J Gastroen Hepatol:结直肠癌发病率与年龄——50岁以下人群vs50-54岁人群

2017-10-21 zhangfan MedSci原创

研究认为50岁以下人群结肠镜确诊的结直肠肿瘤发病率显著低于50-54岁人群,但45-49岁人群仍属于结肠癌风险人群

对于50岁以下的中青年人群,筛查诊断性结肠镜检测确诊的结直肠晚期肿瘤发生率尚不清楚。近日研究人员比较了50岁以下人群与50-54岁人群的结直肠肿瘤风险差异。

这些多中心、回顾研究在14个医疗中心开展。研究人员比较50岁以下与50-54岁人群筛查和诊断性结肠镜检查中肿瘤和晚期肿瘤的检出率差异。

研究招募了9765名参与者,50岁以下人群相对于50-54岁人群其肿瘤检出率显著降低(5.9% vs 9.3%, P < 0.001)。相对于50-54岁人群,45-49岁人群,40-44岁人群以及20-39岁人群的肿瘤筛查阳性风险分别减少23%, 53%和54% 。晚期肿瘤在年轻人群的检出率为5%,显著低于50-54岁人群的11.8%(P < 0.001)。相对于50-54岁人群,45-49岁人群,40-44岁人群以及20-39岁人群的晚期肿瘤风险分别减少50%, 66%,和71%。

研究认为50岁以下人群结肠镜确诊的结直肠肿瘤发病率显著低于50-54岁人群,但45-49岁人群仍属于结肠癌风险人群。

原始出处:


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    2018-01-16 许安
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  5. 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  6. 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encodeId=4a412550e496, content=为什么没有对比55以上人群呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sun Oct 22 10:20:24 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254910, encodeId=86e525491042, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Oct 21 19:17:32 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254883, encodeId=5677254883cc, content=谢谢分享.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Oct 21 13:53:07 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-23 gwc384
  7. 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GetPortalCommentsPageByObjectIdResponse(id=254883, encodeId=5677254883cc, content=谢谢分享.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Oct 21 13:53:07 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
  8. 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GetPortalCommentsPageByObjectIdResponse(id=254883, encodeId=5677254883cc, content=谢谢分享.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Oct 21 13:53:07 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-22 Jianghuiqin

    为什么没有对比55以上人群呢?

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=254883, encodeId=5677254883cc, content=谢谢分享.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Oct 21 13:53:07 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-21 131****1460

    学习了受益匪浅

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=254883, encodeId=5677254883cc, content=谢谢分享.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Oct 21 13:53:07 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-21 清风拂面

    谢谢分享.学习受益匪浅

    0

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2017 CSCO:蔡三军教授:非手术治疗可能是针对进展期直肠癌更有价值的治疗

2017年9月26日-30日,备受业内瞩目的“第20届全国临床肿瘤大会暨2017年CSCO学术年会”在厦门隆重开幕。本届年会以“传承创新,携手同行”为主题,并继续秉承CSCO的根本宗旨,开展了多种形式的继续教育和学术交流活动。在此次大会上,来自复旦大学附属肿瘤医院大肠外科的中国临床肿瘤协作中心(CSCO)常委、继续教育委员会主任——蔡三军教授围绕“局部晚期直肠癌wait and see 治疗策略进

GUT:口腔微生物竟然可以预测结肠直肠癌!

微生物群落的变化与结肠直肠癌(CRC)密切相关,特别是在结肠肿瘤患者中,可能具有较高的口腔细菌丰富度。然而,目前尚不知道结肠粘膜相关的分类群是否确实是口腔中衍生的,这种情况是否是患者的独特情况,亦或者口腔微生物群体适合用于筛选CRC患者。近期,一项发表在杂志GUT的研究从CRC患者(99名受试者),结肠直肠息肉患者(32名)或对照组(103名)的个体中分析口腔拭子、结肠粘膜和粪便中的微生物群情况。

Mol Carcinogen: 钙摄入量对结直肠癌风险的影响

钙在细胞信号、增殖和死亡中起着关键作用。以前的研究探讨膳食钙摄入量与结直肠癌之间的关系有矛盾的结果,可能是由于没有考虑肾脏钙的再吸收变化。Qi Dai博士及其同事研究了参与田纳西结肠直肠息肉研究的患者参与钙重吸收与结肠直肠腺瘤(癌前病变)的风险相关的基因变化。他们发现,钙离子交换蛋白与钙的摄入在结直肠腺瘤风险中相互作用。他们进一步发现,钙摄入量超过1000毫克/天的三个钙重吸收基因中的两个变异携带

NCCN临床实践指南:遗传/家族高风险评估-结直肠癌(2017.V3)

2017年10月,美国国家综合癌症网络(NCCN)发布了结直肠癌遗传/家族高风险评估指南2017年第3版,指南主要内容涉及: 指南更新摘要 高风险结直肠癌综合征 非息肉病综合征 息肉病综合征

JCEM:雌激素影响结直肠癌进展的机制或与G蛋白偶联受体的增殖有关

背景:尽管目前缺乏精确的分子机制,但雌激素能影响结直肠癌的发生和发展。目的:本研究旨在探讨雌激素代谢的前受体——人类CRC组织、TCGA Coad数据集、体内外的CRC模型研究中的类固醇硫酸酯酶(STS)和17β-羟类固醇脱氢酶的活性,及随后的非基因组雌激素信号,以及确定和哪种雌激素能改变CRC增殖和进展和其治疗的靶向通路。设计、设置、患者和干预:研究人员从绝经后妇女和根据年龄匹配的男性患者中,收

JAMA Oncology:DNA错配修复(MMR)状态能否预测III期结肠癌患者的预后?

在结直肠癌患者的免疫治疗中,DNA错配修复(MMR)缺陷和高的微卫星不稳定(MSI-H)是重要的生物标志物。在此之前,已经有很多关于MMR状态与结直肠癌患者预后关系的研究。近期发表在《JAMA Oncology》的一项大样本量的汇总分析,在接受了FOLFOX方案辅助化疗的III期结肠癌患者中,评估MMR状态与患者术后无病生存期的关系。