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Exp Mol Med：白藜芦醇可通过抑制RhoA/Lats1/YAP信号轴抑制乳腺癌的进展

2018-02-07 MedSci MedSci原创

关注

Hippo/YAP信通路参与了各种癌症的肿瘤发生和进展。通过抑制多个信号级联，白藜芦醇具有强的抗肿瘤和抗转移活性。 在本研究中，我们证明白藜芦醇可降低YAP靶基因的表达。此外，我们的研究结果显示，白藜芦醇通过激活Lats1并随后使YAP失活而减弱乳腺癌细胞的侵袭。尤其是，我们还发现白藜芦醇使RhoA失活，导致Lats1的激活，并诱导YAP磷酸化。此外，与单一处理相比，白藜芦醇与其他灭活Rh

Hippo/YAP信通路参与了各种癌症的肿瘤发生和进展。通过抑制多个信号级联，白藜芦醇具有强的抗肿瘤和抗转移活性。

在本研究中，我们证明白藜芦醇可降低YAP靶基因的表达。此外，我们的研究结果显示，白藜芦醇通过激活Lats1并随后使YAP失活而减弱乳腺癌细胞的侵袭。尤其是，我们还发现白藜芦醇使RhoA失活，导致Lats1的激活，并诱导YAP磷酸化。此外，与单一处理相比，白藜芦醇与其他灭活RhoA或YAP的药剂组合可更明显的抑制乳腺癌细胞的侵袭。

总的来说，这些研究结果表明，白藜芦醇可通过抑制RhoA/Lats1/YAP信号轴并随后抑制乳腺癌细胞侵袭。

原始出处：

Kim YN, Choe SR, et al., Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis. Exp Mol Med. 2017 Feb 24;49(2):e296. doi: 10.1038/emm.2016.151.

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评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2081890, encodeId=7e4e208189010, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Wed Oct 03 17:37:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987700, encodeId=3835198e7005a, content=<a href='/topic/show?id=a3d81544104' target=_blank style='color:#2F92EE;'>#RhoA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15441, encryptionId=a3d81544104, topicName=RhoA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jun 23 05:37:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068244, encodeId=fdae20682445b, content=<a href='/topic/show?id=e94b298327' target=_blank style='color:#2F92EE;'>#ATS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2983, encryptionId=e94b298327, topicName=ATS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Sun Apr 22 22:37:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006324, encodeId=f7d32006324b4, content=<a href='/topic/show?id=64782e31314' target=_blank style='color:#2F92EE;'>#信号轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27313, encryptionId=64782e31314, topicName=信号轴)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Jul 14 09:37:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608543, encodeId=c10e1608543ac, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Feb 09 10:37:00 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-10-03 gujh

    #YAP#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2081890, encodeId=7e4e208189010, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Wed Oct 03 17:37:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987700, encodeId=3835198e7005a, content=<a href='/topic/show?id=a3d81544104' target=_blank style='color:#2F92EE;'>#RhoA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15441, encryptionId=a3d81544104, topicName=RhoA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jun 23 05:37:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068244, encodeId=fdae20682445b, content=<a href='/topic/show?id=e94b298327' target=_blank style='color:#2F92EE;'>#ATS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2983, encryptionId=e94b298327, topicName=ATS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Sun Apr 22 22:37:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006324, encodeId=f7d32006324b4, content=<a href='/topic/show?id=64782e31314' target=_blank style='color:#2F92EE;'>#信号轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27313, encryptionId=64782e31314, topicName=信号轴)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Jul 14 09:37:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608543, encodeId=c10e1608543ac, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Feb 09 10:37:00 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-06-23 zhaozhouchifen

    #RhoA#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2081890, encodeId=7e4e208189010, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Wed Oct 03 17:37:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987700, encodeId=3835198e7005a, content=<a href='/topic/show?id=a3d81544104' target=_blank style='color:#2F92EE;'>#RhoA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15441, encryptionId=a3d81544104, topicName=RhoA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jun 23 05:37:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068244, encodeId=fdae20682445b, content=<a href='/topic/show?id=e94b298327' target=_blank style='color:#2F92EE;'>#ATS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2983, encryptionId=e94b298327, topicName=ATS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Sun Apr 22 22:37:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006324, encodeId=f7d32006324b4, content=<a href='/topic/show?id=64782e31314' target=_blank style='color:#2F92EE;'>#信号轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27313, encryptionId=64782e31314, topicName=信号轴)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Jul 14 09:37:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608543, encodeId=c10e1608543ac, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Feb 09 10:37:00 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-04-22 12499e01m47暂无昵称

    #ATS#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2081890, encodeId=7e4e208189010, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Wed Oct 03 17:37:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987700, encodeId=3835198e7005a, content=<a href='/topic/show?id=a3d81544104' target=_blank style='color:#2F92EE;'>#RhoA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15441, encryptionId=a3d81544104, topicName=RhoA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jun 23 05:37:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068244, encodeId=fdae20682445b, content=<a href='/topic/show?id=e94b298327' target=_blank style='color:#2F92EE;'>#ATS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2983, encryptionId=e94b298327, topicName=ATS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Sun Apr 22 22:37:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006324, encodeId=f7d32006324b4, content=<a href='/topic/show?id=64782e31314' target=_blank style='color:#2F92EE;'>#信号轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27313, encryptionId=64782e31314, topicName=信号轴)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Jul 14 09:37:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608543, encodeId=c10e1608543ac, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Feb 09 10:37:00 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-07-14 ms920641618706883

    #信号轴#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2081890, encodeId=7e4e208189010, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Wed Oct 03 17:37:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987700, encodeId=3835198e7005a, content=<a href='/topic/show?id=a3d81544104' target=_blank style='color:#2F92EE;'>#RhoA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15441, encryptionId=a3d81544104, topicName=RhoA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jun 23 05:37:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068244, encodeId=fdae20682445b, content=<a href='/topic/show?id=e94b298327' target=_blank style='color:#2F92EE;'>#ATS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2983, encryptionId=e94b298327, topicName=ATS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Sun Apr 22 22:37:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006324, encodeId=f7d32006324b4, content=<a href='/topic/show?id=64782e31314' target=_blank style='color:#2F92EE;'>#信号轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27313, encryptionId=64782e31314, topicName=信号轴)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Jul 14 09:37:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608543, encodeId=c10e1608543ac, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Feb 09 10:37:00 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-09 ms3994565386320060

    #Med#

    0