BMJ:贝伐珠单抗和雷珠单抗治疗糖尿病黄斑水肿无显著性差异

2012-08-15 张一宸 医学论坛网

    8月13日《英国医学杂志》(BMJ)在线发表的一项系统回顾和间接比较研究结果发现,贝伐珠单抗和雷珠单抗治疗糖尿病黄斑水肿的作用并无显著性差异,但仍需要进一步头对头的研究来证实。   数据来源于Medline (1996–2011年9月),Embase (1996–2011年9月)及临床对照试验中心注册数据库(Issue&nbsp

    8月13日《英国医学杂志》(BMJ)在线发表的一项系统回顾和间接比较研究结果发现,贝伐珠单抗和雷珠单抗治疗糖尿病黄斑水肿的作用并无显著性差异,但仍需要进一步头对头的研究来证实。

  数据来源于Medline (1996–2011年9月),Embase (1996–2011年9月)及临床对照试验中心注册数据库(Issue 4, 2011)。研究入选标准为研究方法相似的雷珠单抗或贝伐珠单抗治疗糖尿病黄斑水肿研究。

  主要结果为最佳矫正视力提高超过ETDRS量表2行(糖尿病视网膜病变早期治疗研究)的患者比率。次要结果是最佳视力平均变化、黄斑中心凹厚度以及不良事件。用logMAR(最小分辨角对数)表示最佳矫正视力,数值增加代表视力降低。采用贝叶斯方法评估雷珠单抗和贝伐单抗的治疗效果。

  该项间接比较共纳入5个符合要求的研究。分析结果显示,贝伐珠单抗最佳视力提高2行的比例为21/77(27%),雷珠单抗为60/152(39%)。贝伐珠单抗平均矫正视力变化(logMAR-0.08)优于雷珠单抗,但无显著差异,二者黄斑中心凹厚度改变无显著差异。

  英文链接:

Ford JA, Elders A, Shyangdan D, Royle P, Waugh N.The relative clinical effectiveness of ranibizumab and bevacizumab in diabetic macular oedema: an indirect comparison in a systematic review.BMJ. 2012 Aug 13;345:e5182. doi: 10.1136/bmj.e5182.


    

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    2013-06-30 gaoxiaoe
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topicName=水肿)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476924, encodeId=b3f114e6924ba, content=<a href='/topic/show?id=c32e9220221' target=_blank style='color:#2F92EE;'>#贝伐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92202, encryptionId=c32e9220221, topicName=贝伐)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef557344179, createdName=sunrural_42825359, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507043, encodeId=4f12150e04358, content=<a href='/topic/show?id=b0da98838c7' target=_blank style='color:#2F92EE;'>#雷珠单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98838, encryptionId=b0da98838c7, topicName=雷珠单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=01ea9855129, createdName=shanyongle, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510888, encodeId=efcb1510888fa, content=<a href='/topic/show?id=abd8103141b8' target=_blank style='color:#2F92EE;'>#黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103141, encryptionId=abd8103141b8, topicName=黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9a10269982, createdName=xiay994456, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518200, encodeId=c8a7151820073, content=<a href='/topic/show?id=371de681325' target=_blank style='color:#2F92EE;'>#糖尿病黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76813, encryptionId=371de681325, topicName=糖尿病黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b88311125888, createdName=循证小兵, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525045, encodeId=e3de1525045d9, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=)]
    2012-08-17 小华子
  5. [GetPortalCommentsPageByObjectIdResponse(id=1819004, encodeId=71311819004df, content=<a href='/topic/show?id=b3f69883997' target=_blank style='color:#2F92EE;'>#雷珠单抗治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98839, encryptionId=b3f69883997, topicName=雷珠单抗治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jan 16 23:01:00 CST 2013, time=2013-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1954788, encodeId=323d1954e8819, content=<a href='/topic/show?id=e4f39220658' target=_blank style='color:#2F92EE;'>#贝伐珠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92206, encryptionId=e4f39220658, topicName=贝伐珠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Mon May 20 23:01:00 CST 2013, time=2013-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847470, encodeId=fcde184e470bd, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Jun 30 20:01:00 CST 2013, time=2013-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333309, encodeId=7e37133330966, content=<a href='/topic/show?id=4ce26423802' target=_blank style='color:#2F92EE;'>#水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64238, encryptionId=4ce26423802, topicName=水肿)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476924, encodeId=b3f114e6924ba, content=<a href='/topic/show?id=c32e9220221' target=_blank style='color:#2F92EE;'>#贝伐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92202, encryptionId=c32e9220221, topicName=贝伐)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef557344179, createdName=sunrural_42825359, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507043, encodeId=4f12150e04358, content=<a href='/topic/show?id=b0da98838c7' target=_blank style='color:#2F92EE;'>#雷珠单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98838, encryptionId=b0da98838c7, topicName=雷珠单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=01ea9855129, createdName=shanyongle, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510888, encodeId=efcb1510888fa, content=<a href='/topic/show?id=abd8103141b8' target=_blank style='color:#2F92EE;'>#黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103141, encryptionId=abd8103141b8, topicName=黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9a10269982, createdName=xiay994456, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518200, encodeId=c8a7151820073, content=<a href='/topic/show?id=371de681325' target=_blank style='color:#2F92EE;'>#糖尿病黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76813, encryptionId=371de681325, topicName=糖尿病黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b88311125888, createdName=循证小兵, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525045, encodeId=e3de1525045d9, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1819004, encodeId=71311819004df, content=<a href='/topic/show?id=b3f69883997' target=_blank style='color:#2F92EE;'>#雷珠单抗治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98839, encryptionId=b3f69883997, topicName=雷珠单抗治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jan 16 23:01:00 CST 2013, time=2013-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1954788, encodeId=323d1954e8819, content=<a href='/topic/show?id=e4f39220658' target=_blank style='color:#2F92EE;'>#贝伐珠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92206, encryptionId=e4f39220658, topicName=贝伐珠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, 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topicName=水肿)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476924, encodeId=b3f114e6924ba, content=<a href='/topic/show?id=c32e9220221' target=_blank style='color:#2F92EE;'>#贝伐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92202, encryptionId=c32e9220221, topicName=贝伐)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef557344179, createdName=sunrural_42825359, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507043, encodeId=4f12150e04358, content=<a href='/topic/show?id=b0da98838c7' target=_blank style='color:#2F92EE;'>#雷珠单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98838, encryptionId=b0da98838c7, topicName=雷珠单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=01ea9855129, createdName=shanyongle, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510888, encodeId=efcb1510888fa, content=<a href='/topic/show?id=abd8103141b8' target=_blank style='color:#2F92EE;'>#黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103141, encryptionId=abd8103141b8, topicName=黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9a10269982, createdName=xiay994456, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518200, encodeId=c8a7151820073, content=<a href='/topic/show?id=371de681325' target=_blank style='color:#2F92EE;'>#糖尿病黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76813, encryptionId=371de681325, topicName=糖尿病黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b88311125888, createdName=循证小兵, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525045, encodeId=e3de1525045d9, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=)]
  7. 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time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518200, encodeId=c8a7151820073, content=<a href='/topic/show?id=371de681325' target=_blank style='color:#2F92EE;'>#糖尿病黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76813, encryptionId=371de681325, topicName=糖尿病黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b88311125888, createdName=循证小兵, createdTime=Fri Aug 17 06:01:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525045, encodeId=e3de1525045d9, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, 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  8. 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    2012-08-17 muzishouyi

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