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DIABETOLOGIA：髋关节和膝关节骨关节炎对随后发生糖尿病风险的影响

2018-12-23 MedSci MedSci原创

髋关节和膝关节骨关节炎事件糖尿病
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本研究探讨了髋/膝关节骨性关节炎与糖尿病发病之间的关系。首先，研究人员假设髋/膝关节骨关节炎与发生糖尿病的风险增加独立相关，并且这种关系至少部分是由于行走困难所致。此外，还假设与膝关节发生糖尿病的关系比，髋关节骨关节炎更强，因为前者肥胖/代谢综合征患病率较高。 研究人员对从1996年至1998年招募的年龄≥55岁的人口队列通过省级卫生行政数据一直随访到2014年。将基线调查时的糖尿病患者排除

本研究探讨了髋/膝关节骨性关节炎与糖尿病发病之间的关系。首先，研究人员假设髋/膝关节骨关节炎与发生糖尿病的风险增加独立相关，并且这种关系至少部分是由于行走困难所致。此外，还假设与膝关节发生糖尿病的关系比，髋关节骨关节炎更强，因为前者肥胖/代谢综合征患病率较高。

研究人员对从1996年至1998年招募的年龄≥55岁的人口队列通过省级卫生行政数据一直随访到2014年。将基线调查时的糖尿病患者排除。将髋/膝关节骨性关节炎定义为在过去3个月中任何关节中的肿胀，疼痛或僵硬持续6周，以及关节髋关节/膝关节出现“不适”。将行走受限定义为在过去3个月中自行报告的站立或行走困难（是/否）。使用Cox回归分析，调查基线髋/膝关节骨关节炎与糖尿病的关系，这些关系来自健康管理数据，限定年龄，性别，BMI，收入，既往高血压，心血管疾病和初级保健暴露。研究人员调查了他们所观察到的效应是否是由行走限制所引起的。

本研究共纳入16,362名参与者，中位年龄68岁，女性61％。其中，1637（10％）人满足髋关节骨关节炎的标准，2431（15％）为膝关节骨关节炎，3908（24％）被认定为行走受限。中位随访13.5年（四分位数范围7.3-17.8），3539人（22％）患有糖尿病。

研究认为，在一个年龄≥55岁，基线时没有糖尿病且控制混杂因素的大量人群研究中，髋/膝关节骨关节炎的存在和负担是糖尿病发病的重要独立预测因素。行走受限一定程度解释了这种关联。对骨关节炎和骨关节炎相关功能受限的关注有可能降低糖尿病风险。

原始出处：

Tetyana Kendzerska, Lauren K. King, Lorraine Lipscombe, The impact of hip and knee osteoarthritis on the subsequent risk of incident diabetes: a population-based cohort study

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    2019-10-29 ms5439512287675881

    #BET#

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    2019-02-11 ms9608593228839890

    #DIA#

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    2019-07-18 lisa438

    #骨关节#

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    2018-12-25 lmm397

    #关节炎#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1760941, encodeId=28061e6094154, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Oct 29 00:53:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638910, encodeId=98a6163891093, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Feb 11 01:53:00 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026608, encodeId=fd8d202660852, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Thu Jul 18 23:53:00 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265872, encodeId=513112658e290, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Dec 25 02:53:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579403, encodeId=992e15e940368, content=<a href='/topic/show?id=78ec85884e7' target=_blank style='color:#2F92EE;'>#膝关节骨关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85884, encryptionId=78ec85884e7, topicName=膝关节骨关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e7b16514606, createdName=ms306040998833292, createdTime=Tue Dec 25 02:53:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042133, encodeId=c81010421339b, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Dec 23 14:53:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356187, encodeId=f6d435618e31, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Dec 23 12:47:14 CST 2018, time=2018-12-23, status=1, ipAttribution=)]
    2018-12-25 ms306040998833292

    #膝关节骨关节炎#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1760941, encodeId=28061e6094154, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Oct 29 00:53:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638910, encodeId=98a6163891093, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Feb 11 01:53:00 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026608, encodeId=fd8d202660852, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Thu Jul 18 23:53:00 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265872, encodeId=513112658e290, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Dec 25 02:53:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579403, encodeId=992e15e940368, content=<a href='/topic/show?id=78ec85884e7' target=_blank style='color:#2F92EE;'>#膝关节骨关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85884, encryptionId=78ec85884e7, topicName=膝关节骨关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e7b16514606, createdName=ms306040998833292, createdTime=Tue Dec 25 02:53:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042133, encodeId=c81010421339b, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Dec 23 14:53:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356187, encodeId=f6d435618e31, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Dec 23 12:47:14 CST 2018, time=2018-12-23, status=1, ipAttribution=)]
    2018-12-23 misszhang

    谢谢MedSci提供最新的资讯

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1760941, encodeId=28061e6094154, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Oct 29 00:53:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638910, encodeId=98a6163891093, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Feb 11 01:53:00 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026608, encodeId=fd8d202660852, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Thu Jul 18 23:53:00 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265872, encodeId=513112658e290, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Dec 25 02:53:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579403, encodeId=992e15e940368, content=<a href='/topic/show?id=78ec85884e7' target=_blank style='color:#2F92EE;'>#膝关节骨关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85884, encryptionId=78ec85884e7, topicName=膝关节骨关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e7b16514606, createdName=ms306040998833292, createdTime=Tue Dec 25 02:53:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042133, encodeId=c81010421339b, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Dec 23 14:53:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356187, encodeId=f6d435618e31, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Dec 23 12:47:14 CST 2018, time=2018-12-23, status=1, ipAttribution=)]
    2018-12-23 医者仁心5538

    学习了

    0