JAHA:年轻妇女的急性冠状动脉综合征风险如何?

2017-12-22 xing.T MedSci原创

由此可见,年轻人发生的ACS特点是冠状动脉狭窄程度高,ST段抬高心肌梗死患病率较高。女性的死亡率高于男性。年轻是男性30天死亡率较低的独立预测因子,但在女性中不存在。

虽然急性冠脉综合征(ACS)主要发生于超过50岁的患者中,但年轻患者也会受到影响。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员将45岁作为年龄分界点,旨在分析年轻ACS患者的临床特征和预后。

在2010年10月至2016年4月之间,研究人员从ISACS-TC(转型国家的急性冠状动脉综合征国际调查)登记中心招募了14931例ACS患者。这些患者中,1182(8%)名患者小于45岁(平均年龄为40.3岁;15.8%为女性)。该研究的主要终点为30天全因死亡率。直径狭窄程度小于50%定义为不显著的冠状动脉疾病。

研究人员发现ST段抬高性心肌梗死是年轻ACS患者最为常见的临床表现(68% vs. 59.6%)。年轻患者的冠状动脉疾病发生率较高(11.4% vs. 10.1%),冠状动脉狭窄程度高(单血管,62.7% vs. 46.6%)。年轻和老年患者30天死亡的发生率分别为1.3%和6.9%。将基线和临床差异校正后,年龄小于45岁是男性生存的预测因素(比值比为0.24;95%可信区间为0.10-0.58),但在女性中不是(比值比为1.35;95%可信区间为0.50-3.62)。在将住院治疗和再灌注治疗进行多变量校正后,这种性别逆转的风险模式仍然存在。此外,年轻女性的预后比同年龄的男性更差(比值比为6.03,95%可信区间为2.07-17.53)。

由此可见,年轻人发生的ACS特点是冠状动脉狭窄程度高,ST段抬高心肌梗死患病率较高。女性的死亡率高于男性。年轻是男性30天死亡率较低的独立预测因子,但在女性中不存在。

原始出处:


Beatrice Ricci,et al. Acute Coronary Syndrome: The Risk to Young Women.JAHA.2017. https://doi.org/10.1161/JAHA.117.007519

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    2017-12-24 zhaohui6731
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    2017-12-23 chunjianf

    学习了.谢谢分享

    0

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    2017-12-23 changjiu

    学习一下谢谢

    0

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    2017-12-22 有备才能无患

    虽然急性冠脉综合征(ACS)主要发生于超过50岁的患者中.但年轻患者也会受到影响.近日.心血管疾病领域权威杂志JAHA上发表了一篇研究文章.研究人员将45岁作为年龄分界点.旨在分析年轻ACS患者的临床特征和预后

    0

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    2017-12-22 1e1b8538m79(暂无匿称)

    不错的文章.值得拥有

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1706834, encodeId=14cb1e0683410, content=<a href='/topic/show?id=15bd30902cc' target=_blank style='color:#2F92EE;'>#冠状动脉综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30902, encryptionId=15bd30902cc, topicName=冠状动脉综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=345831322662, createdName=124985dbm16(暂无昵称), createdTime=Wed Jun 20 14:26:00 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267661, encodeId=91ac126e66129, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Dec 24 11:26:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431049, encodeId=57841431049dc, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Sun Dec 24 11:26:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271708, encodeId=13672e1708e3, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Sat Dec 23 06:36:14 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271699, encodeId=ecf12e1699b0, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Dec 23 05:36:35 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271656, encodeId=a19c2e165647, content=虽然急性冠脉综合征(ACS)主要发生于超过50岁的患者中.但年轻患者也会受到影响.近日.心血管疾病领域权威杂志JAHA上发表了一篇研究文章.研究人员将45岁作为年龄分界点.旨在分析年轻ACS患者的临床特征和预后, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Dec 22 23:48:21 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271646, encodeId=d2ff2e1646de, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Dec 22 22:49:59 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271642, encodeId=751b2e164234, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Fri Dec 22 22:48:24 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271617, encodeId=90f22e1617fc, content=年轻女性患ACS恶性风险更高., beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Dec 22 21:09:48 CST 2017, time=2017-12-22, status=1, ipAttribution=)]
    2017-12-22 131****2916

    不错的文章值得推荐

    0

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    2017-12-22 1e0f8808m18(暂无匿称)

    年轻女性患ACS恶性风险更高.

    0

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