ACS Nano:眼泪和汗水不白流 可用于监测葡萄糖水平

2018-01-27 石岩 环球医学

糖尿病患者需要实时监测自己的血糖水平以避免可能的并发症,然而很多患者对于每天刺破手指的血糖监测方式在心理和身体上都很排斥,因此改善这些患者的监测体验成为众多科学家为之努力的方向。近日,《ACS Nano》杂志上报道了一种超薄、柔韧的传感器,使无创、便捷的葡萄糖监测成为可能。

糖尿病患者需要实时监测自己的血糖水平以避免可能的并发症,然而很多患者对于每天刺破手指的血糖监测方式在心理和身体上都很排斥,因此改善这些患者的监测体验成为众多科学家为之努力的方向。近日,《ACS Nano》杂志上报道了一种超薄、柔韧的传感器,使无创、便捷的葡萄糖监测成为可能。

伴随着数字化世界的蓬勃发展,可穿戴式传感器应运而生。但是目前商业上可用的传感器通常通过测量所采取的步骤(例如心率)来监测身体活动。尽管在分子水平上创建测量健康指标的方法更具挑战性,但其也具有改变生活的潜力,这使得征服挑战变得更有意义。

诊断和跟踪通常需要通过分析某人的血液样本来完成。然而,指尖取血或抽血的痛苦使需要定期检查的糖尿病患者对监测产生排斥情绪。为了改善这一情况,科学家正努力研制可穿戴的葡萄糖传感器,但过程中受到多种因素的阻碍。有些设备无法检测出汗液和眼泪中的低水平葡萄糖,或在被弯曲时停止工作。

基于纳米带和纳米线的场效应晶体管(FET)生物传感器是解决这些问题的一匹“黑马”,但大多数FET生物传感器通过使用体积庞大的Ag/AgCl电极或金属线闸门而工作,这阻止了生物传感器的实用性。而Moh Amer、Chongwu Zhou及其同事们开发的新型生物传感器可以放置到隐形眼镜或腕表的背面,向糖尿病患者提供一种改进的监测工具,通过眼泪或汗水可实时追踪一个人体内的葡萄糖水平。

研究人员利用氧化铟纳米带、酶葡萄糖氧化酶、天然壳聚糖膜和单壁碳纳米管创建了一个生物传感器。当测试样本中存在葡萄糖时,它与酶相互作用,引发短链反应并最终产生电信号。测试表明,该设备检测的浓度范围很广,跨越至少5个数量级,可以检测10纳摩尔到1毫摩尔范围内的葡萄糖浓度。其灵敏度足以检测糖尿病患者的汗液、唾液和眼泪中的葡萄糖水平。不仅如此,该装置即便被弯曲100次也不会影响其表现。除了葡萄糖跟踪,研究人员还建议将传感器用于食品和环境部门的监测。

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    2018-01-29 Ramsey

    学习一下.虽然感觉有点扯

    0

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    2018-01-29 yaanren
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    2018-01-29 xiay994457
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    2018-01-27 龙胆草

    学习谢谢分享

    0

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    2018-01-27 明月清辉

    谢谢分享.学习了

    0

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    2018-01-27 清风拂面

    很好的文章.谢谢分享

    0

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