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Mater Sci Eng C Mater Biol Appl：超声波氧化石墨烯增强骨骼和皮肤伤口再生

2018-11-21 MedSci MedSci原创

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在本研究中，我们研究了超声波氧化石墨烯（UGO）在骨再生和皮肤伤口愈合中的应用。 GO悬浮液的超声处理增加了GO悬浮液的分散和稳定性（通过增加ζ电位）。UGO具有较少的含氧基团，但仍显示出优异的水分散性。UGO悬浮液对人胎儿成骨细胞（hFOB细胞）、人内皮细胞（EA.hy 926细胞）和小鼠胚胎成纤维细胞显示出高生物相容性。重要的是，UGO除了促进种子细胞的成骨和促进新骨形成外，还可促进细

在本研究中，我们研究了超声波氧化石墨烯（UGO）在骨再生和皮肤伤口愈合中的应用。

GO悬浮液的超声处理增加了GO悬浮液的分散和稳定性（通过增加ζ电位）。UGO具有较少的含氧基团，但仍显示出优异的水分散性。UGO悬浮液对人胎儿成骨细胞（hFOB细胞）、人内皮细胞（EA.hy 926细胞）和小鼠胚胎成纤维细胞显示出高生物相容性。重要的是，UGO除了促进种子细胞的成骨和促进新骨形成外，还可促进细胞的粘附和增殖。此外，1％UGO悬浮液在体外皮肤划痕试验中增强细胞迁移，并促进体内大鼠切除皮肤缺损模型中的伤口闭合。

综上所述，这些结果表明，UGO为参与骨和皮肤愈合的细胞提供了良好的环境，这表明其在组织再生中的潜在应用。

原始出处：

Hussein KH, Abdelhamid HN, et al., Ultrasonicated graphene oxide enhances bone and skin wound regeneration. Mater Sci Eng C Mater Biol Appl. 2019 Jan 1;94:484-492. doi: 10.1016/j.msec.2018.09.051. Epub 2018 Sep 25.

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    2019-05-01 spoonycyy

    #Eng#

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    2019-06-11 ms7899726347904398

    #化石#

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    2019-06-12 yangjxjc

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    2019-08-13 yyj074

    #超声波#

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    2019-10-11 12498ebem31暂无昵称

    #Biol#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2081508, encodeId=9fa1208150884, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed May 01 01:08:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706986, encodeId=b7d21e0698652, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Tue Jun 11 09:08:00 CST 2019, time=2019-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651579, encodeId=769816515e96f, content=<a href='/topic/show?id=6e78e32573c' target=_blank style='color:#2F92EE;'>#石墨烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73257, encryptionId=6e78e32573c, topicName=石墨烯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db924213398, createdName=yangjxjc, createdTime=Wed Jun 12 16:08:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745069, encodeId=96321e45069c2, content=<a href='/topic/show?id=b1519280810' target=_blank style='color:#2F92EE;'>#超声波#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92808, encryptionId=b1519280810, topicName=超声波)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea5135506123, createdName=yyj074, createdTime=Tue Aug 13 03:08:00 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767565, encodeId=0bd11e6756575, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri Oct 11 23:08:00 CST 2019, time=2019-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918410, encodeId=f8bf191841031, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jun 20 23:08:00 CST 2019, time=2019-06-20, status=1, ipAttribution=)]
    2019-06-20 sunylz

    #Bio#

    0