J Allergy Clin Immunol:孕期补充鱼油可影响后代过敏性呼吸系统疾病的发生?

2017-02-14 吴星 环球医学

作为营养保健品,鱼油得到了许多消费者的青睐。2017年1月,发表在《J Allergy Clin Immunol》的一项由丹麦和美国科学家进行的研究考察了孕期补充鱼油对后代过敏性呼吸系统疾病的作用。


作为营养保健品,鱼油得到了许多消费者的青睐。2017年1月,发表在《J Allergy Clin Immunol》的一项由丹麦和美国科学家进行的研究考察了孕期补充鱼油对后代过敏性呼吸系统疾病的作用。

背景:母亲补充长链n-3多不饱和脂肪酸能够通过多种抗炎途径对发育中的胎儿形成免疫影响。但是对其长期影响的了解有限。

目的:在一项从1990年开始为期24年随访的随机对照研究中,研究者旨在确定妊娠期补充长链n-3多不饱和脂肪酸2.7 g能否降低后代哮喘和过敏性呼吸系统疾病的风险。

方法:该随机对照试验纳入533例女性,按照2:1:1的比例,将这些女性随机分配至妊娠晚期使用鱼油组、橄榄油组或不使用油组。在一个强制性国家处方注册中对后代进行随访,处方的完整随访与哮喘的治疗相关,过敏性鼻炎作为主要结局。此外,邀请18至19岁的后代完成调查问卷(74%参与)并参加临床检查(47%参与)。

结果:在意向治疗分析中,与橄榄油组相比,鱼油组哮喘药物处方的概率显着降低(风险比,0.54,95% CI,0.32~0.90;P=0.02)。与橄榄油组相比,鱼油组过敏性鼻炎药物处方的概率也降低(风险比,0.70,95% CI,0.47~1.05;P=0.09),但差异不显着。后代18至19岁时的自我报告信息支持这些结果。没有监测到肺功能结局或变应性过敏的相关性。

结论:母亲补充鱼油或许对后代哮喘有潜在长期的预防作用。

原始出处:
Hansen S, Strøm M, Maslova E,et al.Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring.J Allergy Clin Immunol. 2017 Jan.

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    2017-02-18 1e216e61m01(暂无匿称)

    感觉没太大差异

    0

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    2017-02-16 膀胱癌
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