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Neurology:补充维生素B可降脑血管病患者卒中事件

2013-09-23 晓静 编译 医学论坛网

脑血管疾病患者维生素B卒中事件
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中国郑州大学第一附属医院的学者对脑血管疾病患者补充维生素B以降低同型半胱氨酸水平的疗效进行了荟萃分析。结果表明，通过补充维生素B来减少同型半胱氨酸可显著减少患者卒中事件，尤其是接受适当干预措施具有某些特征的受试者。研究论文9月18日在线发表于《神经病学》（Neurology）杂志。【原文阅读】 研究者纳入了于2012年8月之前发表的评估卒中事件的临床试验，利用混合效应模型和χ2试验的95

中国郑州大学第一附属医院的学者对脑血管疾病患者补充维生素B以降低同型半胱氨酸水平的疗效进行了荟萃分析。结果表明，通过补充维生素B来减少同型半胱氨酸可显著减少患者卒中事件，尤其是接受适当干预措施具有某些特征的受试者。研究论文9月18日在线发表于《神经病学》（Neurology）杂志。【原文阅读】

研究者纳入了于2012年8月之前发表的评估卒中事件的临床试验，利用混合效应模型和χ2试验的95%置信区间（95% CIs）相对危险度（RR）评估补充维生素B与终点事件的相关性。研究共纳入14项随机对照试验的54913例受试者。

结果显示，补充维生素B之后患者的同型半胱氨酸水平有所减少，进而引起总体卒中事件减少（RR 0.93，95% CI 0.86–1.00，P = 0.04）。但在根据主要或次要预防措施、缺血性和出血性卒中或致命性卒中发生分配的亚组中未见到类似结果。≥3年随访期间的亚组和无谷物叶酸强化的背景下或慢性肾脏疾病（CKD）中，也有卒中事件减少的有益效应。

一些纳入CKD患者的试验显示，补充维生素B的患者肾小球滤过率降低。关于维生素B12剂量或基线血B12浓度方面，详细的维生素B12亚组分析并未显示出明显获益。血压和基线受试者药物应用的分层分析显示，收缩压>130 mm Hg和减少卒中风险的抗血小板药物较少的患者可获益。　

原文阅读

Ji Y, Tan S, Xu Y, Chandra A, Shi C, Song B, Qin J, Gao Y.Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: A meta-analysis.Neurology. 2013 Sep 18.                 

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    2013-11-23 yinhl1978

    #Neurol#

    0

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    2014-01-14 Luyuxie_17

    #血管病#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1999340, encodeId=38bc1999340d9, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Nov 23 00:39:00 CST 2013, time=2013-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1644386, encodeId=0260164438686, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Tue Jan 14 15:39:00 CST 2014, time=2014-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508494, encodeId=21d9150849477, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Wed Sep 25 02:39:00 CST 2013, time=2013-09-25, status=1, ipAttribution=)]
    2013-09-25 马龙

    #维生素B#

    0