BMC Infectious Diseases: 白细胞介素-6比降钙素原和C反应蛋白更能预测抗生素治疗效果

2019-02-24 不详 MedSci原创

本研究的目的是评估与降钙素原(PCT)和C-反应蛋白(CRP)相比,白细胞介素-6(IL-6)是否能成为严重脓毒症和脓毒性休克成人治疗成功的敏感指标。

背景
本研究的目的是评估与降钙素原(PCT)和C-反应蛋白(CRP)相比,白细胞介素-6(IL-6)是否能成为严重脓毒症和脓毒性休克成人治疗成功的敏感指标。

方法
研究人员回顾性分析2009年9月至2012年1月在莱比锡大学医院的医疗重症监护室(ICU)管理的严重脓毒症和感染性休克的成年患者的数据。所有患者都有入院时以及24和48-72小时后的CRP,PCT和IL-6的值。如果患者在ICU住院期间存活,抗生素治疗被定义为临床成功。

结果
本项研究共纳入328例严重脓毒症和感染性休克的患者。48-72小时后,幸存者的中位IL-6显着低于非幸存者(114.2 pg / ml vs 746.6 pg / ml; p <0.001),而PCT和CRP没有显着差异(5.6 vs. 4.9ng / ml; p = 0.586);(158.5mg / l对172.4mg / l; p = 0.988)。

结论
该研究的结果表明IL-6在预测最初48-72小时内脓毒症的治疗成功率方面优于PCT和CRP。

原始出处:

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  5. 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    2019-02-26 Tamikia
  8. 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    2019-02-26 dongjia2015
  9. 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    2019-02-24 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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