Eur Heart J:高血压前期和空腹血糖受损与新发房颤相关吗?

2017-07-03 xing.T MedSci原创

即使在一个无合并症的健康亚洲人群中,高血压前期和IFG是房颤的重要危险因素。具体地说,当高血压前期,包括收缩压和舒张压,最后结合IFG,新发房颤的风险尤其是在BMI低于25 kg/m2的患者中增加。

对于无合并症的健康人群,高血压前期和空腹血糖受损(IFG)的存在是否与新发房颤(AF)之间存在相关性尚不清楚。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员从2003年至2008年期间招募了366507例(年龄≥20岁)来自于韩国国民健康保险服务的国家样本队列(NHIS-NSC)的不能诊断为非瓣膜性房颤的患者。总的来说,139306例房颤相关疾病的患者被排除在外,227102名健康人群随访至2013年。在国家健康体检期间获得受试者体重指数(BMI)、血压(BP)和空腹血糖(BG)水平。

研究人员发现IFG患者[风险比(HR)为1.16,P=0.017]有较高的房颤风险,并且舒张压(HR为1.11,P=0.045)相比于收缩压是房颤发生更强的指标。将受试者分为两个相互排斥的群体后,在BMI<25 kg/m2的组中,高血压前期与IFG的组合效应显著增加房颤的发生,而在BMI≧25kg/m2 组中没有表现出这种倾向。IFG相关的房颤风险在BMI<25kg/m2的人群中更为突出(HR为1.18,P=0.025),相比于那些BMI≥25kg/m2的受试者,存在高血压前期和IFG的患者相比于没有的患者有一个更大的房颤风险(HR为1.27,P=0.016)。

即使在一个无合并症的健康亚洲人群中,高血压前期和IFG是房颤的重要危险因素。具体地说,当高血压前期,包括收缩压和舒张压,最后结合IFG,新发房颤的风险尤其是在BMI低于25 kg/m2的患者中增加。

原始出处:

Sean S. Lee,et al. Clinical implication of an impaired fasting glucose and prehypertension related to new onset atrial fibrillation in a healthy Asian population without underlying disease: a nationwide cohort study in Korea. Eur Heart J. https://doi.org/10.1093/eurheartj/ehx316

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time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218119, encodeId=2cf8218119a5, content=继续学习。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 03 12:13:59 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-10 haige

    有意义的研究!值得学习!

    0

  2. 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    2017-07-06 1e10c84am36(暂无匿称)

    文章很好,值得学习,拜读了

    0

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  4. 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time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218119, encodeId=2cf8218119a5, content=继续学习。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 03 12:13:59 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-05 zhaojie88
  5. 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  6. 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  7. 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style='color:#2F92EE;'>#高血压前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102662, encryptionId=ead91026621c, topicName=高血压前期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1448837648, createdName=kord1985, createdTime=Wed Jul 05 00:53:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562612, encodeId=a59e15626124c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Jul 05 00:53:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218153, encodeId=b39b2181536a, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Jul 03 13:51:35 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218148, encodeId=fdff218148d4, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Jul 03 13:32:19 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218119, encodeId=2cf8218119a5, content=继续学习。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 03 12:13:59 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-05 slcumt
  8. 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time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218119, encodeId=2cf8218119a5, content=继续学习。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 03 12:13:59 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-03 flysky120

    学习一下知识了

    0

  9. 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time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218119, encodeId=2cf8218119a5, content=继续学习。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 03 12:13:59 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-03 天涯183

    非常好的文章,学习了,很受益

    0

  10. 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    2017-07-03 doctorJiangchao

    继续学习。

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