢键相互作用可使得GO和纳米凝胶之间形成可逆组装。水凝胶是可塑的,可以成型为不同的形状,随着pH和温度的变化其机械强度可调。实验研究结果显示,该混合水凝胶具有较高的抗菌活性,且作为支

水凝胶是一种很有应用前景的3D材料,越来越多的研究发现其可作为药物和细胞载体及递送进行应用。本研究中,我们报告了一个可注射的胶体水凝胶,直接由氧化石墨烯(GO)和热敏纳米凝胶(tNG)制备。

羧基和氧乙基之间的pH依赖性氢键相互作用可使得GO和纳米凝胶之间形成可逆组装。水凝胶是可塑的,可以成型为不同的形状,随着pH和温度的变化其机械强度可调。实验研究结果显示,该混合水凝胶具有较高的抗菌活性,且作为支架后具有响应药物释放行为,支架内的细胞的活性也较高。

综上所述,该研究结果表明,这种混合胶体水凝胶可以作为活性“货物”递送和细胞培养的一种很有前景的支架材料。

原始出处:

Cheng W, Chen Y, et al., Antimicrobial colloidal hydrogels assembled by graphene oxide and thermo-sensitive nanogels for cell encapsulation. J Colloid Interface Sci. 2017 Nov 8;513:314-323. doi: 10.1016/j.jcis.2017.11.018.


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    2017-12-25 waiwai3030
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    2018-11-04 shanyongle
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    2017-12-07 wangvase

    也可以用来止血?

    0

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    2017-12-06 tastas
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    2017-12-06 lishizhe
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    2017-12-04 changjiu

    学习一下谢谢

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