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J Biomed Mater Res B Appl Biomater：硅掺杂磷酸钙骨移植材料可快速诱导临界尺寸骨缺损的骨再生

2018-06-24 MedSci MedSci原创

关注

与当前用于牙槽嵴增强的临床可用的骨移植材料相比，对于具有较高再吸收性的生物活性骨替代物的需求很大，这同时可增强骨生成。这促使硅掺杂的可快速吸收的正磷酸钙钙（Si-CAOP）和硅掺杂的β-磷酸三钙（Si-TCP）的研发。这项研究评估了这两种微粒移植材料与目前临床使用的β-TCP相比对植入后2周，以及1、3、6、12和18个月的骨形成和成骨标志物表达的影响。在树脂包埋切片上进行I型胶原，碱性磷酸酶和骨

与当前用于牙槽嵴增强的临床可用的骨移植材料相比，对于具有较高再吸收性的生物活性骨替代物的需求很大，这同时可增强骨生成。这促使硅掺杂的可快速吸收的正磷酸钙钙（Si-CAOP）和硅掺杂的β-磷酸三钙（Si-TCP）的研发。

这项研究评估了这两种微粒移植材料与目前临床使用的β-TCP相比对植入后2周，以及1、3、6、12和18个月的骨形成和成骨标志物表达的影响。在树脂包埋切片上进行I型胶原，碱性磷酸酶和骨钙蛋白表达的免疫组织化学分析。通过组织形态学测定骨、颗粒面积分数和骨-生物材料接触。

结果显示，2周和1个月后，与Si-TCP和TCP相比，Si-CAOP移植的骨缺损处显示出明显更大的骨面积分数、骨-颗粒接触、成骨标记物表达，和明显更低的颗粒面积分数。到第3和第6个月，所有研究的材料都能在12个月和18个月时发挥出色骨再生作用，进一步进行骨重塑。

综合起来，该研究表明，Si-CAOP可以最迅速的诱导临界尺寸骨缺损的骨再生。

原始出好：

Knabe C1, Adel-Khattab D, et al., Effect of silicon-doped calcium phosphate bone grafting materials on bone regeneration and osteogenic marker expression after implantation in the ovine scapula. J Biomed Mater Res B Appl Biomater. 2018 May 16. doi: 10.1002/jbm.b.34153.


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    2018-10-03 sunylz

    #Bio#

    0

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    2019-06-08 howi

    #骨移植#

    0

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    2018-06-26 lfcmxl

    #骨缺损#

    0

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    2018-06-26 zhaojie88

    #骨再生#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1918154, encodeId=d703191815474, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Oct 03 09:46:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667144, encodeId=54d4166e1447f, content=<a href='/topic/show?id=3dae101809cd' target=_blank style='color:#2F92EE;'>#骨移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101809, encryptionId=3dae101809cd, topicName=骨移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbed26112986, createdName=howi, createdTime=Sat Jun 08 00:46:00 CST 2019, time=2019-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419264, encodeId=c4b3141926491, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Tue Jun 26 11:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472135, encodeId=dbd114e213517, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jun 26 11:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608898, encodeId=662a1608898f1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jun 26 11:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326870, encodeId=49753268e0b6, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Mon Jun 25 09:42:31 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326695, encodeId=69723266955f, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Jun 24 21:04:00 CST 2018, time=2018-06-24, status=1, ipAttribution=)]
    2018-06-26 ms3994565386320060

    #Med#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1918154, encodeId=d703191815474, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Oct 03 09:46:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667144, encodeId=54d4166e1447f, content=<a href='/topic/show?id=3dae101809cd' target=_blank style='color:#2F92EE;'>#骨移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101809, encryptionId=3dae101809cd, topicName=骨移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbed26112986, createdName=howi, createdTime=Sat Jun 08 00:46:00 CST 2019, time=2019-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419264, encodeId=c4b3141926491, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Tue Jun 26 11:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472135, encodeId=dbd114e213517, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jun 26 11:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608898, encodeId=662a1608898f1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jun 26 11:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326870, encodeId=49753268e0b6, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Mon Jun 25 09:42:31 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326695, encodeId=69723266955f, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Jun 24 21:04:00 CST 2018, time=2018-06-24, status=1, ipAttribution=)]
    2018-06-25 139****5926

    好好文章学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1918154, encodeId=d703191815474, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Oct 03 09:46:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667144, encodeId=54d4166e1447f, content=<a href='/topic/show?id=3dae101809cd' target=_blank style='color:#2F92EE;'>#骨移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101809, encryptionId=3dae101809cd, topicName=骨移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbed26112986, createdName=howi, createdTime=Sat Jun 08 00:46:00 CST 2019, time=2019-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419264, encodeId=c4b3141926491, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Tue Jun 26 11:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472135, encodeId=dbd114e213517, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jun 26 11:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608898, encodeId=662a1608898f1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jun 26 11:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326870, encodeId=49753268e0b6, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Mon Jun 25 09:42:31 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326695, encodeId=69723266955f, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Jun 24 21:04:00 CST 2018, time=2018-06-24, status=1, ipAttribution=)]
    2018-06-24 天地飞扬

    了解一下.谢谢分享!

    0