J Allergy Clin Immun:维生素D与哮喘

2017-05-27 Darren 来宝网

在《过敏和临床免疫学杂志》上发表的一项新研究发现,在怀孕期间服用维生素D补充剂可以积极地改变新生儿的免疫系统,这可以有助于新生儿防止哮喘和呼吸道感染。英国伦敦国王学院的研究人员研究了在怀孕的第二和第三个月每天补充4,400 IU维生素D3对新生儿的影响情况。



【孕妇补充维生素D如何影响胎儿免疫系统】在《过敏和临床免疫学杂志》上发表的一项新研究发现,在怀孕期间服用维生素D补充剂可以积极地改变新生儿的免疫系统,这可以有助于新生儿防止哮喘和呼吸道感染。英国伦敦国王学院的研究人员研究了在怀孕的第二和第三个月每天补充4,400 IU维生素D3对新生儿的影响情况。

参加者孕期均为10至18周,随机分为高剂量或低剂量的维生素D补充剂组。然后研究人员收集 51名孕妇的脐带血,测试新生儿先天免疫系统的反应性。先天免疫系统的反应性是指其身体对感染的第一道防线,针对感染身体提供持久保护的T淋巴细胞的反应。

研究者们发现,补充较高水平维生素D3的母亲,其婴儿的血液样本可以通过产生更多的先天细胞因子和IL-17A来刺激T淋巴细胞,这两种类型的反应可以改善新生儿感染时受损的免疫系统防御。鉴于婴儿早期生活中强烈的免疫反应与哮喘发展相关,所以研究团队认为,这种作用可能改善儿童呼吸系统的健康状况。

伦敦国王学院首席研究员Catherine Hawrylowicz教授说:“大多数哮喘病例在患者处于儿童时期就被诊断,这意味着该病的起源于胎儿的早期生命。迄今为止有研究调查过维生素D与婴幼儿免疫力之间的关系。我们的研究第一次表明,怀孕期间较高水平的维生素D可能能够有效改变新生儿的免疫系统反应,有助于降低儿童哮喘的发生概率。”

英国哮喘研究和政策主任Samantha Walker博士说:“维生素D是哮喘研究中很有前途的领域,但这项研究只是揭示二者关系的初步研究。虽然研究结果表明,对于孕妇而言,维生素D补充剂可能会改善胎儿免疫反应,但需要更多的研究来证明这是否能够影响胎儿日后哮喘的发生情况。

原始出处:

Eve Hornsby, Paul E. Pfeffer, Nancy Laranjo, et al. Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial. Journal of Allergy and Clinical Immunology (2017). DOI: dx.doi.org/10.1016/j.jaci.2017.02.039.

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    2017-05-30 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2017-05-29 膀胱癌
  3. [GetPortalCommentsPageByObjectIdResponse(id=204246, encodeId=e82d2042465f, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue May 30 06:51:45 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328946, encodeId=98c1132894655, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon May 29 13:08:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203875, encodeId=243a2038e57d, content=学习研究了,, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 29 07:30:48 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203671, encodeId=e8ea2036e1e1, content=为了孩子的健康,还是补一些吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun May 28 18:29:57 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203573, encodeId=5fc22035e3b4, content=好的,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun May 28 12:06:35 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203340, encodeId=e689203340db, content=“维生素D是哮喘研究中很有前途的领域,但这项研究只是揭示二者关系的初步研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat May 27 23:15:21 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-29 惠映实验室

    学习研究了,

    0

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    2017-05-28 Y—xianghai

    为了孩子的健康,还是补一些吧!

    0

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    2017-05-28 Drhzm308

    好的,学习了

    0

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    2017-05-27 有备才能无患

    “维生素D是哮喘研究中很有前途的领域,但这项研究只是揭示二者关系的初步研究。

    0

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