EUR J Cancer:阿司匹林与其他血小板聚集抑制剂对结直肠癌患者生存期的影响

2017-12-28 MedSci MedSci原创

数项研究表明,阿司匹林作为一种血小板聚集抑制剂(TAI),其介导的癌症患者生存期的改善是通过阿司匹林对血小板聚集的抑制实现的。这项研究的目的是通过流行病学证据研究阿司匹林和非阿司匹林TAI治疗结直肠癌患者的有效性差异。

数项研究表明,阿司匹林作为一种血小板聚集抑制剂(TAI),其介导的癌症患者生存期的改善是通过阿司匹林对血小板聚集的抑制实现的。这项研究的目的是通过流行病学证据研究阿司匹林和非阿司匹林TAI治疗结直肠癌患者的有效性差异。

在这个观察性研究中,研究者综合了荷兰癌症组织数据和PHARMO网络数据库的数据,使用阿司匹林的患者、使用阿司匹林与其他非阿司匹林TAI的患者和未使用TAI的患者被筛选出来进行总生存期的研究。总共有9196例患者被确认为结直肠癌,1766例患者在确诊后使用TAI治疗,其中非阿司匹林类TAI主要是氯吡格雷和双嘧达莫。结果显示,阿司匹林的使用显著增加了总生存期,但阿司匹林和非阿司匹林TAI同时使用的患者并没有显示出更好的结果。

综合来看,经确诊后的结直肠癌患者使用阿司匹林能够显著降低死亡率,提高总生存期。但阿司匹林与其他非阿司匹林TAI的联合使用并不会产生叠加效应。 

原始出处:

Frouws, M. A., et al. "The difference in association between aspirin use and other thrombocyte aggregation inhibitors and survival in patients with colorectal cancer." European Journal of Cancer 2017 77: 24-30. doi.org/10.1016/j.ejca.

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    2018-01-03 jklm09
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    2018-01-07 大爰

    学习了谢谢分享!!

    0

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    2017-12-29 大爰

    学习了谢谢分享!!

    0

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