Nature Biomedical Engineering:“发光”的纳米颗粒“追踪”癌转移

2017-12-14 佚名 生物探索

现有的影像学技术难以检测到微小的癌病变,也无法察觉到早期的癌转移。为了突破难关,来自于罗格斯大学的科学家们研发出一种新型纳米颗粒,可以实时追踪肿瘤发生和转移。

现有的影像学技术难以检测到微小的癌病变,也无法察觉到早期的癌转移。为了突破难关,来自于罗格斯大学的科学家们研发出一种新型纳米颗粒,可以实时追踪肿瘤发生和转移。

“借助发光的纳米颗粒,检测微小的肿瘤并追踪它们的扩散情况。”——12月12日,《Nature Biomedical Engineering》期刊于在线发表一篇文章揭示了这一最新研究成果,有望助力早期癌症检测和更精准的抗癌治疗,从而改善患者的生存时间和质量。

“我们一直希望,可以实时追踪癌症的发展。”文章作者、罗格斯大学生物医学工程教授Prabhas V. Moghe表示,“现在,我们有机会实现疾病的早期诊断。”

“追踪”癌症微转移

癌症手术治疗的致命弱点是微转移(micro metastases),即常规病理学方法不能检测到的癌症转移,通常指单个或者微小的肿瘤细胞团,多隐匿在原发灶以外的位置。而且,大多数影像学方法无法检测到微小的病变。

Prabhas V. Moghe团队希望改变现状,他们开发出能够发出短波红外线的纳米探针,通过静脉注射进入体内,用于检测小鼠体内残留的微小肿瘤。这些微型探针可以伴随血液在体内循环,因而可以在多个器官中追踪肿瘤转移。

比MRI更快更好

纳米探针检测小鼠肾上腺和骨骼中肿瘤微转移的速度明显快于传统的核磁共振成像(MRI)以及其他的癌症监测技术。

文章作者、生物医学工程系的助理教授Vidya Ganapathy认为,这一新技术可以提前数月检测到癌症的存在和转移。“癌细胞能够在身体内不同的缝隙中生长,而探针会‘追踪’这些细胞,无论它们转移到何处。”她强调道。

检测超100种癌症

据悉,新型的纳米探针技术可以检测100多种癌症,包括对多个器官的病灶进行实时检测,能够更精准的实现预防和预后,例如明确癌症的发展阶段。

研究团队预估它有望在5年内应用于临床。未来,纳米探针可以广泛应用于所有外科手术中,负责标记手术计划摘除的组织。此外,还可以追踪免疫疗法的有效性,包括刺激免疫细胞对抗癌细胞。

原始出处:
Harini Kantamneni,et al.Surveillance nanotechnology for multi-organ cancer metastases.Nature Biomedical Engineering 1, 993–1003 (2017)

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    2018-03-25 spoonycyy
  4. [GetPortalCommentsPageByObjectIdResponse(id=1882704, encodeId=5c811882e041f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Mar 11 16:18:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785349, encodeId=15a01e853497d, content=<a href='/topic/show?id=0a9c6e87ef' target=_blank style='color:#2F92EE;'>#Engin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6787, encryptionId=0a9c6e87ef, topicName=Engin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Fri Feb 09 22:18:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081426, encodeId=7278208142698, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sun Mar 25 08:18:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785407, encodeId=c5b61e854076e, content=<a href='/topic/show?id=db0e6e8835' target=_blank style='color:#2F92EE;'>#engineering#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6788, 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channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sat Nov 03 17:18:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323378, encodeId=ce4d13233e89a, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sat Dec 16 01:18:00 CST 2017, 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  5. [GetPortalCommentsPageByObjectIdResponse(id=1882704, encodeId=5c811882e041f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Mar 11 16:18:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785349, encodeId=15a01e853497d, content=<a href='/topic/show?id=0a9c6e87ef' target=_blank style='color:#2F92EE;'>#Engin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6787, encryptionId=0a9c6e87ef, topicName=Engin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Fri Feb 09 22:18:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081426, encodeId=7278208142698, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sun Mar 25 08:18:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785407, encodeId=c5b61e854076e, content=<a href='/topic/show?id=db0e6e8835' target=_blank style='color:#2F92EE;'>#engineering#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6788, 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channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sat Nov 03 17:18:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323378, encodeId=ce4d13233e89a, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sat Dec 16 01:18:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533565, encodeId=461a15335653e, content=<a href='/topic/show?id=7583114e529' target=_blank style='color:#2F92EE;'>#Medical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11475, encryptionId=7583114e529, topicName=Medical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe912466517, createdName=海豹, createdTime=Sat Dec 16 01:18:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590308, encodeId=228d1590308ff, content=<a href='/topic/show?id=2c17e154824' target=_blank style='color:#2F92EE;'>#癌转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71548, encryptionId=2c17e154824, topicName=癌转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dc017794099, createdName=linagood, createdTime=Sat Dec 16 01:18:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608347, encodeId=eb5d160834e9e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Dec 16 01:18:00 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2018-02-22 sunylz
  6. [GetPortalCommentsPageByObjectIdResponse(id=1882704, encodeId=5c811882e041f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Mar 11 16:18:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785349, encodeId=15a01e853497d, content=<a href='/topic/show?id=0a9c6e87ef' target=_blank style='color:#2F92EE;'>#Engin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6787, encryptionId=0a9c6e87ef, topicName=Engin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, 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channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sat Nov 03 17:18:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323378, encodeId=ce4d13233e89a, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sat Dec 16 01:18:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533565, encodeId=461a15335653e, content=<a href='/topic/show?id=7583114e529' target=_blank style='color:#2F92EE;'>#Medical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11475, encryptionId=7583114e529, topicName=Medical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe912466517, createdName=海豹, createdTime=Sat Dec 16 01:18:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590308, encodeId=228d1590308ff, content=<a href='/topic/show?id=2c17e154824' target=_blank style='color:#2F92EE;'>#癌转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71548, encryptionId=2c17e154824, topicName=癌转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dc017794099, createdName=linagood, createdTime=Sat Dec 16 01:18:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608347, encodeId=eb5d160834e9e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Dec 16 01:18:00 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2018-11-03 jeanqiuqiu
  7. 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  8. 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    2017-12-16 海豹
  9. 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包括化疗在内的癌症治疗已经帮助许多患有这种疾病的人过着健康的生活。然而,化疗对身体造成伤害。在治疗期间,化学疗法攻击身体的所有细胞,而不仅仅是癌细胞。结果破坏健康细胞,导致许多患者在治疗期间和治疗后都会发生重大副作用。

Nat Nanotechnol:华人科学家郭培宣教授发明新型RNA纳米技术来“装饰”外泌体可有效抑制肿瘤生长

一项新的研究表明,将抗体样(即Y形状)RNA纳米颗粒附着到微泡上可以将有效的RNA治疗剂如小分子干扰RNA(siRNA)特异性地递送给癌细胞。研究人员利用RNA纳米技术来应用RNA纳米颗粒并控制它们的去向,以产生能够在动物模型中成功靶向三种类型癌症的载有治疗剂的细胞外囊泡。该研究结果发表在最新的Nature Nanotechnology杂志上,可促进使用siRNA、microRNA和其他RNA干扰

Sci Transl Med:纳米颗粒灌注技术帮助解决器官移植问题

研究人员将纳米颗粒技术和体外灌流 (ex vivo perfusion) 技术结合在一起,能够在体外通过对移植器官进行灌流,将携带治疗器官缺陷药物的纳米颗粒运送到到EC附近。

Adv Sci:新型siRNA纳米颗粒有效地逆转了肝损伤

RNA干扰(RNAi)作为后基因组时代的一种下调基因表达的工具已被广泛用于基因功能的研究以及疾病的治疗。近年来随着RNA干扰技术在生命领域的应用以及研究的深入,RNA干扰成为了生命科学领域的一个研究热点。小干扰RNA (siRNA)介导的RNA干扰正是通过下调致病基因从而对很多人类疾病实现治疗,如癌症、自身免疫性疾病以及病毒感染性疾病等。但由于siRNA自身的局限性(细胞内不稳定性、肾清除率高、细

Int J Oncol:金-大黄酚纳米颗粒可通过失活AKT并诱导细胞凋亡和ROS产生抑制前列腺癌的进展

缓释仍是载药释药的最方便的方法。在本研究中,我们制备了大黄酚金纳米颗粒。将金-大黄酚转化为聚(DL-丙交酯-共-乙交酯)纳米颗粒,测试大黄酚纳米颗粒在人LNCap前列腺癌细胞上的生物活性,及缓释性能。圆二色光谱显示,大黄酚纳米颗粒有效地导致DNA构象改变,并调节与细胞周期停滞相关的不同蛋白质。分析活性氧(ROS)、细胞凋亡、细胞周期、DNA损伤、Cyto-c和caspase-3的活性,并使用免疫印