Plos One:获得性免疫治疗对肝细胞癌患者是否有益?

2017-03-27 MedSci MedSci原创

获得性免疫治疗(AIT)对接受治愈性治疗的肝细胞癌(HCC)患者的作用尚未得到充分说明。近期,一项发表在Plos One上的荟萃分析旨在更新目前有关接受治愈疗法的HCC患者的AIT疗效和安全性的相关证据。此项研究于2017年1月搜索PubMed、EMBASE、Scopus和Cochrane图书馆数据库。在有或无辅助AIT的患者之间比较死亡率和肿瘤复发情况。荟萃分析使用Review Manager

获得性免疫治疗(AIT)对接受治愈性治疗的肝细胞癌(HCC)患者的作用尚未得到充分说明。


近期,一项发表在Plos One上的荟萃分析旨在更新目前有关接受治愈疗法的HCC患者的AIT疗效和安全性的相关证据。

此项研究于2017年1月搜索PubMed、EMBASE、Scopus和Cochrane图书馆数据库。在有或无辅助AIT的患者之间比较死亡率和肿瘤复发情况。荟萃分析使用Review Manager 5.3进行。

此项研究结果显示:共有8项涉及1861例患者的研究符合入选标准。使用AIT与1年(RR 0.64,95%CI 0.52-0.79),3年(RR 0.73,95%CI 0.65-0.81)和5年(RR 0.86,95%CI 0.79-0.94)的死亡率显着降低。此外,与单独予以治愈性疗法相比,使用AIT的1年(RR 0.64,95%CI 0.49-0.82),3年(RR 0.85,95%CI 0.79-0.91)和5年(RR 0.90,95%CI 0.85-0.95)复发率明显降低。所有患者均未发生4级不良事件。

此项研究结果表明:接受治愈性疗法后的HCC患者辅助性予以AIT可以降低死亡风险和肿瘤复发。

原始出处:
Mo HY, Liao YY, et al. Timely meta-analysis on the efficacy of adoptive immunotherapy for hepatocellular carcinoma patients after curative therapy. PLoS One. 2017 Mar 24;12(3):e0174222. doi: 10.1371/journal.pone.0174222. eCollection 2017.

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    2017-08-08 xjy02
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2042583, encodeId=1c5a20425834b, content=<a href='/topic/show?id=999c88014ea' target=_blank style='color:#2F92EE;'>#获得性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88014, encryptionId=999c88014ea, topicName=获得性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Wed May 10 23:55:00 CST 2017, time=2017-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863264, encodeId=f6b71863264c5, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Aug 08 04:55:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978482, encodeId=a44619e848214, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Feb 28 04:55:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789909, encodeId=1aee1e89909fa, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu May 18 07:55:00 CST 2017, time=2017-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183213, encodeId=fa1a1832132d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Tue Mar 28 07:57:58 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183201, encodeId=afe21832018f, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Mar 28 07:48:07 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183103, encodeId=f1c318310316, content=加油学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGYaG3DtvrLVJ7HhIECWX4ll1PfCD3ibABpkrZH09K1t3LBib16Twic4GC4YC5eeQ29w9rDgacd9FSH/0, createdBy=f3ae2037787, createdName=医之美, createdTime=Mon Mar 27 20:57:07 CST 2017, time=2017-03-27, status=1, ipAttribution=)]
    2017-03-28 tofsw

    学习了谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2042583, encodeId=1c5a20425834b, content=<a href='/topic/show?id=999c88014ea' target=_blank style='color:#2F92EE;'>#获得性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88014, encryptionId=999c88014ea, topicName=获得性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Wed May 10 23:55:00 CST 2017, time=2017-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863264, encodeId=f6b71863264c5, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Aug 08 04:55:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978482, encodeId=a44619e848214, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Feb 28 04:55:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789909, encodeId=1aee1e89909fa, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu May 18 07:55:00 CST 2017, time=2017-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183213, encodeId=fa1a1832132d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Tue Mar 28 07:57:58 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183201, encodeId=afe21832018f, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Mar 28 07:48:07 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183103, encodeId=f1c318310316, content=加油学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGYaG3DtvrLVJ7HhIECWX4ll1PfCD3ibABpkrZH09K1t3LBib16Twic4GC4YC5eeQ29w9rDgacd9FSH/0, createdBy=f3ae2037787, createdName=医之美, createdTime=Mon Mar 27 20:57:07 CST 2017, time=2017-03-27, status=1, ipAttribution=)]
    2017-03-28 ylzr123

    好文,值得点赞,更值得收藏!慢慢领会学习的。

    0

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    2017-03-27 医之美

    加油学习

    0