Anesthesiology:明确心脏手术中与卒中相关的术中低血压阈值

2019-09-29 anesthGH “罂粟花”微信号

卒中是接受心脏手术的患者发病率、死亡率和残疾的主要原因。明确可避免的围手术期卒中危险因素可能会改善患者的预后。本文评估了心脏手术患者术中低血压的严重程度和持续时间与术后卒中之间的关系。

背景与目的

卒中是接受心脏手术的患者发病率、死亡率和残疾的主要原因。明确可避免的围手术期卒中危险因素可能会改善患者的预后。本文评估了心脏手术患者术中低血压的严重程度和持续时间与术后卒中之间的关系。

方  法

本项回顾性队列研究对于2009年11月1日至2015年3月31日期间在三级医院进行体外循环心脏手术的成年患者进行了回顾性研究。主要结局为术后缺血性卒中。术中低血压定义为在体外循环之前、期间和之后平均动脉压小于55、55至64和65至74 mmHg数分钟。通过使用逻辑回归来分析卒中和低血压之间的关联。

结  果

本研究纳入了7457例患者,其中111(1.5%)例患者术后诊断为卒中。卒中与体外循环期间持续平均动脉压低于64 mmHg密切相关(校正OR值为1.13; 95%CI,每10分钟平均动脉压在55至64 mmHg的比值为1.05-1.21;校正OR值为 1.16; 95%CI,每10分钟平均动脉压小于55 mmHg 的比值为1.08至1.23)。与卒中独立相关的其他因素包括年龄较大,高血压,联合冠状动脉旁路移植/瓣膜手术,急诊手术,延长的心肺分流持续时间和术后新发心房颤动。

结  论

低血压是围手术期卒中的潜在的可避免的危险因素。该研究的结果表明,平均动脉压可能是一项对术中血流动力学重要的治疗性靶点,可降低接受体外循环患者的卒中发生率。

原始出处:

Sun L Y , Chung A M , Farkouh M E , et al. Defining an Intraoperative Hypotension Threshold in Association with Stroke in Cardiac Surgery[J]. Anesthesiology, 2018:1-.

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    2019-10-01 qjddjq
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    2019-10-01 skhzy
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    2019-09-29 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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