Ann Oncol:锻炼能降低前列腺癌风险?

2018-06-07 吴星 环球医学

2018年5月,发表在《Ann Oncol》的一项由德国科学家进行的系统评价和Meta分析,考察了前列腺癌(PCa)风险相关的身体活动(PA)。

2018年5月,发表在《Ann Oncol》的一项由德国科学家进行的系统评价和Meta分析,考察了前列腺癌(PCa)风险相关的身体活动(PA)。

背景:PCa是男性最常见的癌症之一,然而对其可变风险和预防因素了解较少。本研究旨在量化总结PCa发病率和死亡率与PA相关的观察研究。

材料和方法:使用Medline和EMBASE数据库,检索与PA和PCa发病率和死亡率相关的已发表文章,检索时间到2017年7月。文献评价产生48个队列研究和24个病例对照研究,共151748个PCa病例。基线时,研究参与者的平均年龄为61岁。

结果:在随机效应模型中,最高vs最低总PA水平比较显示,总PCa发病的总相对风险(RR)估算接近于零[RR=0.99,95%置信区间(CI)=0.94~1.04]。晚期和非晚期PCa的RRs分别为0.92(95% CI=0.80~1.06)和0.95(95% CI=0.85~1.07)。研究者注意到,长期职业活动和总PCa之间存在显着的负相关性(RR=0.83,95% CI=0.71~0.98,13项研究),尽管在分析中排除个体研究后结果变得在统计学上不显着。通过癌症亚型进行评价时,观察到非晚期/非侵袭性PCa与长期职业活动之间的负相关性(RR=0.51,95% CI=0.37~0.71,2项研究),定期休闲活动与晚期/侵袭性PCa负相关(RR=0.75,95% CI=0.60~0.95,2项),尽管这些观察结果基于较少数量的研究。此外,PCa幸存者中,诊断后PA与PCa死亡风险减低相关(基于4项研究的总RR=0.69,95% CI=0.55~0.85)。

结论:PA是否能预防PCa仍不清楚。未来的研究需要考虑PCa复杂的临床和病理性质,以明确PA与PCa发病率的相关性。此外,需要未来研究来证实诊断后PA是否会降低PCa的死亡风险。

原始出处: 

Benke IN, Leitzmann MF, Behrens G, et al. Physical activity in relation to risk of prostate cancer: a systematic review and meta-analysis. Ann Oncol. 2018 May 1;29(5):1154-1179.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2061752, encodeId=47f12061e525e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Jul 13 05:51:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022565, encodeId=f5ac202256562, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Mon Dec 17 00:51:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865456, encodeId=2630186545621, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed Nov 07 03:51:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322448, encodeId=d09332244885, content=了解下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jun 08 08:27:27 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050293, encodeId=8238105029358, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Thu Jun 07 13:51:00 CST 2018, time=2018-06-07, status=1, ipAttribution=)]
    2018-07-13 sjq027
  2. [GetPortalCommentsPageByObjectIdResponse(id=2061752, encodeId=47f12061e525e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Jul 13 05:51:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022565, encodeId=f5ac202256562, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Mon Dec 17 00:51:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865456, encodeId=2630186545621, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed Nov 07 03:51:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322448, encodeId=d09332244885, content=了解下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jun 08 08:27:27 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050293, encodeId=8238105029358, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Thu Jun 07 13:51:00 CST 2018, time=2018-06-07, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2061752, encodeId=47f12061e525e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Jul 13 05:51:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022565, encodeId=f5ac202256562, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Mon Dec 17 00:51:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865456, encodeId=2630186545621, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed Nov 07 03:51:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322448, encodeId=d09332244885, content=了解下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jun 08 08:27:27 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050293, encodeId=8238105029358, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Thu Jun 07 13:51:00 CST 2018, time=2018-06-07, status=1, ipAttribution=)]
    2018-11-07 minlingfeng
  4. [GetPortalCommentsPageByObjectIdResponse(id=2061752, encodeId=47f12061e525e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Jul 13 05:51:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022565, encodeId=f5ac202256562, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Mon Dec 17 00:51:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865456, encodeId=2630186545621, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed Nov 07 03:51:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322448, encodeId=d09332244885, content=了解下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jun 08 08:27:27 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050293, encodeId=8238105029358, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Thu Jun 07 13:51:00 CST 2018, time=2018-06-07, status=1, ipAttribution=)]
    2018-06-08 kafei

    了解下谢谢

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2061752, encodeId=47f12061e525e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Jul 13 05:51:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022565, encodeId=f5ac202256562, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Mon Dec 17 00:51:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865456, encodeId=2630186545621, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed Nov 07 03:51:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322448, encodeId=d09332244885, content=了解下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jun 08 08:27:27 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050293, encodeId=8238105029358, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Thu Jun 07 13:51:00 CST 2018, time=2018-06-07, status=1, ipAttribution=)]
    2018-06-07 jingjing

    运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少

    0

相关资讯

Nat Genet:同期2篇论文全面解读前列腺癌的致病基因和突变

全球范围内,前列腺癌发病率逐年升高。在美国,前列腺癌发病率位于男性肿瘤第一位, 死亡率位于第二。据美国癌症协会估计, 2018 年美国会有 16.55万例新发前列腺癌, 并会有 2.94万人死于前列腺癌。在中国,根据我国癌症协会2015年估计,前列腺癌发病率排名第六,死亡率位于第十。前列腺癌已成为严重威胁全球中老年男性健康的疾病。

Oncogene:在前列腺癌中,COX-2能够调控PKCε的促肿瘤作用

促肿瘤激酶PKCε在人类前列腺癌中是过表达的,并且在前列腺癌的发展过程中与肿瘤抑制因子Pten功能丧失协作。然而,促使PKCε调控表型的效应因子到目前为止仍旧不清楚。最近,有研究人员利用细胞学和小鼠模型,展示了PKCε的过表达与Pten功能丧失协同起作用,共同促进NF-κB激活和诱导环氧合酶-2(COX-2)的表达以及表型特性,这些表型特性在人类前列腺肿瘤中同样能够观察到。在前列腺癌细胞中靶向干扰

Sci Rep:经历机器协助的腹腔镜根治性前列腺切除术患者的快速康复外科和传统外科的比较

快速康复外科(FTS)包括了一系基于证据的调整,并且预期可以减少并发症,减轻外科手术应激反应,加速恢复和缩短住院时间,并且还可以提高安全性。最近,有研究人员在经历机器协助的腹腔镜根治性前列腺切除术(RALP)的中国前列腺癌(PCa)患者中严格的评估了FTS的安全性和效果。研究是一个回顾性的分析,包括了73名连续性的中国PCa患者,且他们经历了RALP。研究人员将其分成2个小组:传统外科(CS)和F

Sci Rep:在晚期前列腺癌中,microRNAs可作为潜在的治疗方法来增强化学敏感性

多烯紫杉醇和卡巴他赛是转移性去势难治性前列腺癌(CRPC)治疗的紫衫烷化学疗法。然而,治疗抵抗性仍旧是一个主要问题。MicroRNAs是短的非编码RNAs,并且能够沉默多个基因,可以同时调控一些信号通路。因此,通过合成microRNAs来调控参与紫杉烷响应的基因,在CRPC中也许具有治疗的潜力,并且还可以最小化引起紫杉烷抗性的代偿机制。最近,有研究人员为了鉴定哪些microRNAs能够改善紫杉烷在

Prostate Cancer P D:在PTEN缺失前列腺癌转基因小鼠模型中,血清胆固醇水平和肿瘤生长研究

一些但不是全部的流行病学证据支持了胆固醇在前列腺癌中为类固醇激素合成的前体。最近,有研究人员利用一个PTEN缺失前列腺癌转基因小鼠模型,测试了改变过的血清胆固醇水平对前列腺肿瘤发育和生长的影响情况。研究人员假设血清胆固醇的减少会降低肿瘤雄激素水平和减缓前列腺癌生长。研究人员发现,依泽替米贝处理的小鼠在第4个月具有更低的血清胆固醇水平(p=0.031)。血清胆固醇与前列腺重量(p=0.033)和肿瘤

CLIN CANCER RES:分子淋巴结状态有助于对前列腺癌患者进行预后分层

使用qPCR对淋巴结进行分子分析检测淋巴结转移的敏感度高于病理学检查。但是,接受根治性前列腺切除联合扩大盆腔淋巴结清扫的前列腺癌患者分子淋巴结状态的预后效果并不明确。CLIN CANCER RES近期发表了一篇文章,研究分子淋巴结状态与生化复发之间的关系。