Atherosclerosis:与CAC患者1年内全因死亡率相关预测因子

2015-08-26 徐媛媛 MedSci原创

冠状动脉钙化(CAC)反映了冠状动脉斑块负荷和独立预测因素的全因死亡率。高负荷亚临床动脉粥样硬化的预后存在明显异质性,然而,决定亚临床不良结局的直接因素目前尚不知晓。研究人员共纳入4234名患者且CAC≥400。本研究采用多变量Cox比例危险模型分析并评估了传统心血管风险因素与1年内死亡率之间的相关性。患者平均年龄在64±10岁,其中男性占56%,CAC评分中位数为809(IQR 761)。在多变

冠状动脉钙化(CAC)反映了冠状动脉斑块负荷和独立预测因素的全因死亡率。高负荷亚临床动脉粥样硬化的预后存在明显异质性,然而,决定亚临床不良结局的直接因素目前尚不知晓。

研究人员共纳入4234名患者且CAC≥400。本研究采用多变量Cox比例危险模型分析并评估了传统心血管风险因素与1年内死亡率之间的相关性。

患者平均年龄在64±10岁,其中男性占56%,CAC评分中位数为809(IQR 761)。在多变量模型中,糖尿病、吸烟、年龄、CAC和血脂异常与1年全因死亡率相关,HR分别为2.62(1.55-4.43)、2.42(1.41-4.15)、1.52(1.16-1.99)、1.33(CAC 1.11-1.56)和0.58(0.34-0.98)。与高血压无显著相关性[HR (95% CI) = 0.90 (0.55-1.47)].

吸烟和糖尿病与CAC患者1年内全因死亡率密切相关,这或许也表明糖尿病、吸烟、年龄、CAC和血脂异常等因素是急性事件的诱因。

原始出处

Al Rifai M1, McEvoy JW1, Nasir K2, Rumberger J3, Feldman D1, Budoff MJ4, Blaha MJ1.Traditional cardiovascular disease risk factors associated with one-year all-cause mortality among those with coronary artery calcium scores ≥400.Atherosclerosis. 2015 Aug

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    2015-08-28 lsndxfj
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