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Langmuir:氧化石墨烯和溶菌酶超薄膜功能化植体表面具有强大的应用前景

2019-05-14 不详 网络

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全世界对骨相关植入材料的需求很大。慢性感染和当前植入材料的骨愈合不良的缺点限制了其临床应用。在植入材料上使用抗菌和成骨膜功能化植入物表面为制造新型植入物材料提供了新的机会。在本研究中，研究人员使用逐层（LBL）技术以及氧化石墨烯（GO）和溶菌酶（Lys）的替代沉积来制造几十纳米的超薄（GO/Lys）8膜。椭圆光度法，紫外-可见光和傅立叶变换红外结果显示，（GO / Lys）n薄膜的沉积呈现连续生长

全世界对骨相关植入材料的需求很大。慢性感染和当前植入材料的骨愈合不良的缺点限制了其临床应用。在植入材料上使用抗菌和成骨膜功能化植入物表面为制造新型植入物材料提供了新的机会。

在本研究中，研究人员使用逐层（LBL）技术以及氧化石墨烯（GO）和溶菌酶（Lys）的替代沉积来制造几十纳米的超薄（GO/Lys）8膜。椭圆光度法，紫外-可见光和傅立叶变换红外结果显示，（GO / Lys）n薄膜的沉积呈现连续生长，并使用原子力显微镜表征该薄膜的物理性质（形态，粗糙度和刚度）。超薄膜对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌的细菌灭菌效果明显，提高了成骨分化效率，在骨移植涂层中具有潜在的应用价值。

综上所述，我们相信这种LBL组装策略将为制造双功能表面铺平道路，并指导未来植入表面的设计。

原始出处：

Li M, Li H, et al., Graphene Oxide and Lysozyme Ultrathin Films with Strong Antibacterial and Enhanced Osteogenesis. Langmuir. 2019 May 9. doi: 10.1021/acs.langmuir.9b00035.

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#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1651596, encodeId=27a1165159651, content=<a href='/topic/show?id=6e78e32573c' target=_blank style='color:#2F92EE;'>#石墨烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73257, encryptionId=6e78e32573c, topicName=石墨烯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db924213398, createdName=yangjxjc, createdTime=Fri Sep 27 23:12:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706997, encodeId=10b61e06997ae, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Wed Jul 17 15:12:00 CST 2019, time=2019-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943065, encodeId=4345194306544, content=<a href='/topic/show?id=f5bd4931673' target=_blank style='color:#2F92EE;'>#应用前景#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49316, encryptionId=f5bd4931673, topicName=应用前景)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af60254, createdName=mhm289, createdTime=Mon Jan 06 18:12:00 CST 2020, time=2020-01-06, status=1, ipAttribution=)]
    2019-09-27 yangjxjc

    #石墨烯#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1651596, encodeId=27a1165159651, content=<a href='/topic/show?id=6e78e32573c' target=_blank style='color:#2F92EE;'>#石墨烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73257, encryptionId=6e78e32573c, topicName=石墨烯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db924213398, createdName=yangjxjc, createdTime=Fri Sep 27 23:12:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706997, encodeId=10b61e06997ae, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Wed Jul 17 15:12:00 CST 2019, time=2019-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943065, encodeId=4345194306544, content=<a href='/topic/show?id=f5bd4931673' target=_blank style='color:#2F92EE;'>#应用前景#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49316, encryptionId=f5bd4931673, topicName=应用前景)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af60254, createdName=mhm289, createdTime=Mon Jan 06 18:12:00 CST 2020, time=2020-01-06, status=1, ipAttribution=)]
    2019-07-17 ms7899726347904398

    #化石#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1651596, encodeId=27a1165159651, content=<a href='/topic/show?id=6e78e32573c' target=_blank style='color:#2F92EE;'>#石墨烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73257, encryptionId=6e78e32573c, topicName=石墨烯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db924213398, createdName=yangjxjc, createdTime=Fri Sep 27 23:12:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706997, encodeId=10b61e06997ae, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Wed Jul 17 15:12:00 CST 2019, time=2019-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943065, encodeId=4345194306544, content=<a href='/topic/show?id=f5bd4931673' target=_blank style='color:#2F92EE;'>#应用前景#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49316, encryptionId=f5bd4931673, topicName=应用前景)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af60254, createdName=mhm289, createdTime=Mon Jan 06 18:12:00 CST 2020, time=2020-01-06, status=1, ipAttribution=)]
    2020-01-06 mhm289

    #应用前景#

    0