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Int J Mol Med：糖尿病患者的颌骨为何容易发生骨质丧失？

2020-02-13 不详 网络

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某些microRNA（miR）在维持骨骼发育和新陈代谢中起重要作用，并且已知多种miR在糖尿病中被解除调节。本研究通过评估2型糖尿病大鼠模型的颌骨，研究了miR-203-3p在调节骨质丧失中的作用。结果表明，miR-203-3p抑制了糖尿病大鼠颌骨和高葡萄糖培养基中培养的大鼠骨髓间充质干细胞的成骨作用。萤光素酶报告法用于验证miR-203-3p靶向Smad1的3'-非翻译区的生物信息学预测，Sma

某些microRNA（miR）在维持骨骼发育和新陈代谢中起重要作用，并且已知多种miR在糖尿病中被解除调节。本研究通过评估2型糖尿病大鼠模型的颌骨，研究了miR-203-3p在调节骨质丧失中的作用。

结果表明，miR-203-3p抑制了糖尿病大鼠颌骨和高葡萄糖培养基中培养的大鼠骨髓间充质干细胞的成骨作用。萤光素酶报告法用于验证miR-203-3p靶向Smad1的3'-非翻译区的生物信息学预测，Smad1是骨形态发生蛋白（BMP）/Smad途径的重要介体。Smad1的过表达减弱了miR-203-3p介导的成骨分化抑制。因此表明，通过Smad1还原，BMP/Smad通路被减弱，而转化生长因子-β/激活素通路被激活。

两者合计，表明miR-203-3p通过靶向Smad1抑制BMP/Smad通路来抑制糖尿病大鼠颌骨的成骨作用。

原始出处：

Yuying Tang, Leilei Zheng, et al., miR-203-3p participates in the suppression of diabetes-associated osteogenesis in the jaw bone through targeting Smad1. Int J Mol Med. 2018 Mar; 41(3): 1595–1607.

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    2020-02-15 xue8604

    #糖尿病患者#

    0

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    2020-02-15 Eleven17

    #骨质#

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    2020-02-15 ms3994565386320060

    #Med#

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    2020-02-13 misszhang

    谢谢MedSci提供最新的资讯

    0